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Phytochemistry, bioactivity: suggestion of Ceratonia siliqua L. as neurodegenerative disease therapy

  • Imane Lakkab EMAIL logo , Hanane El Hajaji , Nadya Lachkar , Brahim El Bali , Mohammed Lachkar and Alin Ciobica
Published/Copyright: May 29, 2018
Journal of Complementary and Integrative Medicine
From the journal Journal of Complementary and Integrative Medicine Volume 15 Issue 4

Abstract

Carob tree (Ceratonia siliqua L.) is one of the most widespread medicinal plants in the Mediterranean area. Traditionally, it was cultivated for its ethnopharmacological benefits and, more especially, for the seeds, which served as unit of measurement of jewelers “carat.” Hence, in the last half-century, numerous studies reported a wide range of phytoconstituents contained in all parts of Ceratonia siliqua such as phenolic compounds, flavonoids, tannins, anthocyanins, alkaloids, glycosides, proteins and minerals. This review article unveils the phytochemical constituents, bioactivity and pharmacological studies of Ceratonia siliqua. Recent studies have shown that the extracts of this plant exhibit an antioxidant, antidiarrheal, antibacterial, antifungal, anti-inflammatory, antidiabetic activities and also hepatoprotective and antiproliferative effects. In this review, we provide a summary of the most interesting data related to bioactivity and therapeutic potential of Ceratonia siliqua in a way to suggest possible future studies that may use Ceratonia siliqua as an undeniable natural alternative for neurodegenerative diseases treatment.

Keywords: Ceratonia siliqua L.; neurodegenerative diseases; oxidative stress; phytochemistry

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2018-01-29
Accepted: 2018-04-14
Published Online: 2018-05-29

© 2018 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jcim-2018-0013
Keywords for this article
Ceratonia siliqua L.; neurodegenerative diseases; oxidative stress; phytochemistry

Articles in the same Issue

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  2. Acute and subacute toxicity of aqueous extract of the tuber of Kedrostis africana (L.) Cogn in Wistar rats
  3. Protective effects of persian honey, Apis Mellifera Meda Skorikov on side effects of chemotherapy and ischemia/reperfusion induced testicular injury
  4. Chemical composition and antioxidant activity of phenolic compounds and essential oils from Calamintha nepeta L.
  5. Analgesic, anti-inflammatory and anti-arthritic properties of aqueous and methanolic stem bark extracts from Nauclea pobeguinii (Rubiacee) in rats
  6. Testicular and spermatotoxic potential of methanol extract of red cultivar Allium cepa in rats
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  8. Premature ovarian failure of autoimmune etiology in 46XX patients: is there a hope?
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