A study of pulmonary function in hypothyroid female patients of reproductive age group and its correlation with free T3, T4 and TSH
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Abstract
Objectives
Hypothyroidism is common among females of reproductive age group. The prevalence is 10.95 % of which 3.47 % are unaware of the condition and its effect on lung function. To study the pulmonary function among hypothyroid females of reproductive age group and to identify the respiratory disease pattern and also to correlate free T3, T4 and TSH Levels with pulmonary function test parameters.
Methods
This is a case control study, comprised of 156 participants divided into two groups (n1 and n2). Group 1 consisted of normal healthy female controls and group 2 consisted of hypothyroid female patients of age group 18–45 years. After recording anthropometric variables, vital signs and BMI, spirometry was performed and following parameters, FVC, FEV1, FEV1/FVC, PEF, PIF and FEF25–75 % were assessed and analyzed. Statistical analysis and correlation was done.
Results
Hypothyroid patients showed a statistically significant decline in FEV1, FEV1/FVC%. Rho and Pearson’s correlation showed a positive correlation between free T4 and FEV1, FEV1/FVC%, PIF, FEF25–75 %, with FEF25–75 % statistically significant. TSH showed a negative correlation with FVC, PEF and PIF with PEF statistically significant.
Conclusions
Our study shows that patients with hypothyroidism are more prone to develop obstructive pattern of lung disease, with a decline in small airway and large airway function.
Acknowledgments
We would like to express our heartfelt gratitude to the Institution, the Department of Physiology, and the study participants for their invaluable contributions, which were instrumental in the successful completion of this study.
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Research ethics: The study was approved by Institutional ethics committee and the Ethics clearance number is SRMIEC-ST0723-559.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Use of Large Language Models, AI and Machine Learning Tools: No AI or machine learning tools, including large language models, were used in the generation of content or analysis in this study.
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Conflict of interest: Authors state no conflict of interest.
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Research funding: None declared.
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Data availability: Not applicable.
References
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Artikel in diesem Heft
- Frontmatter
- Minireview
- Mental toughness and athletic performance: a narrative review
- Reviews
- The role of the urinary microbiome in diabetes-associated UTIs: current understanding and future directions
- Interleukin-23 (IL-23) inhibitor, mirikizumab in the treatment of ulcerative colitis (UC): a promising therapy?
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- Menopause, estrogen, and GERD: an exploration of symptoms and endoscopic correlations
- A study of pulmonary function in hypothyroid female patients of reproductive age group and its correlation with free T3, T4 and TSH
- A retrospective observational study to evaluate the association between self-reported binge alcohol drinkers and asthma
- Two hours of urine output are a reliable parameter for intravenous furosemide adequacy and the need for doubling dose in acute heart failure: a prospective study
- Physiological belching during impedance-pH monitoring: a meal with Coca-Cola provokes a prompt gastroesophageal reaction with increased prandial belching
