Effect of caffeine on alcohol consumption and alcohol-induced conditioned place preference in rodents
-
Agbonlahor Okhuarobo
,
Abdulmajid Yahaya
Abstract
Background
The aim of the study was to determine the effect of caffeine on alcohol consumption with or without deprivation and alcohol-induced conditioned place preference.
Methods
In the present study, we examined the effects of caffeine (2.5, 5 and 10 mg/kg) on alcohol consumption in Wistar rats with or without periods of deprivation in an unlimited-access, two-bottle, free choice drinking procedure after a stable baseline alcohol consumption was established. Conditioned place preference (CPP) was established by intraperitoneal injections of alcohol (2 g/kg) in a 12-day conditioning schedule in mice. The effect of caffeine (3 mg/kg) on CPP expression was determined by a final post-conditioning test following 12 conditioning sessions with alcohol. The effect of caffeine (3 mg/kg) on the reinstatement of alcohol-induced CPP was determined in a final post-conditioning test following 12 conditioning sessions with alcohol and the extinction of alcohol-induced CPP.
Results
Alcohol deprivation for 3 days did not result in alcohol deprivation effect (ADE). While caffeine (10 mg/kg) caused a significant (p<0.05) reduction in alcohol consumption compared with the baseline following a period of alcohol deprivation, it did not cause a change in alcohol consumption compared with the baseline in the study without alcohol deprivation phase. Caffeine significantly (p<0.05) reduced the expression of alcohol-induced CPP compared to saline and blocked the reinstatement of alcohol-induced CPP following the injection of a priming dose (0.4 g/kg) of alcohol.
Conclusions
Given that caffeine is an adenosine receptor antagonist, our findings suggest a role for adenosine receptors in the alcohol reward and alcohol-seeking behaviour.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved its submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2019 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Reviews
- Immune response and inflammatory pathway of ulcerative colitis
- Current insights and future perspectives of hypoxia-inducible factor-targeted therapy in cancer
- Behavior and Neuroprotection
- Effect of caffeine on alcohol consumption and alcohol-induced conditioned place preference in rodents
- Reproduction
- Pubertal anabolic androgenic steroid exposure in male rats affects levels of gonadal steroids, mating frequency, and pregnancy outcome
- Dynamics of inflammatory reaction and oxidative stress across maternal serum, placenta and amniotic fluid in laboratory rats and the role played by genistein aglycone
- Cardiovascular-Pulmonary Interactions
- Local inhibition of carbonic anhydrase does not decrease sweat rate
- The standardized extract of Nigella sativa and its major ingredient, thymoquinone, ameliorates angiotensin II-induced hypertension in rats
- Correlation between the blood level of irisin and the severity of acute myocardial infarction in exercise-trained rats
- Oxidative Stress
- Zataria multiflora extract and carvacrol affect cardiotoxicity induced by Adriamycin in rat
- Attenuation of oxidative stress and hepatic damage by white butterfly (Clerodendrum volubile) leaves in streptozotocin-induced diabetes in rats
- Proline supplementation mitigates the early stage of liver injury in bile duct ligated rats
- Pravastatin attenuates testicular damage induced by doxorubicin – a stereological and histopatological study
- Metabolism
- Re-establishing normal diet following high fat-diet-induced obesity reverses the altered salivary composition in Wistar rats
- Phytotherapy
- In vivo analgesic effect of different extracts of Hopea odorata leaves in mice and in silico molecular docking and ADME/T property analysis of some isolated compounds from this plant
- Hepatoprotective activity of Tamarindus indica Linn stem bark ethanolic extract against hepatic damage induced by co-administration of antitubercular drugs isoniazid and rifampicin in Sprague Dawley rats
- Case Report
- Drug-induced optic neuropathy in a case of extensively drug-resistant pulmonary tuberculosis
Articles in the same Issue
- Frontmatter
- Reviews
- Immune response and inflammatory pathway of ulcerative colitis
- Current insights and future perspectives of hypoxia-inducible factor-targeted therapy in cancer
- Behavior and Neuroprotection
- Effect of caffeine on alcohol consumption and alcohol-induced conditioned place preference in rodents
- Reproduction
- Pubertal anabolic androgenic steroid exposure in male rats affects levels of gonadal steroids, mating frequency, and pregnancy outcome
- Dynamics of inflammatory reaction and oxidative stress across maternal serum, placenta and amniotic fluid in laboratory rats and the role played by genistein aglycone
- Cardiovascular-Pulmonary Interactions
- Local inhibition of carbonic anhydrase does not decrease sweat rate
- The standardized extract of Nigella sativa and its major ingredient, thymoquinone, ameliorates angiotensin II-induced hypertension in rats
- Correlation between the blood level of irisin and the severity of acute myocardial infarction in exercise-trained rats
- Oxidative Stress
- Zataria multiflora extract and carvacrol affect cardiotoxicity induced by Adriamycin in rat
- Attenuation of oxidative stress and hepatic damage by white butterfly (Clerodendrum volubile) leaves in streptozotocin-induced diabetes in rats
- Proline supplementation mitigates the early stage of liver injury in bile duct ligated rats
- Pravastatin attenuates testicular damage induced by doxorubicin – a stereological and histopatological study
- Metabolism
- Re-establishing normal diet following high fat-diet-induced obesity reverses the altered salivary composition in Wistar rats
- Phytotherapy
- In vivo analgesic effect of different extracts of Hopea odorata leaves in mice and in silico molecular docking and ADME/T property analysis of some isolated compounds from this plant
- Hepatoprotective activity of Tamarindus indica Linn stem bark ethanolic extract against hepatic damage induced by co-administration of antitubercular drugs isoniazid and rifampicin in Sprague Dawley rats
- Case Report
- Drug-induced optic neuropathy in a case of extensively drug-resistant pulmonary tuberculosis
