Antidiabetic and in vitro antioxidant effects of hydromethanol extract of Paullinia pinnata root bark in alloxan-induced diabetic rat

References

[1] Dandekar SP. Medical biochemistry, 2nd ed. India: Elsevier; 2002.Search in Google Scholar

[2] Center for Disease Control. National diabetes facts sheet, 2011. Accessed 1st March, 2015 www.cdc.gov/diabetes/pubs/pdf/ndfs_2011.pdf.Search in Google Scholar

[3] Onoja SO, Anaga AO. Evaluation of the antidiabetic and antioxidant potentials of methanolic leaf extract of Helianthus annuus L. on alloxan-induced hyperglycemic rats. Comp Clin Pathol. 2014;23:1565–73.10.1007/s00580-013-1824-3Search in Google Scholar

[4] Wild S, Roglic G, Green A, Sicree R, King HO. Global prevalence of diabetes: estimate for the year 2000 and projection for 2030. Diab Care. 2004;27:1047–53.10.2337/diacare.27.5.1047Search in Google Scholar

[5] Hofsø D, Jenssen T, Hager H, Røislien J, Hjelmesaeth J. Fasting plasma glucose in the screening for type 2 diabetes in morbidly obese subjects. Obes Surg. 2010;20:302–07.10.1007/s11695-009-0022-5Search in Google Scholar PubMed

[6] Rang HP, Dale MM, Ritter JM, Moore RK. Pharmacology, 5th ed. Edinburgh: Churchill Livingstone; 2003.Search in Google Scholar

[7] Kamesawara BR, Giri R, Kesavulu MM, Apparao CH. Effect of oral administration of bark extracts of Pterocarpus santalinus L. on blood glucose level in experimental animals. J Ethnopharmacol. 2000;74:69–74.10.1016/S0378-8741(00)00344-5Search in Google Scholar

[8] Onoja SO, Omeh YN, Ezeja MI, Odo EC, Elendu DS. Sub-acute antidiabetic and in vivo antioxidant effects of methanolic extract of Ficus glumosa stem bark on alloxan-induced hyperglycaemic rats. Comp Clin Pathol. 2014;23:1689–95.10.1007/s00580-014-1896-8Search in Google Scholar

[9] Adika OA, Madubunyi II, Asuzu IU. Antidiabetic and antioxidant effects of the methanol extract of Bridelia micrantha (Hochst) Baill. (Euphorbiaceae) leaves on alloxan-induced diabetic albino mice. Comp Clin Pathol. 2012;21:945–51.10.1007/s00580-011-1205-8Search in Google Scholar

[10] Aladodo RA, Muhammad NO, Balogun EA. Effects of aqueous root extract of Jatropha curcas on hyperglycaemic and haematological indices in alloxan-induced diabetic rats. Fountain J Nat Appl Sci. 2013;2:52–58.10.53704/fujnas.v2i1.39Search in Google Scholar

[11] Anaga AO, Asuzu IU. Antihyperglycaemic properties of the ethyl acetate extract of Dennettia tripetala in normal and diabetic rat. J Compl Integr Med. 2010;34:239–44.10.2202/1553-3840.1244Search in Google Scholar

[12] Ezeigbo II, Asuzu IU. Anti-diabetic activities of the methanol leaf extracts of Hymenocardia acida (Tul.) in alloxan-induced diabetic rats. Afr J Tradit Complement Altern Med. 2012;9:204–09.10.4314/ajtcam.v9i2.4Search in Google Scholar PubMed PubMed Central

[13] Ezeja MI, Anaga AO, Asuzu IU. Acute and sub-chronic toxicity profile of methanol leaf extract of Gouania longipetala in rats. J Ethnopharmacol. 2014;151:1155–64.10.1016/j.jep.2013.12.034Search in Google Scholar PubMed

[14] Madubunyi II, Onoja SO, Asuzu IU. In vitro anti-oxidant and in vivo anti-diabetic potentials of the methanol extract of Ficus glumosa Del (Moraceae) stem bark in alloxan-induced diabetic mice. Comp Clin Pathol. 2012;21:389–94.10.1007/s00580-010-1103-5Search in Google Scholar

[15] Ior LD, Uguru MO, Olotu PN. Ohemu TL and Ukpe A. Evaluation of analgesic and anti-inflammatory activities and phytochemical screening of the leaves extract of Paullinia pinnata (Sapindaceae). J Chem Pharm Res. 2011;3:351–56.Search in Google Scholar

[16] Annan K, Dickson RA, Amponsah IK, Jato J, Nooni IK. Pharmacognostic evaluation and physicochemical analysis of Paullinia pinnata L. (Sapindaceae). J Pharmacogn Phytochem. 2013;2:203–08.Search in Google Scholar

[17] Fred-Jaiyesimi AA, Larvicidal AO. Activities of the Extract and fractions of Paullinia pinnata Linn leaf. Phcog Commn. 2011;1:37–40.10.5530/pc.2011.2.7Search in Google Scholar

[18] Lunga PK, Tamokou JD, Fodouop SPC, Kuiate JR. Tchoumboue J and Gatsing D. Antityphoid and radical scavenging properties of the methanol extracts and compounds from the aerial part of Paullinia pinnata. Springer Plus. 2014;3:302.10.1186/2193-1801-3-302Search in Google Scholar

[19] Osarenmwinda IP, Omonkhelin JO, Ejiro D. Antidiarrhoeal activity of the methanolic extract of the leaves of Paullina pinnata linn (Sapindaceae). Int J Health. 2008;9:1.10.5580/10d7Search in Google Scholar

[20] Kofi A. Stephen G and Francis A. Antibacterial and radical scavenging activity of fatty acids from Paullinia pinnata L. Pharmacogn Mag. 2009;5:119–23.Search in Google Scholar

[21] DHHS. Guide for the care and use of laboratory animals, Institute of laboratory animal resources commission on life sciences, national research council. Washington, DC: National Academy Press; 1985.Search in Google Scholar

[22] Trease GE, Evans WC. Pharmacognosy, 15th ed. London: W. B. Saunders; 2002.Search in Google Scholar

[23] OECD. Guidelines for the testing of chemicals, acute oral toxicity – up-and down- procedure, no. 425, Adopted 3, October 2008.Search in Google Scholar

[24] Prince PS, Moon VP. Hypoglycemic and other related action of Tinospora codifolia roots in alloxan-induced diabetic rats. J Ethnopharmacol. 2000;70:19–25.10.1016/S0378-8741(99)00136-1Search in Google Scholar

[25] Ho KY, Tsai CC, Chen CP, Huang JS, Lin CC. Screening of Brazilian plant extracts for antioxidant activity by the use of DPPH free radical method. Phytother Res. 2001;15:127–30.10.1002/ptr.687Search in Google Scholar PubMed

[26] Iwalewa EO, Adewale IO, Taiwo BJ, Arogundade T, Osinowo A, Daniyan OM, et al. Effects of Harungana madagascariensis Stem Bark Extract on the Antioxidant Markers in Alloxan Induced Diabetic and Carrageenan Induced Inflammatory Disorders in Rats. Journal of Complementary and Integrative Medicine. 2008 1 21;5(1). DOI: 10.2202/1553-3840.1088.Search in Google Scholar

[27] Zamble A, Carpentier M, Kandoussi A, Sahpaz S, Petrault O, Ouk P, et al. Paullinia pinnata extracts rich in polyphenols promote vascular relaxation via endothelium-dependent mechanisms. J Cardiovasc Pharmacol. 2006;47:599–608.10.1097/01.fjc.0000211734.53798.1dSearch in Google Scholar

[28] Szkudelski T. The mechanism of alloxan and streptozotocin action in B-cell of the Rats pancreas. Physiol Res. 2001;50:536–46.10.33549/physiolres.930111Search in Google Scholar

[29] Anaga AO, Onuoha A, Igboeli OO, Ezeja M. Antihyperglycemic effects of the methanol leaf extract of Diaphananthe bidens in normoglycemic and streptozotocin-induced hyperglycemic rats. Asian Pac J Trop Med. 2012;5:192–96.10.1016/S1995-7645(12)60023-6Search in Google Scholar PubMed

[30] Mohammed A, Adelaiye AB, Ms A, Em A. Effects of aqueous extract of Ganoderma lucidum on blood glucose levels of normoglycemic and alloxaninduced diabetic wistar rats. J Med Plant Res. 2007;1:34–37.Search in Google Scholar

[31] Sepici-Dincel A, Ac¸Ikgöz S, Cevik C, Sengelen M, Yes¸Ilada E. Effects of in vivo antioxidant enzyme activities of myrtle oil in normoglycaemic and alloxan diabetic rabbits. J Ethnopharmacol. 2007;110:498–503.10.1016/j.jep.2006.10.015Search in Google Scholar PubMed

[32] Kim W, Egan JM. The Role of Incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev. 2008;60:470–512.10.1124/pr.108.000604Search in Google Scholar PubMed PubMed Central

[33] Garber AJ. Incretin effects on b-cell function, replication, and mass: the human perspective. Diab Care. 2011;34:S258–S263.10.2337/dc11-s230Search in Google Scholar PubMed PubMed Central

[34] Toft-Nielsen MB, Madsbad S, Holst JJ. Determinants of the effectiveness of glucagon like peptide-1 in type 2 diabetes. J Clin Endocrinol Metab. 2001;86:3853–60.10.1210/jcem.86.8.7743Search in Google Scholar PubMed

[35] Højberg P. V., Zander M., Vilsbøll T., Knop F. K., Krarup T., Vølund A., et al. Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes. Diabetologia. 2008 2 22;51:632–640.10.1007/s00125-008-0943-xSearch in Google Scholar PubMed

[36] Vilsbøll T, Krarup T, Madsbad S, Holst JJ. Defective amplification of the late phase insulin response to glucose by GIP in obese type II diabetic patients. Diabetologia. 2002;45:1111–19.10.1007/s00125-002-0878-6Search in Google Scholar PubMed