Emblica officinalis – Anti-obesity activity
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Iram Nazish
und
Shahid H Ansari
Abstract
Context
Emblica officinalis Gaertn. (family-Phyllanthaceae) fruits, known commonly as amla, is extensively used in Indian traditional system of medicine for the treatment of various disorders. The ethanolic E. officinalis extract is reported to have various activity such as antidiabetic, antihyperlipidemic and antioxidant activity in experimental animals.
Objective
To evaluate anti-obesity effect of aqueous E. officinalis extract in murine model of high fat diet (HFD)-induced obesity.
Materials and methods
Male Wistar rats fed with HFD (20 g/day/rat, p.o) for a period of 42 days were used to induce obesity. Aqueous E. officinalis extract (20 mg/kg bw) administered orally to HFD-fed rats from day 8 to 50 days for a period of 42 days. Body weight gain, serum lipids, insulin and leptin parameters were measured.
Results
Oral feeding of the aqueous E. officinalis extract (20 mg/kg) to HFD-induced obese rats for a period of 42 days resulted in significant reduction in body weight gain, insulin, leptin, lipids as compared to rats fed HFD alone. Further, the extract also showed significant increase in high density lipoprotein (HDL-C) levels.
Discussion and conclusions
These results show that aqueous E. officinalis extract possess significant anti-obesity potential.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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- The effect of celery (Apium graveolens L.) on fertility: A systematic review
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- Emblica officinalis – Anti-obesity activity
- The beneficial effects of pumpkin extract on atherogenic lipid, insulin resistance and oxidative stress status in high-fat diet-induced obese rats
- Comparison of anticancer effect of Pleurotus ostreatus extract with doxorubicin hydrochloride alone and plus thermotherapy on erythroleukemia cell line
- Role of caftaric acid in lead-associated nephrotoxicity in rats via antidiuretic, antioxidant and anti-apoptotic activities
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- Evaluation of serum beta-endorphin and substance P in knee osteoarthritis patients treated by laser acupuncture
- Efficacy of Tamarindus indicus, Melia azadirach and Santalum album in syndromic management of abnormal vaginal discharge: A single-blind randomised controlled trial
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