Two hours of urine output are a reliable parameter for intravenous furosemide adequacy and the need for doubling dose in acute heart failure: a prospective study
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Abstract
Objectives
This study compared urine output at 2 and 6 h post-furosemide and explored factors influencing diuretic efficacy in acute heart failure (AHF).
Methods
A prospective study (June–August 2023) included AHF patients (≥18 years) with NT-proBNP ≥300 pg/mL. Urinary spot sodium and urine output were measured at baseline, 2, and 6 h after 40 mg IV furosemide.
Results
Among 32 patients, 26 (81.25 %) had satisfactory urine output, and 30 (93.75 %) met the target urinary sodium concentration at 2 h. No significant difference in mean urine output was found between the 2 and 6 h intervals (267 ± 189 mL vs. 298 ± 149 mL, p=0.099). Urine output correlated strongly with urinary sodium concentration (p < 0.001, R2=0.683). Serum creatinine was a significant predictor of urine output (p=0.007).
Conclusions
The comparable urine output at 2 and 6 h suggests that a 2 h assessment may be sufficient to evaluate diuretic response and guide dose adjustments in AHF.
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Research ethics: The local Institutional Review Board deemed the study exempt from review (UA-02-23083).
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Informed consent: Informed consent was obtained from all individuals included in this study, or their legal guardians or wards.
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Author contributions: MYA and RNDA were involved in concepting and planning the research. RNDA, WPN, and DMN performed the data acquisition/collection. RNDA, WPN, and DMN calculated the experimental data and performed the analysis. RNDA, MYA and YA drafted the manuscript and designed the figures. MYA, HS, CP, LFKW, and IM aided in interpreting the results. All authors took parts in giving critical revision of the manuscript.
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Use of Large Language Models, AI and Machine Learning Tools: None declared.
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Conflict of interest: All other authors state no conflict of interest.
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Research funding: None declared.
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Data availability: All data generated or analyzed during this study were included in this published article. The corresponding author (M.Y.A.) can be contacted for more information.
References
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Articles in the same Issue
- Frontmatter
- Minireview
- Mental toughness and athletic performance: a narrative review
- Reviews
- The role of the urinary microbiome in diabetes-associated UTIs: current understanding and future directions
- Interleukin-23 (IL-23) inhibitor, mirikizumab in the treatment of ulcerative colitis (UC): a promising therapy?
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- Menopause, estrogen, and GERD: an exploration of symptoms and endoscopic correlations
- A study of pulmonary function in hypothyroid female patients of reproductive age group and its correlation with free T3, T4 and TSH
- A retrospective observational study to evaluate the association between self-reported binge alcohol drinkers and asthma
- Two hours of urine output are a reliable parameter for intravenous furosemide adequacy and the need for doubling dose in acute heart failure: a prospective study
- Physiological belching during impedance-pH monitoring: a meal with Coca-Cola provokes a prompt gastroesophageal reaction with increased prandial belching
