Home Medicine Cannabis effectiveness on immunologic potency of pulmonary contagion
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Cannabis effectiveness on immunologic potency of pulmonary contagion

  • Sumana Das , Arya Ghosh , Varnita Karmakar , Sourav Khawas , Piyush Vatsha , Kishor Kumar Roy and Padma Charan Behera ORCID logo EMAIL logo
Published/Copyright: April 19, 2024
Journal of Basic and Clinical Physiology and Pharmacology
From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 35 Issue 3

Abstract

Respiratory illnesses and its repercussions are becoming more prevalent worldwide. It is necessary to research both innovative treatment and preventative techniques. Millions of confirmed cases and fatalities from the COVID-19 epidemic occurred over the previous two years. According to the review research, cannabinoids are a class of medicines that should be considered for the treatment of respiratory conditions. Cannabinoids and inhibitors of endocannabinoid degradation have illustrated advantageous anti-inflammatory, asthma, pulmonary fibrosis, and pulmonary artery hypotension in numerous studies (in vitro and in vivo). It has been also noted that CB2 receptors on macrophages and T-helper cells may be particularly triggered to lower inflammation in COVID-19 patients. Since the majority of lung tissue contains cannabinoid receptors, cannabis can be an effective medical tool for treating COVID-19 as well as pulmonary infections. Notably, CB2 and CB1 receptors play a major role in immune system modulation and anti-inflammatory activities. In this review, we put forth the idea that cannabis might be helpful in treating pulmonary contagion brought on by viral integration, such as that caused by SARS-CoV-2, haemophilus influenza type b, Streptococcus pneumoniae, influenza virus, and respiratory syncytial virus. Also, a detailed overview of CB receptors, intricate mechanisms, is highlighted connecting link with COVID-19 viral structural modifications along with molecular basis of CB receptors in diminishing viral load in pulmonary disorders supported through evident literature studies. Further, futuristic evaluations on cannabis potency through novel formulation development focusing on in vivo/in vitro systems can produce promising results.

Keywords: pulmonary infection; cannabis; cannabinoids; COVID-19; SARS CoV-2
Corresponding author: Padma Charan Behera, Department of Pharmaceutical Sciences, Bengal College of Pharmaceutical Technology, MAKAUT university, Dubrajpur, Birbhum 731123, India, E-mail:

Acknowledgments

Thank you to the department of pharmaceutical sciences and technology (BIT, mesra), my advisor Dr. Padma charan bahera sir and all of coauthors who have supported me.

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: Arya Ghosh, Varnita Karmakar.

  4. Competing interests: The authors state no conflict of interest.

  5. Research funding: None declared.

  6. Data availability: Not applicable.

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Received: 2023-02-06
Accepted: 2024-02-17
Published Online: 2024-04-19

© 2024 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jbcpp-2023-0030
Keywords for this article
pulmonary infection; cannabis; cannabinoids; COVID-19; SARS CoV-2

Articles in the same Issue

  1. Frontmatter
  2. Editorials
  3. Doctor patient relationship in AI era: trying to decipher the problem
  4. “Adiponcosis interplay: adipose tissue, microenvironment and prostate cancer”
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