Histomorphometric study on effects of monosodium glutamate in liver tissue of Wistar rats
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Anil Kumar Reddy
Abstract
Objectives
Thousands of food additives are being used by the food industries in ready to eat packed food. These food additives act as either preservatives or enhancers of palatability. Monosodium glutamate (MSG), a sodium salt of glutamic acid is a widely used food additive for enhancing taste. It gives the unique taste to the food called “Umami” or “Savory taste”, which is different from four primary tastes namely, sweet, sour, salty, and bitter. The current experimental study was investigated by dose-related effects of MSG on adult Wistar rats using histological and histomorphometric techniques.
Methods
Twenty-eight adult Wistar rats were divided into four groups i.e.; one control and three experimental groups. Rats were administered orally with different doses of MSG to the experimental groups and distilled water to the control groups consecutively for 45 days. At the end of the study, rats were sacrificed and tissues were collected for the examination.
Results
Histomorphometric data of the nuclei diameter of hepatocytes showed significant variation between control and experimental groups. Less PAS-positive material found in a higher dose of MSG-induced rats in histochemical observation.
Conclusions
One of the challenges of the problem of animal experimental studies is the application of results to human dietary intake of MSG. Based on the dose-dependent findings of the current study; it is evident that the administration of MSG is hepatotoxic in adult Wistar rats.
Acknowledgments
The authors gratefully acknowledge the statistical assistance provided by the staff working in Department of Community Medicine and generosity of various supporters.
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Research funding: This study was self-funded by the corresponding author.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Not applicable.
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Ethical approval: The Institutional Ethical Committee had given the approval with Ref No. ANIIMS/IEC/2017-18/082 for conducting the study.
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
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- Potential anti-toxic effect of d-ribose-l-cysteine supplement on the reproductive functions of male rats administered cyclophosphamide
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- Protective and curative role of vitamin D and hormones on the cadmium-induced inhibition of proliferation of human osteoblast cells
- The effect of bee pollen on reproductive and biochemical parameters in methotrexate-induced testicular damage in adult rats
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Artikel in diesem Heft
- Frontmatter
- Reviews
- N-acetyl-cysteine as adjuvant therapy in female infertility: a systematic review and meta-analysis
- Climate change and declining fertility rate in Malaysia: the possible connexions
- Original Articles
- Potential anti-toxic effect of d-ribose-l-cysteine supplement on the reproductive functions of male rats administered cyclophosphamide
- Environmental and climatic impact on the infection and mortality of SARS-CoV-2 in Peru
- Prophylactic intravenous paracetamol use in extremely premature infants for patent ductus arteriosus
- Evaluation of heart rate variability, blood pressure and lipid profile alterations from dual transceiver mobile phone radiation exposure
- Strain specific response of mice to IMQ-induced psoriasis
- Curcumin exerts hepatoprotection via overexpression of Paraoxonase-1 and its regulatory genes in rats undergone bile duct ligation
- Zinc oxide nanoparticles with green tea extract complex in the pancreas of rats against monosodium glutamate toxicity
- Phenolic constituents and inhibitory effects of the leaf of Rauvolfia vomitoria Afzel on free radicals, cholinergic and monoaminergic enzymes in rat’s brain in vitro
- Protective and curative role of vitamin D and hormones on the cadmium-induced inhibition of proliferation of human osteoblast cells
- The effect of bee pollen on reproductive and biochemical parameters in methotrexate-induced testicular damage in adult rats
- Histomorphometric study on effects of monosodium glutamate in liver tissue of Wistar rats
- Diligent profiling of preclinical safety of the silk protein sericin
