Ethnomedicinal, phytochemical and pharmacological profile of a mangrove plant Ceriops Decandra GriffDin Hou.

References

[1] Tomilson PB. The botany of mangroves. Cambridge: Cambridge University Press; 1986. p. 374–81.Search in Google Scholar

[2] Bandaranayake WM. Traditional and medicinal uses of mangroves. Mang Salt Marsh. 1998;2:133–48.10.1023/A:1009988607044Search in Google Scholar

[3] Watt JM, Breyer-Brandwijk MG. The medicinal and poisonous plants of southern and eastern Africa. 2nd ed. Edinburgh and London: E & S. Livingstone Ltd; 1962.Search in Google Scholar

[4] Duke JA, Wain KK. Medicinal plants of the world, computer index with more than 85,000 entries. vol. 3. U.K: Longman group Ltd; 1981.Search in Google Scholar

[5] Kathiresan K, Ramanathan T. Medicinal plants of Parangipettai Coast, Monograph. Parangipettai, India: Annamalai University; 1997. p. 79.Search in Google Scholar

[6] Wu Jun, Xiao Qiang, Xu Jing, Li Min-Yi, Pan Jian-Yu, Yang Mei-hua. Natural products from true mangrove flora: source, chemistry and bioactivities. Natural Product Reports. 2008;25(5):955. DOI: 10.1039/b807365a.Search in Google Scholar PubMed

[7] Huang Yelin, Tan Fengxiao, Su Guohua, Deng Shulin, He Hanghang, Shi Suhua. Population genetic structure of three tree species in the mangrove genus Ceriops (Rhizophoraceae) from the Indo West Pacific. Genetica. 2007 8 10;133(1):47–56.10.1007/s10709-007-9182-1.Search in Google Scholar PubMed

[8] . The medicinal and poisonous plants of southern and eastern Africa, 2nd ed. Edinburgh and London: E & S. Livingstone Ltd, 1962.Search in Google Scholar

[9] Lin P, Fu Q. Environmental ecology and economic utilization of mangroves in China (in Chinese). Beijing: Higher Education Press; 1995. p. 1–95.Search in Google Scholar

[10] Ko WC. In Flora Reipublicae Popularis Sinicae. Fang W-P, Chang C-Y, Eds. vol. 52. Beijing: Science Press. 2009: 130–2.Search in Google Scholar

[11] Lin P. Marine higher plant ecology. Beijing: Science Press; 2006. p. 76–80.Search in Google Scholar

[12] Rastogi RP, Mehrotra BN. Compendium of Indian medicinal plants. vol. 1. New Delhi: Publications & Information Directorate; 1991.Search in Google Scholar

[13] Mujeeb Farina, Bajpai Preeti, Pathak Neelam. Phytochemical Evaluation, Antimicrobial Activity, and Determination of Bioactive Components from Leaves ofAegle marmelos. BioMed Research International. 2014;2014:1–11.10.1155/2014/497606.Search in Google Scholar PubMed PubMed Central

[14] The botany of mangroves. Cambridge: Cambridge University Press, 1986:374–81.Search in Google Scholar

[15] Duke NC, Meynecke JO, Dittmann S, Ellison AM, Anger K, Berger U, et al. A world without mangroves? Science. 2007;317:41–2.10.1126/science.317.5834.41bSearch in Google Scholar PubMed

[16] Robertson AI, Alongi DM, eds. Tropical mangrove ecosystems. Coastal and Estuarine Studies 41. Washington, DC: American Geophysical Union; 1992:329.10.1029/CE041Search in Google Scholar

[17] Das S, Ghose M. Pollen morphology of some mangrove plants of Sunderbans, West Bengal. J Natl Bot Soc (India). 1990;44:59–75.Search in Google Scholar

[18] Sheue CR, Liu HY, Tsai CC, Rashid SMA, Yong JWH, Yang YP. On the morphology and molecular basis of segregation of Ceriops zippeliana and C. decandra (Rhizophoraceae) from Asia. Blumea. 2009;54:220–7.10.3767/000651909X476193Search in Google Scholar

[19] Bandaranayake WM. Bioactivities, bioactive compounds and chemical constituents of mangrove plants. Wetlands Ecol Manag. 2002;10:421–52.10.1023/A:1021397624349Search in Google Scholar

[20] Bandaranayake WM. Traditional and medicinal uses of mangroves. Mang Salt Marshes. 1998;2:133–48.10.1023/A:1009988607044Search in Google Scholar

[21] Pattanaik C, Reddy CS, Dhal NK, Das R. Utilisation of mangrove forests in Bhitarkanika wildlife sanctuary, Orissa. Indian J Trad Knowl. 2008;7(4):598–603.Search in Google Scholar

[22] Kirtikar KR, Basu BD. Indian medicinal plants. 2nd ed. India: International Book Distributors; 1999. p. 1012.Search in Google Scholar

[23] Raju AJS, Jonathan KH, Rao SP. Traditional extraction of bark tannin from the mangrove tree, ceriops decandra (griff.) Ding Hou and its use in treating cotton fishing nets. Nat Prod Rad. 2008;7:173–5.Search in Google Scholar

[24] Duke JA, Wain KK. Medicinal plants of the world, computer index with more than 85,000 entries, Vol. Three. U.K: Longman group Ltd; 1981.Search in Google Scholar

[25] Magwa ML, Gundidza M, Gweru N, Humphrey G. Chemical composition and biological activities of essential oil from the leaves of Sesuvium portulacastrum. J Ethnopharmacol. 2005;103:85.10.1016/j.jep.2005.07.024Search in Google Scholar PubMed

[26] Uddin SJ, Shilpi JA, Barua J, Rouf R. Antinociceptive activity of Ceriops decandra leaf and pneumatophore. Fitoterapia. 2005;76:261–3.10.1016/j.fitote.2004.12.015Search in Google Scholar

[27] Anjaneyulu ASR, Rao VL, Lobkovsky E, Clardy J. Ceriopsin E, a new epoxy ent-Kaurene Diterpenoid from Ceriops decandra. J Nat Prod. 2002;65:592–4.10.1021/np010540pSearch in Google Scholar

[28] Anjaneyulu ASR, Rao VL. Ceriopsins F and G, diterpenoids from ceriops decandra. Phytochemistry. 2003;62:1207–11.10.1016/S0031-9422(02)00627-1Search in Google Scholar

[29] Anjaneyulu ASR, Rao VL, Ceriopsins A–D. diterpenoids from Ceriops decandra. Phytochemistry. 2002;60:777–82.10.1016/S0031-9422(02)00087-0Search in Google Scholar

[30] Kumar VA, Ammani K, Siddhardha B, Sreedhar U, Kumar GA. Differential biological activities of the solvent extracts of Ceriops decandra (Griff.) and their phytochemical investigations. J Pharm Res. 2013 July;7:654–60.10.1016/j.jopr.2013.05.024Search in Google Scholar

[31] Ponglimanont C, Thongdeeying P. Lupane-triterpene esters from the leaves of Ceriops decandra (Griff.). Ding Hou Aust J Chem. 2005;58:615–8.10.1071/CH05087Search in Google Scholar

[32] Pakhathirathien C, Chantrapromma S, Fun H-K, Anjum S, Atta-ur-Rahman C, Karalaia C. 1-Isoprpenyl-3a,5a,5b,8,8,11a-hexamethylicosahydro-1H-cyclopenta-[a]chrysene-9-yl 4-hydroxy-3-methoxycinnamate. Acta Crystallogr Sect. 2005;61:2942–4.10.1107/S1600536805025584Search in Google Scholar

[33] Seshadri TR, Trikha RK. Procyanidins of Ceriops roxburghiana and Rhizophora conjugata. Ind JChem. 1971;9:928–30.Search in Google Scholar

[34] Ghosh A, Misra S, Dutta AK, Choudhury A. Pentacyclic terpenoids and steroids from seven species of mangrove. Phytochemistry. 1985;24:1725–7.10.1016/S0031-9422(00)82541-8Search in Google Scholar

[35] Wang H, Li MY, Satyanandamurty T, Wu J. New diterpenes from a Godavari mangrove, Ceriops decandra. Planta Med. 2013;79:666–72.10.1055/s-0032-1328459Search in Google Scholar PubMed

[36] Simlai A, Mukherjee K, Mandal A, Bhattacharya K, Samanta A, Roy A. Partial purification and characterization of an antimicrobial activity from the wood extract of mangrove plant Ceriops decandra. EXCLI J. 2016;15:103–12.Search in Google Scholar

[37] Vadlapudi V, Naidu KC. In vitro antimicrobial activity Ceriops decandra against selected aquatic, human and phytopathogens. Int J Chem Tech Res. 2009;1:1236–8.Search in Google Scholar

[38] Chandrasekaran M, Kannathasan K, Venkatesalu V, Prabhakar K. Antibacterial activity of some salt marsh halophytes and mangrove plants against methicillin resistant Staphylococcus aureus. World J Microbiol Biotechnol. 2009;25:155–60.10.1007/s11274-008-9869-1Search in Google Scholar

[39] Ravikumar S, Gnanadesigan M, Suganthi P, Ramalakshmi A. Antibacterial potential of chosen mangrove plants against isolated urinary tract infectious bacterial pathogens. Int J Med Med Sci. 2010;2:94–9.Search in Google Scholar

[40] Simlai A, Roy A. Analysis of and correlation between phytochemical and antimicrobial constituents of Ceriops decandra, a medicinal mangrove plant, from Indian Sundarban estuary. J Med Plants Res. 2012 August 22;6:4755–65.10.5897/JMPR12.657Search in Google Scholar

[41] Nebula M, Harisankar HS, Chandramohanakumar N. Metabolites and bioactivities of Rhizophoraceae mangroves. Nat Prod Bioprospect. 2013;3:207–32.10.1007/s13659-013-0012-0Search in Google Scholar

[42] Wu J, Xiao Q, Xu J, Li MY, Pan JY, Yang MH. Natural products from true mangrove flora: source, chemistry and bioactivities. Nat Prod Rep. 2008;25:955–81.10.1039/b807365aSearch in Google Scholar

[43] Gnanadesigana M, Ravikumar S, Anand M. Hepatoprotective activity of Ceriops decandra (Griff.) Ding Houmangrove plant against CCl₄ induced liver damage. J Taibah Univ Sci. 2017;11:450–7.10.1016/j.jtusci.2016.07.004Search in Google Scholar

[44] Vundru AK, Kandru A, Busi S, Uppalapati S, Gudapati AK. Differential biological activities of the solvent extracts of Ceriops decandra (Griff.) and their phytochemical investigations. J Pharm Res. 2013;7:654–60.10.1016/j.jopr.2013.05.024Search in Google Scholar

[45] Kathiresan K, Veera Ravi A. Seasonal changes in tannin content of mangrove leaves. Ind For. 1990;116:390–2.Search in Google Scholar

[46] Boopathy NS, Kandasamy K, Subramanian M, You-Jin J. Effect of mangrove tea extract from Ceriops decandra (Griff.) Ding Hou. on salivary bacterial flora of DMBA induced Hamster Buccal Pouch Carcinoma. Indian J Microbiol. 2011 Jul;51:338–44. Epub 2011 Feb 27. DOI: 10.1007/s12088-011-0096-3Search in Google Scholar

[47] Padmakumar K (1988). Bioactive substances from marine algae and mangroves. Ph.D Thesis, Annamalai University, Parangipettai p. 81.Search in Google Scholar

[48] Duke JA, Wain KK. Medicinal plants of the world. Essex: Longman Group UK; 1981.Search in Google Scholar

[49] Trapp S, Croteau R. Defensive resian biosynthesis in conifers. Annu Rev Plant Physiol Plant Mol Biol. 2001;52:689–724.10.1146/annurev.arplant.52.1.689Search in Google Scholar

[50] Perry LM. Medicinal plants of East and Southeast Asia. Cambridge: MIT Press; 1980.Search in Google Scholar

[51] Bandaranayake WM. Bioactivities, bioactive compounds and chemical constituents of mangrove plants. Wet. Ecol Manag. 2002;10:421–52.10.1023/A:1021397624349Search in Google Scholar

[52] Wang H, Lia M-Y, Jun W. Chemical constituents and some biological activities of plants from the genus Ceriops – review. Chem Biodivers.2012;9:1–11.10.1002/cbdv.201000299Search in Google Scholar

[53] Ravikumar S, Inbaneson SJ, Suganthi P, Gnanadesigan M. In vitro antiplasmodial activity of ethanolic extracts of mangrove plants from South East coast of India against chloroquine-sensitive Plasmodium falciparum. Parasitol Res. 2011;108:873–78.10.1007/s00436-010-2128-zSearch in Google Scholar

[54] Kathiresan K. Ravindran VS and MaruganathamV. Mangrove plant extract prevent the blood coagulate!. Indian J Biotech. April 2006;5:252–4.Search in Google Scholar

[55] Bunyapraphatsara N, Jutiviboonsuk V, Sornlek P, Therathanathorn W, Aksornkaew S, Fong HHS, et al. Pharmacological studies of plants in the mangrove. Thai J Phytopharmacy. 2003;10:1–12.Search in Google Scholar

[56] Ravikumar S, Ramanathan G, Gnanadesigan M. In vitro antiplasmodial activity of spiro benzofuran compound from mangrove plant of Southern India. Asian Pac J Trop Med. 2012;5(5):358–61.10.1016/S1995-7645(12)60059-5Search in Google Scholar

[57] Premanathan M, Nakashima H, Kathiresan K, Rajendra N, Yamamoto N. In vitro anti human immunodeficiency virus activity of mangrove plants. Indian J Med Res. 1996 May;103:278–81.Search in Google Scholar

[58] Premanathan M, Kathiresan K, Chandra K. Antiviral evaluation of some marine plants against Semliki Forest virus. Int J Pharmacognosy. 1995;33:75–7.10.3109/13880209509088153Search in Google Scholar

[59] Bakshi M, Chaudhuri P. Antimicrobial potential of leaf extracts of ten mangrove species from Indian sundarban. Int J Pharm Bio Sci. 2014 Jan;5:294–304.10.1007/s12668-015-0175-8Search in Google Scholar

[60] Ravikumar S, Ramanathan G, Subhakaran M, Inbaneson SJ. Antimicrobial compounds from marine halophytes for silkworm disease treatment. Int J Med Med Sci. 2009 May;1:184–91.Search in Google Scholar

[61] Ravikumar S, Syed Ali M, Ramu A, Ferosekhan M. Antibacterial activity of chosen mangrove plants against bacterial specified pathogens. World Appl Sci J. 2011;14:1198–202.Search in Google Scholar

[62] Uddin SJ, Rouf R, Shilpi JA, Alamgir M, Nahar L, Sarker SD. Screening of some Bangladeshi medicinal plants for in vitro antibacterial activity. Orient Pharm Exp Med. 2008;8:316–21.10.3742/OPEM.2008.8.3.316Search in Google Scholar

[63] Kumar VA, Ammani K, Siddhardha B. In vitro antimicrobial activity of leaf extracts of certain mangrove plants collected from Godavari estuarine of Konaseema delta. India Int J Med Arom Plants. 2011;1:132–6.Search in Google Scholar

[64] Nabeel MA, Kathiresan K, Manivannan S. Antidiabetic activity of the mangrove species Ceriops decandra in alloxan-induced diabetic rats. J Diabetes. 2010;2:97–103.10.1111/j.1753-0407.2010.00068.xSearch in Google Scholar PubMed

[65] Hossain MH, Hassan MM, Jahan IA, Nimmi I. Antidiarrhoeal activity, nitric oxide scavenging and total tannin content from the bark of Ceriops decandra (griff.) Ding hou. Int J Pharm Sci Res. 2012;3:1306–11.Search in Google Scholar

[66] Hossain H, Moniruzzaman S, Nimmi I, Kawsar H, Hossain A, Islam A, et al. Anti-inflammatory and antioxidant activities of the ethanolic extract of Ceriops decandra (Griff.) Ding Hou bark. Orient Pharm Exp Med. 2011 December;11:215–20.10.1007/s13596-011-0037-zSearch in Google Scholar

[67] Amudha P, Kumar V. Antimycobacterial activity of certain mangrove plants against multi-drug resistant Mycobacterium tuberculosis. Asian J Med Sci. 2014 Jul-Sep;5:54–7.10.3126/ajms.v5i3.9171Search in Google Scholar

[68] Uddin SJ, Shilpi JA, Barua V, Rouf V. Antinociceptive activity of Ceriops decandra leaf and pneumatophore. Fitoterapia. March 2005;76:261–3.10.1016/j.fitote.2004.12.015Search in Google Scholar PubMed

[69] Fabricant DS, Farnsworth NR. The value of plants used in traditional medicine for drug discovery. Environ Health Persp. 2001;109:69–75.10.1289/ehp.01109s169Search in Google Scholar

[70] Balunas MJ, Kinghorn AD. Drug discovery from medicinal plants. Life Sci. 2005;78:431–41.10.1016/j.lfs.2005.09.012Search in Google Scholar PubMed

[71] Rabi T, Bishayee A. Terpenoids and breast cancer chemoprevention. BreastCancerResTreat. 2009;115:223–39.10.1007/s10549-008-0118-ySearch in Google Scholar PubMed

[72] Wagner KH, Elmadfa I. Biological relevance of terpenoids. Overview focusing on mono-, di- and tetraterpenes. AnnNutr Metab. 2003;47:95–106.10.1159/000070030Search in Google Scholar PubMed

[73] Sultana N, Ata A. Oleanolic acid and related derivatives asmedicinally important compounds. J Enzyme Inhib Med Chem. 2008;23:739–56.10.1080/14756360701633187Search in Google Scholar PubMed

[74] Shah BA, Qazi GN, Taneja SC. Boswellic acids: a group of medicinally important compounds. Nat Prod Rep. 2009;26:72–89.10.1039/B809437NSearch in Google Scholar

[75] Setzer WN, Setzer MC. Plant-derived triterpenoids as potential antineoplastic agents. Mini Rev Med Chem. 2003;3:540–56.10.2174/1389557033487854Search in Google Scholar

[76] Laszczyk MN. Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy. Planta Med. 2009;75:1549–60.10.1055/s-0029-1186102Search in Google Scholar

[77] Petronelli A, Pannitteri G, Testa U. Triterpenoids as new promising anticancer drugs. Anticancer Drugs. 2009;20:880–92.10.1097/CAD.0b013e328330fd90Search in Google Scholar

[78] Dutra LM, Bomfim LM, Rocha SL, Nepel A, Soares MB, Barison A, et al. ent-Kaurane diterpenes from the stem bark of Annona vepretorum (Annonaceae) and cytotoxic evaluation Bioorg. Med Chem Lett. 2014;24:3315–20.10.1016/j.bmcl.2014.06.005Search in Google Scholar

[79] Costa-Lotufo LV, Cunha GM, Farias PA, Viana GS, Cunha KM, Pessoa C, et al. The cytotoxic and embryotoxic effects of kaurenoic acid, a diterpene isolated from Copaifera langsdorffii oleo-resin. 2002; 40(8): 1231–234.10.1016/S0041-0101(02)00128-9Search in Google Scholar

[80] Zhaomin Lin, Yanxia Guo, Yanhui Gao, Shuqi Wang, Xiaoning Wang, Zhiyu Xie, et al. ent-Kaurane diterpenoids from Chinese liverworts and their antitumor activities through Michael addition as detected in situ by a fluorescence probe. J Med Chem. 2015;58:3944–56.10.1021/acs.jmedchem.5b00208Search in Google Scholar PubMed

[81] Yang J, Wang WG, Wu HY, Du X, Li XN, Li Y, et al. Bioactive enmein-type ent-kaurane diterpenoids from Isodon phyllostachys. J Nat Prod. 2016;79:132–40.10.1021/acs.jnatprod.5b00802Search in Google Scholar PubMed

[82] Wang H, Li MY, Wu J. Chemical constituents and some biological activities of plants from the genus Ceriops. Chem Biodivers. 2012;9:1–11.10.1002/cbdv.201000299Search in Google Scholar PubMed

[83] Fronza M, Lamy E, Günther S, Heinzmann B, Laufer S, Merfort I. Abietane diterpenes induce cytotoxic effects in human pancreatic cancer cell line MIA PaCa-2 through different modes of action. Phytochemistry. 2012;78:107–19.10.1016/j.phytochem.2012.02.015Search in Google Scholar PubMed

[84] Marques CG, Pedro M, Simões MF, Nascimento MS, Pinto MM, Rodríguez B. Effect of abietane diterpenes from Plectranthus grandidentatus on the growth of human cancer cell lines. Planta Med. 2002;68:839–40.10.1055/s-2002-34407Search in Google Scholar PubMed

[85] Li L, Wu L, Wang M, Sun J, Liang J. Abietane diterpenoids from Clerodendrum trichotomum and correction of NMR data of villosin C and B. Nat Prod Commun. 2014;19:907–10.10.1177/1934578X1400900706Search in Google Scholar

[86] Lin CZ, Zhao W, Feng XL, Liu FL, Zhu CC. Cytotoxic diterpenoids from Rabdosia lophanthoides var. Gerardianus. Fitoterapia. 2016;2016:14–9.10.1016/j.fitote.2015.11.015Search in Google Scholar PubMed

[87] Ji L, Liu T, Liu J, Chen Y, Wang Z. Andrographolide inhibits human hepatoma-derived Hep3B cell growth through the activation of c-Jun N-terminal kinase. Planta Med. 2007;73:1397–401.10.1055/s-2007-990230Search in Google Scholar PubMed

[88] Abudula R, P B J, S E D R, Xiao J, Rebaudioside HK. A potently stimulates insulin secretion from isolated mouse islets: studies on the dose-, glucose-, and calciumdependency. Metabolism. 2004;53:1378–81.10.1016/j.metabol.2004.04.014Search in Google Scholar PubMed

[89] Johnson JJ, Syed DN, Heren CR, Suh Y, Adhami VM, Mukhtar H. Carnosol, a dietary diterpene, displays growth inhibitory effects in human prostate cancer PC3 cells leading to G2-phase cell cycle arrest and targets the 5ʹ-AMP-activated protein kinase (AMPK) pathway. Pharm Res. 2008;25:2125–34.10.1007/s11095-008-9552-0Search in Google Scholar PubMed PubMed Central

[90] Nagarajan A, Diterpenes-A BP. Review on therapeutic uses with special emphasis on antidiabetic activity. J Pharm Res. 2012;5:4530–40.Search in Google Scholar

[91] Fulda S. Betulinic acid: a natural product with anticancer activity. Mol Nutr Food Res. 2009;53:140–6.10.1002/mnfr.200700491Search in Google Scholar PubMed

[92] Setzer WN, Setzer MC, Bates RB, Jackes BR. Biologically active triterpenoids of Syncarpia glomulifera extract from Paluma, North Queensland, Australia. Planta Med. 2000;66:176–7.10.1055/s-2000-11129Search in Google Scholar PubMed

[93] Amico V, Barresi V, Condorelli D, Spatafora C, Tringali C. Antiproliferative terpenoids from almond hulls (Prunus dulcis): identification and structure-activity relationships. J Agric Food Chem. 2006;54:810–4.10.1021/jf052812qSearch in Google Scholar PubMed

[94] Rzeski W, Stepulak A, Szymański M, Sifringer M, Kaczor J, Wejksza K, et al. Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells. Naunyn-Schmeiedeberg’s Acrh Pharmacol. 2006;374:11–20.10.1007/s00210-006-0090-1Search in Google Scholar PubMed

[95] Basu S, Ma R, Boyle PJ, Mikulla B, Bradley M, Smith B, et al. Apoptosis of human carcinoma cells in the presence of potential anti-cancer drugs: III. Treatment of Colo-205 and SKB3 cells with: cis-platin, tamoxifen, melphalan, betulic acid, L-PDMP, L-PPMP, and GD3 ganglioside. Glycoconj J. 2004;20:563–77.10.1023/B:GLYC.0000043293.46845.07Search in Google Scholar

[96] Kessler JH, Mallauer FB, De Roo GM, Medema JP. Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types. Cancer Lett. 2007;251:132–45.10.1016/j.canlet.2006.11.003Search in Google Scholar

[97] Eichenmüller M, Von Schweinitz D, Kappler R. Betulinic acid treatment promotes apoptosis in hepatoblastoma cells. Int J Oncol. 2009;35:873–9.10.3892/ijo_00000402Search in Google Scholar

[98] Martelanc M, Vovk I, Simonovska B. Determination of three major triterpenoids in epicuticular wax of cabbage (Brassica oleracea L.) by high-performance liquid chromatography with UV and mass spectrometric detection. J Chromatogr A. 2007;1164:145–52.10.1016/j.chroma.2007.06.062Search in Google Scholar

[99] Bani S, Kaul A, Khan B, Ahmad SF, Suri KA, Gupta BD, et al. Suppression of T lymphocyte activity by lupeol isolated from Crataeva religiosa. Phytother Res. 2006;20:279–87.10.1002/ptr.1852Search in Google Scholar

[100] Latha RM, Lenin M, Rasool M, Varalakshmi P. A novel derivative pentacyclic triterpene and omega 3 fatty acid. Prost Leukot Essent Fatty Acids. 2001;64:81–5.10.1054/plef.2001.0245Search in Google Scholar

[101] Vasconcelos JF, Teixeira MM, Barbosa-Filho JM, Lúcio AS, Almeida JR, De Queiroz LP, et al. The triterpenoid lupeol attenuates allergic airway inflammation in a murine model. Int Immunopharmacol. 2008;8:1216–21.10.1016/j.intimp.2008.04.011Search in Google Scholar

[102] Sunitha S, Nagaraj M, Varalakshmi P. Hepatoprotective effect of lupeol and lupeol linoleate on tissue antioxidant defence system in cadmiuminduced hepatotoxicity in rats. Fitoterapia. 2001;72:516–23.10.1016/S0367-326X(01)00259-3Search in Google Scholar

[103] Nguemfo EL, Dimo T, Dongmo AB, Azebaze AG, Alaoui K, Asongalem AE, et al. Anti-oxidative and anti-inflammatory activities of some isolated constituents from the stem bark of Allanblackia monticola Staner L.C (Guttiferae). Inflammopharmacology. 2009;17:37–41.10.1007/s10787-008-8039-2Search in Google Scholar PubMed

[104] Sudhahar V, Ashok Kumar S, Varalakshmi P, Sujatha V. Protective effect of lupeol and lupeol linoleate in hypercholesterolemia associated renal damage. Mol Cell Biochem. 2008;317:11–20.10.1007/s11010-008-9786-5Search in Google Scholar PubMed

[105] Lima LM, Perazzo FF, Tavares Carvalho JC, Bastos JK. Anti-inflammatory and analgesic activities of the ethanolic extracts from Zanthoxylum riedelianum (Rutaceae) leaves and stem bark. J Pharm Pharmacol. 2007;59:1151–8.10.1211/jpp.59.8.0014Search in Google Scholar PubMed

[106] Akihisa T, Yasukawa K, Oinuma H, Kasahara Y, Yamanouchi S, Takido M, et al. Triterpene alcohols from the flowers of compositae and their anti-inflammatory effects. Phytochemistry. 1996;43:1255–60.10.1016/S0031-9422(96)00343-3Search in Google Scholar

[107] Davis RH, DiDonato JJ, Johnson RW, Stewart CB. Aloe vera, ydrocortisone and sterol influence on wound tensile strength and anti-inflammation. J Am Podiatr Med Assoc. 1994;84:614–21.10.7547/87507315-84-12-614Search in Google Scholar

[108] Ramirez Apan AA, Pérez-Castorena AL, De Vivar AR. Anti-inflammatory constituents of Mortonia greggii Gray. Z Naturforsch [C]. 2004;59:237–43.10.1515/znc-2004-3-421Search in Google Scholar

[109] Gupta R, Sharma AK, Sharma MC, Dobhal MP, Gupta RS. Evaluation of antidiabetic and antioxidant potential of lupeol in experimental hyperglycaemia. Nat Prod Res. 2012;26:1125–9.10.1080/14786419.2011.560845Search in Google Scholar

[110] Zhang L, Zhang Y, Zhang L, Yang X, Lv Z. Lupeol, a dietary triterpene, inhibited growth, and induced apoptosis through down-regulation of DR3 in SMMC7721 cells. Cancer Invest. 2009;27:163–70.10.1080/07357900802210745Search in Google Scholar

[111] Nagaraj M, Sunitha S, Varalakshmi P. Effect of lupeol a pentacyclic triterpene, on the lipid peroxidation and antioxidant status in rat kidney after chronic cadmium exposure. J Appl Toxicol. 2000;20:413–7.10.1002/1099-1263(200009/10)20:5<413::AID-JAT706>3.0.CO;2-YSearch in Google Scholar

[112] Lambertini E, Lampronti I, Penolazzi L, Khan MT, Ather A, Giorgi G, et al. Expression of estrogen receptor alpha gene in breast cancer cells treated with transcription factor decoy is modulated by Bangladeshi natural plant extracts. Oncol Res. 2005;14:69–79.10.3727/096504005775082057Search in Google Scholar

[113] Nigam N, Prasad S, Shukla Y. Preventive effects of lupeol on DMBA induced DNA alkylation damage in mouse skin. Food Chem Toxicol. 2007;45:2331–5.10.1016/j.fct.2007.06.002Search in Google Scholar

[114] Saleem M, Afaq F, Adhami VM, Mukhtar H. Lupeol modulates NF-kappa B and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice. Oncogene. 2004;23:5203–14.10.1038/sj.onc.1207641Search in Google Scholar

[115] Tsai FS, Lin LW, Wu CR. Lupeol and its role in chronic diseases. Adv Exp Med Biol. 2016;929:145–75.10.1007/978-3-319-41342-6_7Search in Google Scholar

[116] Cordova C, Gutierrez B, Martinez-Garcia C, Martin R, GallegoMunoz P, Hernandez M, et al. Oleanolic acid controls allergic and inflammatory responses in experimental allergic conjunctivitis. Plos One. 2014;9:e91282.10.1371/journal.pone.0091282Search in Google Scholar PubMed PubMed Central

[117] Wang Xin, Li Y-L, Wu H, Liu J-Z, Hu J-X, Liao N, et al. Antidiabetic effect of oleanolic acid: a promising use of a traditional pharmacological agent. Phytother Res. 2011;25:1031–40.10.1002/ptr.3385Search in Google Scholar PubMed

[118] Hsu HF, Houng JY, Chang CL, Wu CC, Chang FR, Wu YC. Antioxidant activity and DNA information of Glossogyne tenuifolia. J Agric Food Chem. 2005;53:6117–25.10.1021/jf050463uSearch in Google Scholar PubMed

[119] Matysik G, Wojciak-Kosior M, Paduch R. The influence of Calendulae officinalis flos extracts on cell cultures, and the chromatographic analysis of extracts. J Pharm Biomed Anal. 2005;38:285–92.10.1016/j.jpba.2004.12.034Search in Google Scholar PubMed

[120] Mencherini T, Picerno P, Festa M, Russo P, Capasso A, Aquino R. Triterpenoid constituents from the roots of Paeonia rockii ssp. Rockii J Nat Prod. 2011;74:2116–21.10.1021/np200359vSearch in Google Scholar PubMed

[121] Checker R, Sandur SK, Sharma D, Patwardhan RS, Jayakumar S, Kohli V, et al. Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-kB, AP-1 and NF-AT. Plos One. 2012;7:e31318.10.1371/journal.pone.0031318Search in Google Scholar PubMed PubMed Central

[122] Tang C, Lu YH, Xie JH, Wang F, Zou JN, Yang JS, et al. Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis. Anticancer Drugs. 2009;20:249–58.10.1097/CAD.0b013e328327d476Search in Google Scholar PubMed

[123] Liu JJ, Nilsson A, Oredsson S, Badmaev V, Duan RD. Keto-and acetyl-keto-boswellic acids inhibit proliferation andinduce apoptosis in Hep G2 cells via a caspase-8 dependent pathway. Int J Mol Med. 2002;10:501–5.10.3892/ijmm.10.4.501Search in Google Scholar

[124] Yan SL, Huang CY, Wu ST, Yin MC. Oleanolic acid and ursolicacid induce apoptosis in four human liver cancer celllines. Toxicol In Vitro. 2010;24:842–8.10.1016/j.tiv.2009.12.008Search in Google Scholar PubMed

[125] Shyu MH, Kao TC, Yen GC. Oleanolic acid and ursolicacid induce apoptosis in HuH7 human hepatocellular carcinomacells through a mitochondrial-dependent pathwayand downregulation of XIAP. J Agric Food Chem. 2010;58:6110–8.10.1021/jf100574jSearch in Google Scholar PubMed

[126] Otuki MF, Vieira-Lima F, Malheiros A, Yunes RA, Calixto JB. Topical antiinflammatory effects of the ether extract from Protium kleinii and α-amyrin pentacyclic triterpene. Eur J Pharmacol. 2005;507:253–9.10.1016/j.ejphar.2004.11.012Search in Google Scholar PubMed

[127] Medeiros R, Otuki MF, Avellar MCW, Calixto JB. Mechanisms underlying the inhibitory actions of the pentacyclic triterpene α-amyrininthemouseskininflammation induced by phorbol ester 12-O-tetradecanoylphorbol-13acetate. Eur J Pharmacol. 2007;559:227–35.10.1016/j.ejphar.2006.12.005Search in Google Scholar

[128] Xiang LP, Wang A, Ye JH. Suppressive effects of tea catechins on breast cancer. Nutrients. 2016;8:458.10.3390/nu8080458Search in Google Scholar

[129] Slivova V, Zaloga G, DeMichele SJ, Mukerji P, Huang YS, Siddiqui R, et al. Green tea polyphenols modulate secretion of urokinase plasminogen activator (uPA) and inhibit invasive behavior of breast cancer cells. Nutr Cancer. 2005;52:66–73.10.1207/s15327914nc5201_9Search in Google Scholar

[130] Rice-Evans CA, Miller NJ, Paganga G. Structure antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med. 1996;20:933–56.10.1016/0891-5849(95)02227-9Search in Google Scholar

[131] Bors W, Michel C. Chemistry of the antioxidant effect of polyphenols. Ann N Y Acad Sci. 2002;957:57–69.10.1111/j.1749-6632.2002.tb02905.xSearch in Google Scholar

[132] Ito H, Kobayashi E, Takamatsu Y, Li SH, Hatano T, Sakagami H, et al. Polyphenols from Eriobotrya japonica and their cytotoxicity against human oral tumor cell lines. Chem Pharm Bull. 2000;48:687–93.10.1248/cpb.48.687Search in Google Scholar

[133] Santos-Buelga C, Scalbert A. Proanthocyanidins and tannin-like compounds – nature, occurrence, dietary intake and effects on nutrition and health. J Sci Food Agric. 2000;80:1094–117.10.1002/(SICI)1097-0010(20000515)80:7<1094::AID-JSFA569>3.0.CO;2-1Search in Google Scholar