Drug utilization study and cost analysis of adult β-thalassemia major patient therapy at Dr. Soetomo General Hospital Surabaya
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Hasna Qatrunnada
,
Siprianus Ugroseno Yudho Bintoro
Abstract
Objectives
The main therapy of β-thalassemia major are blood transfusion and iron chelation drugs. However, those therapies also have some adverse effects and problems such as iron overload, transfusion reactions, nutritional deficiencies, and patient compliance problems. Those arising problems also have an impact on therapy cost. Hence, this study was designed to analyze drug utilization study and cost of therapy in β-thalassemia major adult patients at Dr. Soetomo General Hospital Surabaya.
Methods
This research was conducted in descriptive observational-retrospective design using secondary data obtained from patient’s medical records and billing registrations from January 1–December 31, 2019.
Results
There were 18 patients out of 233 patients that were analyzed. Deferasirox was the most administered drug with doses between 500 mg/day–1,500 mg/day while deferiprone was ranged between 1,500 and 4,500 mg/day. Patients also received transfusion reaction drugs with dexamethasone injection 5 mg/ml which was administered the most. The most administered supplement was folic acid 1 mg. Patients had an increase in serum ferritin due to low compliance. Deferasirox had the most adherence number of patients with decrease of serum ferritin. The two highest costs of direct medical components were top-up medicines and consumable medical supplies. Overall, the hospital gained profit from national health insurance claims.
Conclusions
The most administered chelating agent was deferasirox. Deferasirox also had the most adherence number of patients with decreased number of serum ferritin. However, deferasirox also yielded the highest cost. Yet, overall, the hospital gained profit from national health insurance claims.
Funding source: Tahir Professorship
Award Identifier / Grant number: 250 USD
Acknowledgments
Gratitude is due to the Director of Dr. Soetomo General Hospital, Head of Department Internal Medicine and Head of Pharmacy Installation Dr. Soetomo General Hospital, and also Tahir Professorship.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Not applicable.
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Ethical approval: Research involving nonhuman subjects complied with all relevant national regulations, institutional policies and has been approved by the authors’ institutional review board (Ethical committee of Dr. Soetomo General Hospital, 1853/KEPK/III/2020).
References
1. National Heart, Lung, and Blood Institute Your guide to anemia, vol 11. U.S. USA: NH Publication; 2011:6p.Suche in Google Scholar
2. Cappellini, MD, Cohen, A, Porter, J, Taher, A, Viprakasit, V. Guidelines for the management of transfusion dependent thalassaemia (tdt), 3rd ed. Nicosia city: TIF Publication; 2014, vol 20:17–52 pp.Suche in Google Scholar
3. Ineck, B, Mason, BJ, Lyons, W. Anemias. In: Joseph, TD, Robert, LT, Gary, CY, Cary, RM, Barbara, GW, Michael, P, editors. Pharmacotherapy a pathophysiologic approach, 7th ed. New York: The McGraw-Hill Companies Inc.; 2016:1639–63 pp.Suche in Google Scholar
4. Indonesian Health Ministry. Angka pembawa sifat talasemia tergolong tinggi. Available from: https://www.depkes.go.id/article/view/19052100003/angka-pembawa-sifat-talasemia-tergolong-tinggi.html [Accessed 10 Nov 2019].Suche in Google Scholar
5. Joint Formulary Committee. British national formulary, 78th ed. London: BMJ Group and Pharmaceutical Press; 2019:1026–8 pp.Suche in Google Scholar
6. Castillo, B, Dasgupta, A, Klein, K, Tint, H, Wahed, A, editors. Transfusion medicine for pathologists: a comprehensive review for board preparation, certification, and clinical practice. New York: Elsevier; 2018:37–49 pp.10.1016/B978-0-12-814313-1.00003-4Suche in Google Scholar
7. Sarai, M, Tejani, AM. Loop diuretics for patients receiving blood transfusions. Cochrane Database Syst Rev 2015;2:2–13. https://doi.org/10.1002/14651858.CD010138.pub2.Suche in Google Scholar PubMed PubMed Central
8. Geiger, TL, Howard, SC. Acetaminophen and diphenhydramine premedication for allergic and febrile non-hemolytic transfusion reactions: good prophylaxis or bad practice. Transfus Med Rev 2007;21:1–12. https://doi.org/10.1016/j.tmrv.2006.09.001.Suche in Google Scholar PubMed PubMed Central
9. Decree of Indonesian Health Ministry Number HK.01.07/Menkes/1/2018. Pedoman nasional pelayanan tata laksana thalasemia. Jakarta: Indonesian Health Ministry; 2018.Suche in Google Scholar
10. Goldberg, EK, Neogi, S, Lal, A, Higa, A, Fung, E. Nutritional deficiencies are common in patients with transfusion-dependent thalassemia and associated with iron overload. J Food Nutr Res 2018;6:674–81.10.12691/jfnr-6-10-9Suche in Google Scholar PubMed PubMed Central
11. Porter, JB, Evangeli, M, El-Beshlawy, A. The challenges of adherence and persistence with iron chelation therapy. Int J Hematol 2011;94:453–60. https://doi.org/10.1007/s12185-011-0927-3.Suche in Google Scholar PubMed
12. Hossain, MS, Enayetur, R, Tanvira, AS, Shameema, F, Nusrat, N, Sazia, I, et al.. Thalassemias in South Asia: clinical lessons learnt from Bangladesh. OJRD 2017;93:1–2. https://doi.org/10.1186/s13023-017-0643-z.Suche in Google Scholar PubMed PubMed Central
13. Indonesian Health Ministry. Talasemia, penyakit berbiaya tinggi ke-5 di indonesia. Available from: https://www.depkes.go.id/article/view/19052100001/-talasemia-penyakit-berbiaya-tinggi-ke-5-di-indonesia.html [Accessed 11 Nov 2019].Suche in Google Scholar
14. Regulation of Indonesian Health Ministry Number 76 Indonesian Case Base Groups (INA-CBG) Guidance Dalam Pelaksanaan Jaminan Kesehatan Nasional. Jakarta: Indonesian Health Ministry; 2016.Suche in Google Scholar
15. National Organization for rare disorders. Beta thalassemia. Available from: https://rarediseases.org/rare-diseases/thalassemia-major/ [Accessed 4 Aug 2020].Suche in Google Scholar
16. Al-ali, ZAJR, Faraj, SH. Prevalence of β-thalassemia patients in Missan province. GJBAHS 2016;5:68–70.Suche in Google Scholar
17. Dhanya, R, Sedai, A, Ankita, K, Parmar, L, Agarwal, RK, Hegde, S, et al.. Life expectancy and risk factors for early death in patients with severe thalassemia syndromes in south india. Blood Adv 2019;4:1448–56.Suche in Google Scholar
18. Sheth, S. Iron chelation: an update. Curr Opin Hematol 2014;21:1–7. https://doi.org/10.1097/moh.0000000000000031.Suche in Google Scholar
19. Pepe, A, Meloni, A, Capra, M, Cianciulli, P, Prossomariti, L, Malaventura, C, et al.. Deferasirox, deferiprone, and deferrioxamine treatment in thalassemia major patients: cardiac iron and fuction comparison determined by quantitative magnetic resonance imaging. Haematology 2011;96:41–7. https://doi.org/10.3324/haematol.2009.019042.Suche in Google Scholar PubMed PubMed Central
20. Torres, R, Kenney, B, Tormey, CA. Diagnosis, treatment, and reporting of adverse effects of transfusion. Lab Med 2012;43:217–30. https://doi.org/10.1309/lm3naabjjk1hnyfu.Suche in Google Scholar
21. Gardner, K, Hoppe, C, Mijovic, A, Thein, SL. How we treat delayed haemolytic transfusion reactions in patients with sickle cell disease. Br J Haematol 2015 May 13. https://doi.org/10.1111/bjh.13494 [Epub ahead of print].Suche in Google Scholar PubMed
22. Mahmood, L. The metabolic processes of folic acid and vitamin B12 deficiency. J Health Res Rev 2014;1:5–9. https://doi.org/10.4103/2394-2010.143318.Suche in Google Scholar
23. Koury, MJ, Ponka, P. New insights into erythropoiesis: the roles of folate, vitamin B12, and iron. Annu Rev Nutr 2004;24:105–31. https://doi.org/10.1146/annurev.nutr.24.012003.132306.Suche in Google Scholar PubMed
24. Borgna-pignatti, C, Gamberini, MR. Complications of thalassemia major and their treatment. Expert Rev Hematol 2011;3:353–5. https://doi.org/10.1586/ehm.11.29.Suche in Google Scholar PubMed
25. Regulation of Indonesian Health Ministry Number 64 Perubahan Atas Peraturan Menteri Kesehatan Nomor 52 Tahun 2016 Tentang Standar Tarif Pelayanan Kesehatan Dalam Penyelenggaraan Program Jaminan Kesehatan. Jakarta: Indonesian Health Ministry; 2016.Suche in Google Scholar
© 2021 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Original Articles
- Cost of illness of diabetes mellitus in Indonesia: a systematic review
- Social media health interventions to improve diabetes mellitus patient outcome: a systematic review
- Developing pharmacokinetics–pharmacodynamics model of valproic acid syrup based on prediction of population pharmacokinetics parameter and seizure frequency in Indonesian pediatric epilepsy outpatients
- Acetylcholinesterase inhibitory activity of extract and fractions from the root of Rauvolfia serpentina(L.) Bth.ex Kurz
- Green tea and its active compound epigallocathechin-3-gallate (EGCG) inhibit neuronal apoptosis in a middle cerebral artery occlusion (MCAO) model
- The effects of quercetin on nicotine-induced reward effects in mice
- Resveratrol ameliorates physical and psychological stress-induced depressive-like behavior
- Translation and cross-cultural adaption of an instrument measuring patient’s well-being under treatment for schizophrenia
- Quercetin promotes behavioral recovery and biomolecular changes of melanocortin-4 receptor in mice with ischemic stroke
- Knowledge and attitudes of healthcare professionals on prescribing errors
- Inhibition of Ras and STAT3 activity of 4-(tert-butyl)-N-carbamoylbenzamide as antiproliferative agent in HER2-expressing breast cancer cells
- Predicting the molecular mechanism of glucosamine in accelerating bone defect repair by stimulating osteogenic proteins
- Larvicidal toxicity and parasporal inclusion of native Bacillus thuringiensis BK5.2 against Aedes aegypti
- Synthesis, ADMET predictions, molecular docking studies, and in-vitro anticancer activity of some benzoxazines against A549 human lung cancer cells
- Thymoquinone and its derivatives against breast cancer with HER2 positive: in silico studies of ADMET, docking and QSPR
- Assessment of patient understanding of their conventional cardiac medicines and herbal prepared/derived products: preliminary survey and interviews with selected community-dwelling elderly patients in the Philippines
- The development and validation of the health belief model questionnaire for measuring factors affecting adherence in the elderly with hypertension
- Analysis of the side effect of QTc interval prolongation in the bedaquiline regimen in drug resistant tuberculosis patients
- Shallot skin profilling, computational evaluation of physicochemical properties, ADMET, and molecular docking of its components against P2Y12 receptor
- Analysis of HMGB-1 level before and after providing atorvastatin standard therapy in coronary artery disease patients with type-2 diabetes mellitus compared to without type-2 diabetes mellitus
- Analysis of matrix metalloproteinase-9 levels among acute heart failure patients with ACE inhibitor therapy (Dr. Soetomo Regional General Hospital, Surabaya)
- The correlation between self-related adherence, asthma-related quality of life and control of asthma in adult patients
- Providing counseling through home pharmacy care (HPC) for hemodialysis patients with hypertension in lowering blood pressure
- Community knowledge and attitude in recognizing asthma symptoms and using medication for asthma attacks: a cross-sectional study
- A study of anticoagulant therapy in patients with coronary artery disease
- The association of FKBP5 polymorphism with asthma susceptibility in asthmatic patients
- Gastroprotective effect of fluvoxamine and ondansetron on stress-induced gastric ulcers in mice
- Osteoblast iron genes: real time PCR and microarray hybridization approach under hyperoxia
- Attenuation of hyperplasia in lung parenchymal and colonic epithelial cells in DMBA-induced cancer by administering Andrographis paniculata Nees extract using animal model
- N-nitrosodiethylamine induces inflammation of liver in mice
- AST/ALT levels, MDA, and liver histopathology of Echinometra mathaei ethanol extract on paracetamol-induced hepatotoxicity in rats
- Development, characterization, molecular docking, and in vivo skin penetration of coenzyme Q10 nanostructured lipid carriers using tristearin and stearyl alcohol for dermal delivery
- The effect of Camellia sinensis (green tea) with its active compound EGCG on neuronal cell necroptosis in Rattus norvegicus middle cerebral artery occlusion (MCAO) model
- Hepatoprotective effect of ethanolic extract of sugarcane (Saccharum officinarum Linn.) leaves
- Correlation between the exposure time to mobile devices and the prevalence of evaporative dry eyes as one of the symptoms of computer vision syndrome among Senior High School students in East Java, Indonesia
- The effect of various high-fat diet on liver histology in the development of NAFLD models in mice
- Fabrication and characterization of bovine hydroxyapatite-gelatin-alendronate scaffold cross-linked by glutaraldehyde for bone regeneration
- Health related quality of life among postmenopausal woman with hormone responsive HER2− breast cancer in Indonesia
- Gender differences in the blood glucose type 2 diabetes patients with combination rapid and long acting insulin therapy
- Correlation of dietary iron intake and serum iron with thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels in adult hyperthyroid patients
- The effect of pillbox use and education by pharmacist toward medication adherence in diabetes mellitus patients in a Primary Health Care Center in Mataram
- Variation concentration effect of propyleneglycol, glycerin, and polyethyleneglycol 400 to physical properties and dissolution rate of loratadine liquisolid tablet
- Role of Centella asiatica and ceramide in skin barrier improvement: a double blind clinical trial of Indonesian batik workers
- Secondary metabolite and antipyretic effects of Maja (Crescentia cujete L.) in fever-induced mice
- Hydration effect on kidney function and serum electrolyte in children with tumor lysis syndrome (TLS) and risk of TLS
- Drug utilization study and cost analysis of adult β-thalassemia major patient therapy at Dr. Soetomo General Hospital Surabaya
- The role of hyperbaric oxygen to platelet aggregation in noninsulin-dependent diabetes mellitus (NIDDM)
- Cocrystal formation of loratadine-succinic acid and its improved solubility
- The role of chondroitin sulfate to bone healing indicators and compressive strength
- The effects of quercetin on the expression of SREBP-1c mRNA in high-fat diet-induced NAFLD in mice
- Analysis of stress ulcer prophylaxis drug regimentation in surgical patients
- The stability and irritability study of the chitosan–Aloe vera spray gel as wound healing
- Effectiveness of citicoline in pediatric patients with refractive amblyopia in Surabaya, East Java, Indonesia
- The thermodynamic study of p-methoxycinnamic acid inclusion complex formation, using β-cyclodextrin and hydroxypropyl-β-cyclodextrin
- The effect of chitosan type and drug-chitosan ratio on physical characteristics and release profile of ketoprofen microparticles prepared by spray drying
- The maximum dose and duration in the therapy single use methotrexate to achieve remission by rheumatoid arthritis patients through disease activity score 28 (DAS28)
- Knowledge, attitudes, and practices (KAP) towards COVID-19 among university students in Pakistan: a cross-sectional study
- The impact of glutaraldehyde on the characteristics of bovine hydroxyapatite-gelatin based bone scaffold as gentamicin delivery system
- Analysis of the use of antibiotics profile and factors of surgical site infections study on digestive and oncology surgeries
- Second internal transcribed spacer (ITS-2) as genetic marker for molecular characterization of Sarcoptes scabiei in rabbits from several areas of East Java, Indonesia
- Design of gossypetin derivatives based on naturally occurring flavonoid in Hibiscus sabdariffa and the molecular docking as antibacterial agents
- Discovery of new targeting agents against GAPDH receptor for antituberculosis drug delivery
- The effect of red passion fruit (Passiflora edulis Sims.) fermentation time on its activity against Extended Strain Methicillin-Resistant (ESBL) Escherichia coli and Methicillin-Resistant Staphylococcus aureus (MRSA)
- Antibiotic use on acute respiratory tract infection nonpneumonia and nonspecific diarrhea in Primary Health Care Centre in Banjarbaru City, South Kalimantan, Indonesia
- Screening of anti-HIV activities in ethanol extract and fractions from Ficus fistulosa leaves
- The characteristics of lactic acid bacteria isolated from fermented food as potential probiotics
- Profile of gyrA gene mutation in clinical isolate of levofloxacin resistant Escherichia coli
- Antimicrobial activity of Centella asiatica and Gigantochloa apus
- Drug-related problems of antibiotic use in gastroenteritis related to patient therapy outcomes at Universitas Gadjah Mada Hospital
- The impact of suitability of empirical antibiotics use on therapeutic outcome of respiratory tract infection patients at inpatient wards of Universitas Gadjah Mada Academic Hospital
- Genetic profile mutation rpoB in clinical isolate of rifampicin-resistant Staphylococcus aureus
- Hematological side effect analysis of linezolid in MDR-TB patients with individual therapy
- Adverse drug reaction and its management in tuberculosis patients with multidrug resistance: a retrospective study
- Analysis of prophylactic antibiotic use and risk factor of postoperative infection in urological surgery patients
- Molecular docking studies of Nigella sativa L and Curcuma xanthorrhiza Roxb secondary metabolites against histamine N-methyltransferase with their ADMET prediction
- Prediction of compounds with antiosteoporosis activity in Chrysophyllum cainito L. leaves through in silico approach
- Phyllanthin and hypophyllanthin, the isolated compounds of Phyllanthus niruri inhibit protein receptor of corona virus (COVID-19) through in silico approach
- Cratoxylum sumatranum stem bark exhibited antimalarial activity by Lactate Dehydrogenase (LDH) assay
- Endophytic fungi inhabiting Physalis angulata L. plant: diversity, antioxidant, and antibacterial activities of their ethyl acetate extracts
- Exploration of several plants from Baung Forest on bone formation cell models
- In vitro antimalarial activity of Garcinia parvifolia Miq. Stem extracts and fractions on Plasmodium falciparum lactate dehydrogenase (LDH) assay
- Antioxidant and antiviral potency of Begonia medicinalis fractions
- Artocarpus sericicarpus stem bark contains antimalarial substances against Plasmodium falciparum
- Formulation and characterization of Eleutherine palmifolia extract-loaded self-nanoemulsifying drug delivery system (SNEDDS)
- Analytical method for the determination of curcumin entrapped in polymeric micellar powder using HPLC
- Challenges in the provision of natural medicines by community pharmacists in East Java Province, Indonesia
- In vitro and in silico analysis of phytochemical compounds of 96% ethanol extract of semanggi (Marsilea crenata Presl.) leaves as a bone formation agent
- Inhibitory activity of Urena lobata leaf extract on alpha-amylase and alpha-glucosidase: in vitro and in silico approach
- Case Report
- Effect of hydrocortisone on hypocorticolism caused by pituitary adenoma
Artikel in diesem Heft
- Frontmatter
- Original Articles
- Cost of illness of diabetes mellitus in Indonesia: a systematic review
- Social media health interventions to improve diabetes mellitus patient outcome: a systematic review
- Developing pharmacokinetics–pharmacodynamics model of valproic acid syrup based on prediction of population pharmacokinetics parameter and seizure frequency in Indonesian pediatric epilepsy outpatients
- Acetylcholinesterase inhibitory activity of extract and fractions from the root of Rauvolfia serpentina(L.) Bth.ex Kurz
- Green tea and its active compound epigallocathechin-3-gallate (EGCG) inhibit neuronal apoptosis in a middle cerebral artery occlusion (MCAO) model
- The effects of quercetin on nicotine-induced reward effects in mice
- Resveratrol ameliorates physical and psychological stress-induced depressive-like behavior
- Translation and cross-cultural adaption of an instrument measuring patient’s well-being under treatment for schizophrenia
- Quercetin promotes behavioral recovery and biomolecular changes of melanocortin-4 receptor in mice with ischemic stroke
- Knowledge and attitudes of healthcare professionals on prescribing errors
- Inhibition of Ras and STAT3 activity of 4-(tert-butyl)-N-carbamoylbenzamide as antiproliferative agent in HER2-expressing breast cancer cells
- Predicting the molecular mechanism of glucosamine in accelerating bone defect repair by stimulating osteogenic proteins
- Larvicidal toxicity and parasporal inclusion of native Bacillus thuringiensis BK5.2 against Aedes aegypti
- Synthesis, ADMET predictions, molecular docking studies, and in-vitro anticancer activity of some benzoxazines against A549 human lung cancer cells
- Thymoquinone and its derivatives against breast cancer with HER2 positive: in silico studies of ADMET, docking and QSPR
- Assessment of patient understanding of their conventional cardiac medicines and herbal prepared/derived products: preliminary survey and interviews with selected community-dwelling elderly patients in the Philippines
- The development and validation of the health belief model questionnaire for measuring factors affecting adherence in the elderly with hypertension
- Analysis of the side effect of QTc interval prolongation in the bedaquiline regimen in drug resistant tuberculosis patients
- Shallot skin profilling, computational evaluation of physicochemical properties, ADMET, and molecular docking of its components against P2Y12 receptor
- Analysis of HMGB-1 level before and after providing atorvastatin standard therapy in coronary artery disease patients with type-2 diabetes mellitus compared to without type-2 diabetes mellitus
- Analysis of matrix metalloproteinase-9 levels among acute heart failure patients with ACE inhibitor therapy (Dr. Soetomo Regional General Hospital, Surabaya)
- The correlation between self-related adherence, asthma-related quality of life and control of asthma in adult patients
- Providing counseling through home pharmacy care (HPC) for hemodialysis patients with hypertension in lowering blood pressure
- Community knowledge and attitude in recognizing asthma symptoms and using medication for asthma attacks: a cross-sectional study
- A study of anticoagulant therapy in patients with coronary artery disease
- The association of FKBP5 polymorphism with asthma susceptibility in asthmatic patients
- Gastroprotective effect of fluvoxamine and ondansetron on stress-induced gastric ulcers in mice
- Osteoblast iron genes: real time PCR and microarray hybridization approach under hyperoxia
- Attenuation of hyperplasia in lung parenchymal and colonic epithelial cells in DMBA-induced cancer by administering Andrographis paniculata Nees extract using animal model
- N-nitrosodiethylamine induces inflammation of liver in mice
- AST/ALT levels, MDA, and liver histopathology of Echinometra mathaei ethanol extract on paracetamol-induced hepatotoxicity in rats
- Development, characterization, molecular docking, and in vivo skin penetration of coenzyme Q10 nanostructured lipid carriers using tristearin and stearyl alcohol for dermal delivery
- The effect of Camellia sinensis (green tea) with its active compound EGCG on neuronal cell necroptosis in Rattus norvegicus middle cerebral artery occlusion (MCAO) model
- Hepatoprotective effect of ethanolic extract of sugarcane (Saccharum officinarum Linn.) leaves
- Correlation between the exposure time to mobile devices and the prevalence of evaporative dry eyes as one of the symptoms of computer vision syndrome among Senior High School students in East Java, Indonesia
- The effect of various high-fat diet on liver histology in the development of NAFLD models in mice
- Fabrication and characterization of bovine hydroxyapatite-gelatin-alendronate scaffold cross-linked by glutaraldehyde for bone regeneration
- Health related quality of life among postmenopausal woman with hormone responsive HER2− breast cancer in Indonesia
- Gender differences in the blood glucose type 2 diabetes patients with combination rapid and long acting insulin therapy
- Correlation of dietary iron intake and serum iron with thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels in adult hyperthyroid patients
- The effect of pillbox use and education by pharmacist toward medication adherence in diabetes mellitus patients in a Primary Health Care Center in Mataram
- Variation concentration effect of propyleneglycol, glycerin, and polyethyleneglycol 400 to physical properties and dissolution rate of loratadine liquisolid tablet
- Role of Centella asiatica and ceramide in skin barrier improvement: a double blind clinical trial of Indonesian batik workers
- Secondary metabolite and antipyretic effects of Maja (Crescentia cujete L.) in fever-induced mice
- Hydration effect on kidney function and serum electrolyte in children with tumor lysis syndrome (TLS) and risk of TLS
- Drug utilization study and cost analysis of adult β-thalassemia major patient therapy at Dr. Soetomo General Hospital Surabaya
- The role of hyperbaric oxygen to platelet aggregation in noninsulin-dependent diabetes mellitus (NIDDM)
- Cocrystal formation of loratadine-succinic acid and its improved solubility
- The role of chondroitin sulfate to bone healing indicators and compressive strength
- The effects of quercetin on the expression of SREBP-1c mRNA in high-fat diet-induced NAFLD in mice
- Analysis of stress ulcer prophylaxis drug regimentation in surgical patients
- The stability and irritability study of the chitosan–Aloe vera spray gel as wound healing
- Effectiveness of citicoline in pediatric patients with refractive amblyopia in Surabaya, East Java, Indonesia
- The thermodynamic study of p-methoxycinnamic acid inclusion complex formation, using β-cyclodextrin and hydroxypropyl-β-cyclodextrin
- The effect of chitosan type and drug-chitosan ratio on physical characteristics and release profile of ketoprofen microparticles prepared by spray drying
- The maximum dose and duration in the therapy single use methotrexate to achieve remission by rheumatoid arthritis patients through disease activity score 28 (DAS28)
- Knowledge, attitudes, and practices (KAP) towards COVID-19 among university students in Pakistan: a cross-sectional study
- The impact of glutaraldehyde on the characteristics of bovine hydroxyapatite-gelatin based bone scaffold as gentamicin delivery system
- Analysis of the use of antibiotics profile and factors of surgical site infections study on digestive and oncology surgeries
- Second internal transcribed spacer (ITS-2) as genetic marker for molecular characterization of Sarcoptes scabiei in rabbits from several areas of East Java, Indonesia
- Design of gossypetin derivatives based on naturally occurring flavonoid in Hibiscus sabdariffa and the molecular docking as antibacterial agents
- Discovery of new targeting agents against GAPDH receptor for antituberculosis drug delivery
- The effect of red passion fruit (Passiflora edulis Sims.) fermentation time on its activity against Extended Strain Methicillin-Resistant (ESBL) Escherichia coli and Methicillin-Resistant Staphylococcus aureus (MRSA)
- Antibiotic use on acute respiratory tract infection nonpneumonia and nonspecific diarrhea in Primary Health Care Centre in Banjarbaru City, South Kalimantan, Indonesia
- Screening of anti-HIV activities in ethanol extract and fractions from Ficus fistulosa leaves
- The characteristics of lactic acid bacteria isolated from fermented food as potential probiotics
- Profile of gyrA gene mutation in clinical isolate of levofloxacin resistant Escherichia coli
- Antimicrobial activity of Centella asiatica and Gigantochloa apus
- Drug-related problems of antibiotic use in gastroenteritis related to patient therapy outcomes at Universitas Gadjah Mada Hospital
- The impact of suitability of empirical antibiotics use on therapeutic outcome of respiratory tract infection patients at inpatient wards of Universitas Gadjah Mada Academic Hospital
- Genetic profile mutation rpoB in clinical isolate of rifampicin-resistant Staphylococcus aureus
- Hematological side effect analysis of linezolid in MDR-TB patients with individual therapy
- Adverse drug reaction and its management in tuberculosis patients with multidrug resistance: a retrospective study
- Analysis of prophylactic antibiotic use and risk factor of postoperative infection in urological surgery patients
- Molecular docking studies of Nigella sativa L and Curcuma xanthorrhiza Roxb secondary metabolites against histamine N-methyltransferase with their ADMET prediction
- Prediction of compounds with antiosteoporosis activity in Chrysophyllum cainito L. leaves through in silico approach
- Phyllanthin and hypophyllanthin, the isolated compounds of Phyllanthus niruri inhibit protein receptor of corona virus (COVID-19) through in silico approach
- Cratoxylum sumatranum stem bark exhibited antimalarial activity by Lactate Dehydrogenase (LDH) assay
- Endophytic fungi inhabiting Physalis angulata L. plant: diversity, antioxidant, and antibacterial activities of their ethyl acetate extracts
- Exploration of several plants from Baung Forest on bone formation cell models
- In vitro antimalarial activity of Garcinia parvifolia Miq. Stem extracts and fractions on Plasmodium falciparum lactate dehydrogenase (LDH) assay
- Antioxidant and antiviral potency of Begonia medicinalis fractions
- Artocarpus sericicarpus stem bark contains antimalarial substances against Plasmodium falciparum
- Formulation and characterization of Eleutherine palmifolia extract-loaded self-nanoemulsifying drug delivery system (SNEDDS)
- Analytical method for the determination of curcumin entrapped in polymeric micellar powder using HPLC
- Challenges in the provision of natural medicines by community pharmacists in East Java Province, Indonesia
- In vitro and in silico analysis of phytochemical compounds of 96% ethanol extract of semanggi (Marsilea crenata Presl.) leaves as a bone formation agent
- Inhibitory activity of Urena lobata leaf extract on alpha-amylase and alpha-glucosidase: in vitro and in silico approach
- Case Report
- Effect of hydrocortisone on hypocorticolism caused by pituitary adenoma
