Home Medicine The underlying causes, treatment options of gut microbiota and food habits in type 2 diabetes mellitus: a narrative review
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The underlying causes, treatment options of gut microbiota and food habits in type 2 diabetes mellitus: a narrative review

  • Krishnendu Adhikary ORCID logo , Riya Sarkar , Sriparna Maity , Ipsita Banerjee , Prity Chatterjee , Koushik Bhattacharya ORCID logo , Deepika Ahuja , Nirmalya Kumar Sinha and Rajkumar Maiti ORCID logo EMAIL logo
Published/Copyright: May 16, 2024
Journal of Basic and Clinical Physiology and Pharmacology
From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 35 Issue 3

Abstract

Type 2 diabetes mellitus is a long-lasting endocrine disorder characterized by persistent hyperglycaemia, which is often triggered by an entire or relative inadequacy of insulin production or insulin resistance. As a result of resistance to insulin (IR) and an overall lack of insulin in the body, type 2 diabetes mellitus (T2DM) is a metabolic illness that is characterized by hyperglycaemia. Notably, the occurrence of vascular complications of diabetes and the advancement of IR in T2DM are accompanied by dysbiosis of the gut microbiota. Due to the difficulties in managing the disease and the dangers of multiple accompanying complications, diabetes is a chronic, progressive immune-mediated condition that plays a significant clinical and health burden on patients. The frequency and incidence of diabetes among young people have been rising worldwide. The relationship between the gut microbiota composition and the physio-pathological characteristics of T2DM proposes a novel way to monitor the condition and enhance the effectiveness of therapies. Our knowledge of the microbiota of the gut and how it affects health and illness has changed over the last 20 years. Species of the genus Eubacterium, which make up a significant portion of the core animal gut microbiome, are some of the recently discovered ‘generation’ of possibly helpful bacteria. In this article, we have focused on pathogenesis and therapeutic approaches towards T2DM, with a special reference to gut bacteria from ancient times to the present day.

Keywords: type 2 diabetes mellitus; chronic neuropathy; glucose transporter; modified insulin; gut bacteria
Corresponding author: Dr. Rajkumar Maiti, Assistant Professor & Head, Department of Physiology, Bankura Christian College, Bankura, West Bengal, 722101, India, E-mail:

Acknowledgments

The Principal of Bankura Christian College and Director, Paramedical College Durgapur is to be thanked by the authors for their unwavering inspiration and spiritual support of the review work.

  1. Research ethics: Not applicable.

  2. Informed consent: Not required.

  3. Author contributions: KA, RS, and SM: Conceptualization, data curation, writing, and original draft preparation. RM: Methodology, data curation, writing (original draft preparation), reviewing, and editing. IB, PC, KB, DA and NKS: Conceptualization, validation, writing, reviewing, and editing.

  4. Competing interests: The authors declare that they have no conflict of interest in the present review work. The manuscript has not been submitted for publication in another journal.

  5. Research funding: The current review was conducted without support from any extramural sources.

  6. Data availability: Not required.

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Received: 2024-03-23
Accepted: 2024-05-01
Published Online: 2024-05-16

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Editorials
  3. Doctor patient relationship in AI era: trying to decipher the problem
  4. “Adiponcosis interplay: adipose tissue, microenvironment and prostate cancer”
  5. Minireview
  6. Interplay between male gonadal function and overall male health
  7. Reviews
  8. How should we differentiate hypoglycaemia in non-diabetic patients?
  9. Pozelimab, a human monoclonal immunoglobulin for the treatment of CHAPLE disease
  10. Cannabis effectiveness on immunologic potency of pulmonary contagion
  11. Exploring the impact of vitamin D on tendon health: a comprehensive review
  12. The underlying causes, treatment options of gut microbiota and food habits in type 2 diabetes mellitus: a narrative review
  13. Original Articles
  14. Long-term functional outcomes and predictors of efficacy in thulium laser enucleation of the prostate (ThuLEP) for benign prostatic hyperplasia (BPH): a retrospective observational study
  15. Investigating Majhool date (Phoenix dactylifera) consumption effects on fasting blood glucose in animals and humans
  16. A novel variant in the FLNB gene associated with spondylocarpotarsal synostosis syndrome
  17. Exploring pathogenic pathways in carpal tunnel syndrome: sterile inflammation and oxidative stress
https://doi.org/10.1515/jbcpp-2024-0043
Keywords for this article
type 2 diabetes mellitus; chronic neuropathy; glucose transporter; modified insulin; gut bacteria

Articles in the same Issue

  1. Frontmatter
  2. Editorials
  3. Doctor patient relationship in AI era: trying to decipher the problem
  4. “Adiponcosis interplay: adipose tissue, microenvironment and prostate cancer”
  5. Minireview
  6. Interplay between male gonadal function and overall male health
  7. Reviews
  8. How should we differentiate hypoglycaemia in non-diabetic patients?
  9. Pozelimab, a human monoclonal immunoglobulin for the treatment of CHAPLE disease
  10. Cannabis effectiveness on immunologic potency of pulmonary contagion
  11. Exploring the impact of vitamin D on tendon health: a comprehensive review
  12. The underlying causes, treatment options of gut microbiota and food habits in type 2 diabetes mellitus: a narrative review
  13. Original Articles
  14. Long-term functional outcomes and predictors of efficacy in thulium laser enucleation of the prostate (ThuLEP) for benign prostatic hyperplasia (BPH): a retrospective observational study
  15. Investigating Majhool date (Phoenix dactylifera) consumption effects on fasting blood glucose in animals and humans
  16. A novel variant in the FLNB gene associated with spondylocarpotarsal synostosis syndrome
  17. Exploring pathogenic pathways in carpal tunnel syndrome: sterile inflammation and oxidative stress
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