Pharmacological potentials of betalains

References

[1] Georgiev VG, Weber J, Kneschke EM, Denev PN, Bley T, Pavlov A. Antioxidant activity and phenolic content of betalain extract from intact plants and hairy root cultures of the red beetroot Beta vulgaris cv. Detroit Dark Red. 2010;65:105–11.10.1007/s11130-010-0156-6Suche in Google Scholar

[2] Nottingham S 2004. Beetroot e-book- 2004. The Times, London. http://stephennottingham.co.uk Accessed 28 Jan 2011.Suche in Google Scholar

[3] Escribano J, Pedreno MA, Garcia-Carmona F, Munoz R. Characterization of the antiradical activity of betalains from Beta vulgaris L. roots. Phytochem Anal. 1998;9:124–27.10.1002/(SICI)1099-1565(199805/06)9:3<124::AID-PCA401>3.0.CO;2-0Suche in Google Scholar

[4] Kanner J, Harel S, Granit R. Betalains—a new class of dietary cationized antioxidants. J Agric Food Chem. 2001;49:5178–85.10.1021/jf010456fSuche in Google Scholar PubMed

[5] Kasiri M, Safapour S. Exploring and exploiting plants extracts as the natural dyes/antimicrobials in textiles processing. Prog Color Colorants Coat. 2015;8:87–114.Suche in Google Scholar

[6] Schliemann W, Kobayashi N, Strack D. The decisive step in betaxanthin biosynthesis Is a spontaneous reaction1. Plant Physiology. 1999;119:1217–32. DOI:10.1104/pp.119.4.1217Suche in Google Scholar PubMed

[7] Pietrzkowski Z, Nemzer B, Spórna A, Stalica P, Tresher W, Keller R, et al. Influence of betalin-rich extracts on reduction of discomfort associated with osteoarthritis. New Med. 2010;1:12–17.Suche in Google Scholar

[8] De La Torre JC, Stefano GB. Evidence that Alzheimer’s disease is a microvascular disorder: the role of constitutive nitric oxide. Brain Res Rev. 2000;34:119–36.10.1016/S0165-0173(00)00043-6Suche in Google Scholar

[9] Gilchrist M, Winyard PG, Fulford J, Anning C, Shore AC, Benjamin N. Dietary nitrate supplementation improves reaction time in type 2 diabetes: development and application of a novel nitrate-depleted beetroot juice placebo. Nitric Oxide: Biol Chem. 2014;40:67–74.10.1016/j.niox.2014.05.003Suche in Google Scholar

[10] Strack D, Steglich W, Wray V. Betalains. In: Dey PM, Harborne JB, editors. Methods in plant biochemistry, vol. 8, Alkaloids and sulphur compounds, (Waterman, P.G., Ed.). London: Academic Press, 1993:421–50.Suche in Google Scholar

[11] Toutain PL, Bousquet-Mélou A. A bioavailability and its assessment. J Vet Pharmacol Ther. 2004;27:455–66.10.1111/j.1365-2885.2004.00604.xSuche in Google Scholar PubMed

[12] Frank T, Stintzing FC, Carle R, Bitsch I, Quaas D, Strass G, et al. Urinary pharmacokinetics of betalains following consumption of red beet juice in healthy humans. Pharmacol Res. 2005;52:290–97.10.1016/j.phrs.2005.04.005Suche in Google Scholar PubMed

[13] El Gamal Ali A, AlSaid Mansour S, Raish Mohammad, Al-Sohaibani Mohammed, Al-Massarani Shaza M, Ahmad Ajaz, Hefnawy Mohamed, Al-Yahya Mohammed, Basoudan Omer A, Rafatullah Syed, et al. Beetroot (Beta vulgarisL.) extract ameliorates gentamicin-induced nephrotoxicity associated oxidative stress, inflammation, and apoptosis in rodent model. Mediators Inflam. 2014;2014:1–12. DOI: 10.1155/2014/983952Suche in Google Scholar

[14] Schliemann W, Joy RW, IV, Komamine A, Metzger JW, Nimtz M, Wray V, et al. Betacyanins from plants and cell cultures of Phytolacca americana. Phytochemistry. 1996;42:1039–46.10.1016/0031-9422(96)00100-8Suche in Google Scholar PubMed

[15] Degenhardt A, Winterhalter P. Isolation of natural pigments by high speed CCC. J Liq Chromatogr. 2001;24:1745–64.10.1081/JLC-100104376Suche in Google Scholar

[16] Amster IJ. Fourier transform mass spectrometry. J Mass Spectrom. 1996;31:1325–37.10.1002/(SICI)1096-9888(199612)31:12<1325::AID-JMS453>3.0.CO;2-WSuche in Google Scholar

[17] Wootton-Beard PC, Ryan L. A beetroot juice shot is a significant and convenient source of bioaccessible antioxidants. J Funct Foods. 2011;3:329–34.10.1016/j.jff.2011.05.007Suche in Google Scholar

[18] Tang Y, Li X, Zhang B, Chen PX, Liu R, Tsao R. Characterisation of phenolics, betanins and antioxidant activities in seeds of three Chenopodium quinoa Willd. Genotypes Food Chem. 2015;166:380–88.10.1016/j.foodchem.2014.06.018Suche in Google Scholar

[19] Escribano J, Cabanes J, Jiménez-Atiénzar M, Ibañez-Tremolada M, Gómez-Pando LR, García-Carmona F, et al. Characterization of betalains, saponins and antioxidant power in differently colored quinoa (Chenopodium quinoa) varieties. Food Chem. 2017;234:285–94.10.1016/j.foodchem.2017.04.187Suche in Google Scholar PubMed

[20] Wybraniec S, Wydra BN, Mitka K, Kowalski P, Mizrahi Y. Minor betalains in fruits of Hylocereus species. Phytochemistry. 2007;68:251–59.10.1016/j.phytochem.2006.10.002Suche in Google Scholar PubMed

[21] Khatabi O, Hanine H, Elothmani D, Hasib A. Extraction and determination of polyphenols and betalain pigments in the Moroccan Prickly pear fruits (Opuntia ficus indica). Arabian J Chem. 2016;9:S278–S281.10.1016/j.arabjc.2011.04.001Suche in Google Scholar

[22] Thirugnanasambandham K, Sivakumar V. Microwave assisted extraction process of betalain from dragon fruit and its antioxidant activities. J Saudi Soc Agr Sci. 2017;16:41–8.10.1016/j.jssas.2015.02.001Suche in Google Scholar

[23] Sreekanth D, Arunasree MK, Roy KR, Reddy TC, Reddy GV, Reddannav P. Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia Cell line-K562. Phytomedicine. 2007;14:739–46.10.1016/j.phymed.2007.03.017Suche in Google Scholar PubMed

[24] Tan D, Wang Y, Bai B, Yang X, Han J. Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquat-treated rat. Food Chem Toxicol. 2015;78:141–46.10.1016/j.fct.2015.01.018Suche in Google Scholar PubMed

[25] Kujawska M, Ignatowicz E, Murias M, Ewertowska M, Mikołajczyk K, Jodynis-Liebert J. Protective effect of red beetroot against carbon tetrachloride- and N-nitrosodiethylamine-induced oxidative stress in rats. J Agric Food Chem. 2009;57:2570–75.10.1021/jf803315dSuche in Google Scholar PubMed

[26] Szaefer H, Krajka-Kuźniak V, Ignatowicz E, Adamska T, Baer-Dubowska W. Evaluation of the effect of beetroot juice on DMBA-induced damage in liver and mammary gland of female Sprague-Dawley rats. Phytother Res. 2014;28:55–61.10.1002/ptr.4951Suche in Google Scholar PubMed

[27] Winkler C, Wirleitner B, Schroecksnadel K. In vitro effects of beet root juice on stimulated and unstimulated peripheral blood mononuclear cells. Am J Biochem Biotechnol. 2005;1:180.10.3844/ajbbsp.2005.180.185Suche in Google Scholar

[28] Bond V, Curry Bryan H, Adams Richard G, Asadi M. Sadegh, Millis Richard M, Haddad Georges E. Effects of dietary nitrates on systemic and cerebrovascular hemodynamics. Cardiol Res Pract. 2013;2013:1–9. DOI: 10.1155/2013/435629Suche in Google Scholar PubMed PubMed Central

[29] Spilt A, Weverling-Rijnsburger AWE, Middelkoop HAM, Van Der Flier WM, Gussekloo J, De Craen AJM, et al. Late-onset dementia: structural brain damage and total cerebral blood flow. Radiology. 2005;236:990–95.10.1148/radiol.2363041454Suche in Google Scholar PubMed

[30] Bondonno Catherine P., et al. The acute effect of flavonoid-rich apples and nitrate-rich spinach on cognitive performance and mood in healthy men and women. Food Funct.. 2014;5(5):849–858. DOI: 10.1039/c3fo60590f.Suche in Google Scholar PubMed

[31] Kelly J, Fulford J, Vanhatalo A, Blackwell JR, French O, Bailey SJ, et al. Effects of short-term dietary nitrate supplementation on blood pressure, O₂ uptake kinetics, and muscle and cognitive function in older adults. Am J Physiol. 2013;304:73–83.10.1152/ajpregu.00406.2012Suche in Google Scholar PubMed

[32] InRodent Model as Tools in Ethical Biomedical Research. Behavioral methods to study learning and memory in rats. 2006:271–311.Suche in Google Scholar

[33] Jorge AQ. In Rodent Model as tools in ethical biomedical research. Behavioral methods to study learning and memory in rats. Cham: Springer International Publishing, 2006:271–311.Suche in Google Scholar

[34] Murthy KN, Manchali S. Anti-diabetic potentials of red beet pigments and other constituents. In: Neelwarne B, editor. Red beet biotechnology: foods and pharmaceuticals applications, Chapter 8. New York: Springer Science+business Media, 2012:155–74.10.1007/978-1-4614-3458-0_8Suche in Google Scholar

[35] Wootton-Beard PC, Brandt K, Fell D, Warner S, Ryan L. Effects of a beetroot juice with high neobetanin content on the early-phase insulin response in healthy volunteers. J Nat Sci. 2014;3:1–9.10.1017/jns.2014.7Suche in Google Scholar PubMed PubMed Central

[36] Wang CQ, Yang GQ. Betacyanins from Portula caoleracea L. ameliorate cognition deficits and attenuate oxidative damage induced by D-galactose in the brains of senescent mice. Phytomedicine. 2010;17:527–32.10.1016/j.phymed.2009.09.006Suche in Google Scholar PubMed

[37] Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrates and beetroot juice supplementation reduces blood pressure in adults: a systemic review and meta-analysis. J Nutr Am Soc Nutr. 2013;143::818–26.10.3945/jn.112.170233Suche in Google Scholar PubMed

[38] Escribano J, Garcia-Carmona F. Biological activities of plant pigments betalains. J Crit Rev Food Sci Nutr. 2014;56:937–45.10.1080/10408398.2012.740103Suche in Google Scholar PubMed

[39] Indumathi D, Sujithra K, Srinivasan S, Vinothkumar V. Ameliorating effect of betanin, a natural chromoalkaloid by modulating hepatic carbohydrate metabolic enzyme activities and glycogen content in streptozotocin – nicotinamide induced experimental rats. Biomed Pharmacother. 2017;18:1069–79.10.1016/j.biopha.2017.01.146Suche in Google Scholar

[40] Lansley KE, Winyard PG, Bailey SJ, Vanhatalo A, Wilkerson DP, Blackwell JR, et al. Acute dietary nitrate supplementation improves cycling time trial performance. Med Sci Sports Exerc Rapid Commu. 2011;43:1125–31.10.1249/MSS.0b013e31821597b4Suche in Google Scholar PubMed

[41] Cermak NM, Gibala MJ, Van Loon LJC. Nitrate supplementation’s improvement of 10-km time-trial performance in trained cyclists. Int J Sports Nutr Exerc. 2012;22:64–71.10.1123/ijsnem.22.1.64Suche in Google Scholar PubMed

[42] Xiaoling L, Yuping W, Zesheng Z. Radioprotective activity of betalains from red beets in mice exposed to gamma irradiation. Eur J Pharmacol. 2009;615:223–27.10.1016/j.ejphar.2009.04.064Suche in Google Scholar PubMed

[43] Baldassano S, Rotondo A, Serio R, Livrea MA, Tesoriere L, Mule F. Inhibitory effects of indicaxanthin on mouse ileal contractility: analysis of the mechanism of action. Eur J Pharmacol. 2011;658:200–05.10.1016/j.ejphar.2011.02.034Suche in Google Scholar PubMed

[44] Khan MI, Joseph KMD, Muralidharadelete, Ramesh HP, Giridhar P, Ravishankar GA. Acute, subacute and subchronic safety assessment of betalains rich Rivina humilis L. berry juice in rats. Food Chem Toxicol. 2011;49:3154–57.10.1016/j.fct.2011.08.022Suche in Google Scholar PubMed

[45] Tesoriere L, Allegra M, Butera D, Livrea MA. Absorption, excretion, and distribution of dietary antioxidant betalains in LDLs: potential health effects of betalains in humans. Am J Clin Nutr. 2004;80:941–45.10.1093/ajcn/80.4.941Suche in Google Scholar PubMed

[46] Clifford T, Constantinou CM, Keane KM, West DJ, Howatson G, Stevenson EJ. The plasma bioavailability of nitrate and betanin from Beta vulgaris rubra in humans. Eur J Nutr. 2017;56:1245–54.10.1007/s00394-016-1173-5Suche in Google Scholar PubMed PubMed Central

[47] Lundberg JO, Larsen FJ, Weitzberg E. Supplementation with nitrate and nitrite salts in exercise: a word of caution. J Appl Physiol. 2011;111:616–17.10.1152/japplphysiol.00521.2011Suche in Google Scholar PubMed

[48] Jones AM. Dietary nitrate supplementation and exercise performance. Sports Med. 2014;44:35–45.10.1007/s40279-014-0149-ySuche in Google Scholar PubMed PubMed Central

[49] Martins N, Roriz CL, 1, Morales P, Barros L, 1, Ferreira IC, 1. Coloring attributes of betalains: a key emphasis on stability and future applications. Food Funct. 2017;1172:5300–253.10.1039/C7FO00144DSuche in Google Scholar

[50] Khan MI. Plant betalains: safety, antioxidant activity, clinical efficacy and bioavailability. Food Sci Food Saf. 2015;1111:1541–4337.10.1111/1541-4337.12185Suche in Google Scholar PubMed