Aqueous extract of Adansonia digitata prevents Cadmium Chloride-induced testicular damage in Wistar Rats
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Babatunde Joseph Dare
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Oluwafemi Isaac Oyeniyi
Abstract
Objectives
The role of aqueous extract of Adansonia digitata was investigated against cadmium chloride-induced testicular damage in Wistar Rats.
Methods
Thirty (30) male Wistar Rats weighing (150–170) were divided into six groups (n=5). Group A served as control and received oral administration of phosphate buffer saline; group B received 800 mg/kg A. digitata only; group C were injected intraperitoneally with single dose 2 mg/kg b.w cadmium chloride; group D were injected intraperitoneally with single dose 2 mg/kg b.w cadmium chloride and treated with 800 mg/kg aqueous extract of A. digitata; group E received 300 mg/kg vitamin E only; group F were injected intraperitoneally with single dose 2 mg/kg b.w cadmium chloride and treated with 300 mg/kg vitamin E. After 21 days, the animals were sacrificed by cervical dislocation, the testes were excised fixed in Bouins fluids for histological analysis and the other homogenized in 5% sucrose solution for determination of tissue malondialdehyde (MDA) and antioxidant enzyme activity, biochemical assay.
Results
The group treated with cadmium chloride plus A. digitata caused significant decrease in MDA levels with significant increase (p<0.05) in antioxidant activities and biochemical enzymes when compared to cadmium chloride only group.
Conclusions
Aqueous extract of A. digitata appears to have ameliorative effect against cadmium chloride-induced testicular damage. This could be attributed to the presence of polyphenolic compound.
Acknowledgements
Not applicable.
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Research funding: The authors did not receive any form of internal or external funding for this work.
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Author contributions: All the authors significantly contributed to the manuscript. OTO and DJB contributed to the conceptualization, design of topic, searching of literature, carry out the experiment and write up, GEO, OOI, OE, contributed to the plagiarism check and English language editing, LIA contributed to the review and internal editing. All authors have read and approved the manuscript.
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Competing interests: The authors wish to declare that there is no competing interest.
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Informed consent: Not applicable.
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Ethical approval: The ethical approval on animal right was obtained from the Institutional Animal Care Committee of the same Institution with assigned number ERC/2016/06/04. All the experimental procedures were done following the experimental guidelines of the Institutional Animal Ethics Committee (IAEC) of Bingham University, Karu, Nasarawa State, Nigeria.
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Availability of data and material: The material used during the review work was made available from the corresponding author on request.
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Reviews
- An insight on safety, efficacy, and molecular docking study reports of N-acetylcysteine and its compound formulations
- Public health approach of Unani medicine to cope and stay safe in hot environmental conditions
- Original Articles
- Kinetic characterization of rat brain acetylcholinesterase modulated by lead and cartap: the ameliorative effect of Citrus limon fruit juice
- Attenuation of potassium dichromate and sodium arsenite toxicities by methanol extract of Rauvolfia vomitoria in mice
- Chronic exposure of industrial grade calcium carbide and ethylene glycol alter histological architecture of systemic organs by disrupting redox balance in rat
- Biochemical and histopathological effects of low dose vanadium in the healing of acetic acid-induced colitis in male wistar rats
- Glycine and L-Arginine supplementation ameliorates gastro-duodenal toxicity in a rat model of NSAID (Diclofenac)-gastroenteropathy via inhibition of oxidative stress
- Cocos nucifera L. oil alleviates lead acetate-induced reproductive toxicity in sexually-matured male Wistar rats
- Intracellular signaling molecules of nerve tissue progenitors as pharmacological targets for treatment of ethanol-induced neurodegeneration
- Glatiramer acetate treatment inhibits inflammatory responses and improves survival in a mice model of cecal ligation and puncture-induced sepsis
- Ciprofloxacin-induced cutaneous adverse drug events: a systematic review of descriptive studies
- Aqueous extract of Adansonia digitata prevents Cadmium Chloride-induced testicular damage in Wistar Rats
- Exposure to prolonged unpredictable light impairs spatial memory via induction of oxidative stress and tumor necrosis factor-alpha in rats
- Tamarindus indica. Linn leaves ameliorates experimental induced heart failure in Wistar rats
Artikel in diesem Heft
- Frontmatter
- Reviews
- An insight on safety, efficacy, and molecular docking study reports of N-acetylcysteine and its compound formulations
- Public health approach of Unani medicine to cope and stay safe in hot environmental conditions
- Original Articles
- Kinetic characterization of rat brain acetylcholinesterase modulated by lead and cartap: the ameliorative effect of Citrus limon fruit juice
- Attenuation of potassium dichromate and sodium arsenite toxicities by methanol extract of Rauvolfia vomitoria in mice
- Chronic exposure of industrial grade calcium carbide and ethylene glycol alter histological architecture of systemic organs by disrupting redox balance in rat
- Biochemical and histopathological effects of low dose vanadium in the healing of acetic acid-induced colitis in male wistar rats
- Glycine and L-Arginine supplementation ameliorates gastro-duodenal toxicity in a rat model of NSAID (Diclofenac)-gastroenteropathy via inhibition of oxidative stress
- Cocos nucifera L. oil alleviates lead acetate-induced reproductive toxicity in sexually-matured male Wistar rats
- Intracellular signaling molecules of nerve tissue progenitors as pharmacological targets for treatment of ethanol-induced neurodegeneration
- Glatiramer acetate treatment inhibits inflammatory responses and improves survival in a mice model of cecal ligation and puncture-induced sepsis
- Ciprofloxacin-induced cutaneous adverse drug events: a systematic review of descriptive studies
- Aqueous extract of Adansonia digitata prevents Cadmium Chloride-induced testicular damage in Wistar Rats
- Exposure to prolonged unpredictable light impairs spatial memory via induction of oxidative stress and tumor necrosis factor-alpha in rats
- Tamarindus indica. Linn leaves ameliorates experimental induced heart failure in Wistar rats
