Abstract
To date, a large number of synthetic drugs have been developed for the treatment and prevention of different disorders, such as neurodegenerative diseases, diabetes mellitus, and cancer. However, these drugs suffer from a variety of drawbacks including side effects and low efficacy. In response to this problem, researchers have focused on the plant-derived natural products due to their valuable biological activities and low side effects. Flavonoids consist of a wide range of naturally occurring compounds exclusively found in fruits and vegetables and demonstrate a number of pharmacological and therapeutic effects. Tangeretin (TGN) is a key member of flavonoids that is extensively found in citrus peels. It has different favorable biological activities such as antioxidant, anti-inflammatory, antitumor, hepatoprotective, and neuroprotective effects. In the present review, we discuss the various pharmacological and therapeutic effects of TGN and then, demonstrate how this naturally occurring compound affects signaling pathways to exert its impacts.
Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Editorial
- Anti-microbial stewardship: is it old wine in a new bottle?
- Reviews
- Tangeretin: a mechanistic review of its pharmacological and therapeutic effects
- Silymarin: not just another antioxidant
- Original Articles
- Melatonin ameliorates some biochemical alterations following ketoconazole administration in rats
- Quercetin modulates granulosa cell mRNA androgen receptor gene expression in dehydroepiandrosterone-induced polycystic ovary in Wistar rats via metabolic and hormonal pathways
- Comparative expression analysis of phospholipid binding protein annexina1 in nephrogenesis and kidney cancer
- Anthonotha macrophylla P. Beauv (Caesalpiniaceae) aqueous extract exhibits antiestrogenic effects in vitro and in vivo
- Urate crystals trigger B-cell receptor signal transduction and induce B-cell proliferation
- Effects of gabapentinoids on responses of primary cultures from rat dorsal root ganglia to inflammatory or somatosensory stimuli
- Anti-inflammatory potential of chia seeds oil and mucilage against adjuvant-induced arthritis in obese and non-obese rats
- Antiproliferative effects of combinational therapy of Lycopodium clavatum and quercetin in colon cancer cells
- Attenuation of oxidative stress and neurotoxicity involved in the antidepressant-like effect of the MK-801(dizocilpine) in Bacillus Calmette-Guerin-induced depression in mice
- 3-(Para-fluorobenzoyl)-propionic acid; a metabolite of haloperidol, reversed oestradiol valerate-induced uterine hyperplasia via modulation of oestrogen receptor signalling pathways in female Wistar rats
- Pharmacological evidence of Vitex thyrsiflora, Entandrophragma cylindricum, and Anonidium mannii used for the management of inflammation in Cameroon
- Mitigation of aflatoxin B1- and sodium arsenite-induced cytotoxicities in HUC-PC urinary bladder cells by curcumin and Khaya senegalensis
- Saccharum officinarum juice alters reproductive functions in male Wistar rats
- The effects of Pb on sperm parameters and sperm DNA fragmentation of men investigated for infertility
Articles in the same Issue
- Editorial
- Anti-microbial stewardship: is it old wine in a new bottle?
- Reviews
- Tangeretin: a mechanistic review of its pharmacological and therapeutic effects
- Silymarin: not just another antioxidant
- Original Articles
- Melatonin ameliorates some biochemical alterations following ketoconazole administration in rats
- Quercetin modulates granulosa cell mRNA androgen receptor gene expression in dehydroepiandrosterone-induced polycystic ovary in Wistar rats via metabolic and hormonal pathways
- Comparative expression analysis of phospholipid binding protein annexina1 in nephrogenesis and kidney cancer
- Anthonotha macrophylla P. Beauv (Caesalpiniaceae) aqueous extract exhibits antiestrogenic effects in vitro and in vivo
- Urate crystals trigger B-cell receptor signal transduction and induce B-cell proliferation
- Effects of gabapentinoids on responses of primary cultures from rat dorsal root ganglia to inflammatory or somatosensory stimuli
- Anti-inflammatory potential of chia seeds oil and mucilage against adjuvant-induced arthritis in obese and non-obese rats
- Antiproliferative effects of combinational therapy of Lycopodium clavatum and quercetin in colon cancer cells
- Attenuation of oxidative stress and neurotoxicity involved in the antidepressant-like effect of the MK-801(dizocilpine) in Bacillus Calmette-Guerin-induced depression in mice
- 3-(Para-fluorobenzoyl)-propionic acid; a metabolite of haloperidol, reversed oestradiol valerate-induced uterine hyperplasia via modulation of oestrogen receptor signalling pathways in female Wistar rats
- Pharmacological evidence of Vitex thyrsiflora, Entandrophragma cylindricum, and Anonidium mannii used for the management of inflammation in Cameroon
- Mitigation of aflatoxin B1- and sodium arsenite-induced cytotoxicities in HUC-PC urinary bladder cells by curcumin and Khaya senegalensis
- Saccharum officinarum juice alters reproductive functions in male Wistar rats
- The effects of Pb on sperm parameters and sperm DNA fragmentation of men investigated for infertility