Efficacy of Habb-e-Asab in diabetic peripheral neuropathy: a randomized placebo control study

Fathima Nafha Nizamdeen; Mohd Aleemuddin Quamri; Md Anzar Alam

doi:10.1515/jbcpp-2021-0330

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Efficacy of Habb-e-Asab in diabetic peripheral neuropathy: a randomized placebo control study

Fathima Nafha Nizamdeen , Mohd Aleemuddin Quamri und Md Anzar Alam

Veröffentlicht/Copyright: 14. Januar 2022

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Aus der Zeitschrift Journal of Basic and Clinical Physiology and Pharmacology Band 34 Heft 6

Abstract

Objectives

Diabetic peripheral neuropathy (DPN) is a common diabetes complication. The prevalence of neuropathy is 55% for type 1 and 66% for type 2 diabetes. In Unani medicine neuropathy is known as Khidr (numbness). It is treated with drugs possessing hypoglycemic and analgesic properties, etc. Habb-e-Asab, a polyherbal Unani formulation used for the treatment of Waja-ul-Asab (neuralgia) is routinely used for its indications in neurological pain in Unani medicine. The aim of this study to investigate the efficacy of Habb-e-Asab in diabetic peripheral neuropathy.

Methods

Thirty patients with DPN were randomly assigned to test (n=20) and control (n=10) groups in a randomized single-blind placebo control study. For 45 days, the test group was given 250 mg Habb-e-Asab twice a day and the control group 250 mg placebo twice a day. The subjective parameters Pain in feet, burning in feet, and tingling in feet was assessed by the arbitrary scale and VAS fortnightly and objective parameters MNSI, and VPT was assessed in pre–post-treatment.

Results

The research drug revealed highly statistically significant with p<0.001 on VAS score and MNSI whereas VPT is significant with p<0.01 on few points. But control group exhibits no significant effect in any of the parameters. No adverse effects had been reported in either group.

Conclusions

Our finding indicated that the Habb-e-Asab for 45 days improved and reduced the severity of DPN in a patient with diabetes (CTRI/2018/02/011725).

Keywords: diabetic peripheral neuropathy; Habb-e-Asab ; Khidr ; neuralgia; Waja-ul-Asab

Corresponding author: Mohd Aleemuddin Quamri, Department of Moalajat, National Institute of Unani Medicine, Kottigepalya, Magadi Main Road, Bangalore 560091, India, Phone: +91 7019383563, E-mail: drmaquamri@gmail.com

Acknowledgments

This study was a partial fulfillment of the MD dissertation which was supported by the National Institute of Unani Medicine (NIUM), Bangalore (Ministry of AYUSH Government of India). Work duly acknowledges our colleagues for their valuable suggestions and support throughout the study and especially to the human subjects who were recruited for the study. I am also thanks to Dr. K.P. Suresh, Scientist (Biostatistics), National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bangalore, for data analysis.

Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: The protocol was approved by the Institutional Ethical Committee of NIUM, IEC No. NIUM /IEC/201 6-17/008/Moal/08, Dated.18.05.2017.

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Received: 2021-11-15

Accepted: 2021-12-20

Published Online: 2022-01-14

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Artikel in diesem Heft

https://doi.org/10.1515/jbcpp-2021-0330

Schlagwörter für diesen Artikel

diabetic peripheral neuropathy; Habb-e-Asab; Khidr; neuralgia; Waja-ul-Asab