Abstract
Background
The aim of this study was to know the present scenario of blood lead level and its effect on serum lipid peroxide and antioxidant parameters of spray painters.
Methods
We included 42 male spray painters and 50 control subjects with an age range of 20–45 years. Blood lead level, serum lipid peroxide and antioxidant parameters, i.e. erythrocyte catalase, superoxide dismutase (SOD), plasma ceruloplasmin, nitric oxide, uric acid and bilirubin, were quantified by standard methods.
Results
We observed the significant elevated blood lead (p < 0.001, 458%), lipid peroxide (p < 0.001, 170%), uric acid (p < 0.001, 25.6%) and bilirubin (p < 0.01, 24.5%) and the significant decrease in antioxidant enzymes like SOD (p < 0.001, −50.4%), catalase (p < 0.001, −34.33%), ceruloplasmin (p < 0.001, −32.7%) and nitric oxide (p < 0.001, −39.58%) in the study group as compared to control. A significant positive correlation coefficient (r) of blood lead level with lipid peroxide (r = 0.44, p < 0.001), uric acid (r = 0.33 p < 0.05) and bilirubin (r = 0.35, p < 0.05) and a negative correlation with SOD (r = −0.32, p < 0.05), catalase (r = −0.33, p < 0.05), ceruloplasmin (r = −0.27, p < 0.05) and nitric oxide (r = 0.30, p < 0.05) were observed.
Conclusions
Elevated blood lead level induces serum lipid peroxide and alters the antioxidant enzymes of spray painters. Therefore, it is necessary to reduce the blood lead level by taking proper precautions while spraying the paints, and additional antioxidant supplementation like vitamin C, multivitamin and multiminerals will be useful in reducing oxidative stress.
Acknowledgments
We express our deep gratitude to all the study subjects and healthy control subjects who consented to volunteer in this project. We also acknowledge the research facilities provided by the Krishna Institute of Medical Sciences “Deemed To Be University”, Karad. We are also grateful to the authors/editors/publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved its submission.
Research funding: Krishna Institute of Medical Sciences “Deemed To Be University”, Karad, Dist. Satara, Maharashtra, India.
Competing interests: The authors state no conflict of interest.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: Research involving human subjects complied with all relevant national regulations and institutional policies, is in accordance with the tenets of the Helsinki Declaration (as revised in 2013) and has been approved by the Institutional ethics committee and protocol committee approval [2016-2017/075]. ()).
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Articles in the same Issue
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- Cognitive impairments in type 2 diabetes, risk factors and preventive strategies
- Mini Review
- Possible therapeutic effect of magnesium in ocular diseases
- Original Articles
- Evaluation of habituation to visual evoked potentials using pattern reversal among migraine individuals – a cross-sectional study
- Cardiac autonomic modulation in response to stress in normotensive young adults with parental history of hypertension
- Increased blood lead level induces oxidative stress and alters the antioxidant status of spray painters
- Rescue role of hesperidin in 4-vinylcyclohexene diepoxide-induced toxicity in the brain, ovary and uterus of wistar rats
- Effects of selenium, zinc, insulin and metallothionein on cadmium-induced oxidative stress and metallothionein gene expression levels in diabetic rats
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- Trema orientalis (Linn.) leaves promotes anticancer activity in Ehrlich ascites carcinoma (EAC) in Swiss albino mice
- Antidiabetic and protective effects of Scrophularia striata ethanolic extract on diabetic nephropathy via suppression of RAGE and S100A8 expression in kidney tissues of streptozotocin-induced diabetic rats
- Effect of the methanol extract of the red cultivar Allium cepa L. on the serum biochemistry and electrolytes of rats following sub-chronic oral administration
Articles in the same Issue
- Reviews
- Omics-based biomarkers in the diagnosis of diabetes
- Cognitive impairments in type 2 diabetes, risk factors and preventive strategies
- Mini Review
- Possible therapeutic effect of magnesium in ocular diseases
- Original Articles
- Evaluation of habituation to visual evoked potentials using pattern reversal among migraine individuals – a cross-sectional study
- Cardiac autonomic modulation in response to stress in normotensive young adults with parental history of hypertension
- Increased blood lead level induces oxidative stress and alters the antioxidant status of spray painters
- Rescue role of hesperidin in 4-vinylcyclohexene diepoxide-induced toxicity in the brain, ovary and uterus of wistar rats
- Effects of selenium, zinc, insulin and metallothionein on cadmium-induced oxidative stress and metallothionein gene expression levels in diabetic rats
- Effect of insulin-loaded trimethyl chitosan nanoparticles on genes expression in the hippocampus of diabetic rats
- Persistent homeothermy in large domestic mammals maintained under standard farming conditions
- Toxicological, anticholinesterase, antilipidemic, antidiabetic and antioxidant potentials of Grewia optiva Drummond ex Burret extracts
- Trema orientalis (Linn.) leaves promotes anticancer activity in Ehrlich ascites carcinoma (EAC) in Swiss albino mice
- Antidiabetic and protective effects of Scrophularia striata ethanolic extract on diabetic nephropathy via suppression of RAGE and S100A8 expression in kidney tissues of streptozotocin-induced diabetic rats
- Effect of the methanol extract of the red cultivar Allium cepa L. on the serum biochemistry and electrolytes of rats following sub-chronic oral administration