The beneficial effects of pumpkin extract on atherogenic lipid, insulin resistance and oxidative stress status in high-fat diet-induced obese rats
Abstract
Background
Prevention and treatment of obesity is a way to reduce cardiovascular disease, diabetes and depression. Pumpkin as a favorable plant has different properties notably antioxidant, lipid-lowering and anti-diabetic potential. The aim of this study was to assess the anti-obesity effects of pumpkin in diet-induced obese rats.
Methods
Thirty adult male Wistar rats were randomly divided into five groups (n=6) of healthy control, dietary fatty control rats, and three experimental dietary fatty rats that received hydro-alcoholic extract of pumpkin once daily at doses 100 and 200 and 400 mg/kg, respectively. At the end of 6 weeks, lipid profile, atherogenicity, liver enzymes, and oxidative stress status were measured.
Results
Pumpkin in a dose-dependent manner dramatically decreased triglycerides and low-density lipoprotein, and liver enzymes while high-density lipoprotein was markedly increased in treated groups. Pumpkin also increased glutathione level in comparison with obese control group.
Conclusions
Pumpkin ameliorated oxidative stress and dyslipidemia in obese rats, leading to decrease cardiovascular disease risk in obesity.
Funding statement: This investigation was supported by Grant No. 77.93 from the office of Vice Chancellor research, Birjand University of Medical Sciences.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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Artikel in diesem Heft
- Review
- The effect of celery (Apium graveolens L.) on fertility: A systematic review
- Preclinical Studies
- Walnut leaf extract acts as a fertility agent in male Wistar albino rats – A search for herbal male fertility enhancer
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- Role of caftaric acid in lead-associated nephrotoxicity in rats via antidiuretic, antioxidant and anti-apoptotic activities
- Clinical Studies
- Effect of mindfulness meditation on short-term weight loss and eating behaviors in overweight and obese adults: A randomized controlled trial
- Evaluation of serum beta-endorphin and substance P in knee osteoarthritis patients treated by laser acupuncture
- Efficacy of Tamarindus indicus, Melia azadirach and Santalum album in syndromic management of abnormal vaginal discharge: A single-blind randomised controlled trial
- Complementary and alternative medicine usage and its determinant factors among Iranian infertile couples
- Short Communication
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