Blood troponin levels in acute cardiac events depends on space weather activity components (a correlative study)
-
Eliiyahu Stoupel
,
Richardas Radishauskas
Abstract
Background:
Many biological processes are influenced by space weather activity components such as solar activity (SA), geomagnetic activity (GMA) and cosmic ray activity (CRA). Examples are total mortality, acute myocardial infarction (AMI), stroke (cerebrovascular accident), sudden cardiac death, some congenital maladies (congenital heart disease and Down syndrome), many events in neonatology, ophtalmology, blood pressure regulation, blood coagulation, inflammation, etc. The aim of this study was to check if the level of blood troponins (Tns) – markers of myocardial damage and recognized components of modern description of AMI – is connected with the mentioned space weather parameters.
Methods:
Patients admitted to a 3000-bed tertiary university hospital in Kaunas, Lithuania, with suspected AMI were the object of the study. Data for the time between 2008 and 2013 – 72 consecutive months – were studied. Of the patients, 1896 (1398 male, 498 female) had elevated troponin I (Tn I) or troponin T (Tn T, sensitive Tn) levels. Normal values were 0.00–0.03 ng/mL for Tn I and 0.00–14.00 ng/mL for Tn T. Monthly means and standard deviation of Tn I and Tn T were compared with monthly markers of SA, GMA and CRA. Pearson correlation coefficients and their probabilities were established (in addition to the consecutive graphs of both comparing physical and biological data). The cosmophysical data came from space service institutions in the United States, Russia and Finland.
Results:
AMI was diagnosed in 1188 patients (62.66%), and intermediate coronary syndrome in 698 patients (36.81%). There were significant links of the Tn blood levels with four SA indices and CRA (neutron activity in imp/min); there was no significant correlation with GMA indices Ap and Cp (p=0.27 and p=0.235). Tn T levels significantly correlated with the GMA indices and not with the SA and CRA levels (Ap: r=0.77, p=0.0021; Cp: r=0.729, p=0.0047).
Conclusions:
First, the monthly level of blood Tn I in ACS is significantly correlated with the indices of SA (inverse) and with CRA (neutron); second, no significant correlation with the GMA indices was found; and third, the Tn T levels showed significant links with the GMA indices and none with SA and CRA (neutron).
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
References
1. Tchijevsky A. Effects des facteurs physiques de la nature sur les Elements nerveux l’activite nerveuse des animaux Home rapport presente su laboratoire practique de Zoo psychologie, V., Paris. Traite de climatoloie biologique et Medicale V 1925;1:672.Suche in Google Scholar
2. Tchijevsky AL. Terrestrial echo of the solar storms, 2nd ed. Moscow: Misl, 1976.Suche in Google Scholar
3. Sardon G, Faure M. Les taches solaires et la pathologie humaine. La Presse Medicale 1927;18:284–5.Suche in Google Scholar
4. Barnothhy JM. In: Biological effects of magnetic fields. New York: Plenum Press, 1964:93.10.1007/978-1-4757-0214-9_8Suche in Google Scholar
5. Rozhdestvenskaya E, Novikova K. The influence of solar activity on the blood fibrinolytic system. Med Referative J 1969;10:65–9.Suche in Google Scholar
6. Oranevski VN, Breus TK, Baevski RM, Rapoport SI, Petrov VM, Barsukova ZV, et al. Effect of geomagnetic activity on the functional status of the body. Biofizika 1998;43:819–26.Suche in Google Scholar PubMed
7. Stoupel E. Forecasting in cardiology. New York: John Wiley & Sons, 1976:141.Suche in Google Scholar
8. Stoupel E. Solar-terrestrial prediction: aspects for preventive medicine. In: Donnelly RF, editor. Solar-terrestrial predictions proceedings. Vol. 4. Boulder, CO: US NOAA, Space Environment Laboratory, 1980:G29–40.Suche in Google Scholar
9. Stoupel E. Space weather and timing of cardiovascular events: clinical cosmobiology. Saarbrucken: Lambert Academic Publishing, 2012.Suche in Google Scholar
10. Stoupel E, Kalediene R, Sauliune S, Abramson E, Shochat T. Space weather and human deaths distribution: 25 years observation (Lithuania 1989–2013). J Basic Clin Physiol Pharmacol 2015;26:1–9.10.1515/jbcpp-2014-0125Suche in Google Scholar PubMed
11. Stoupel E, Joshua H, Lahav J. Human blood coagulation parameters and geomagnetic activity. Eur J Int Med 1996;7:217–20.Suche in Google Scholar
12. Stoupel E, Abramson E, Gabbay U, Pick AI. Relationship between immunoglobulin levels and extremes of solar activity. Int J Biometeorol 1995;38:89–91.10.1007/BF01270665Suche in Google Scholar PubMed
13. Stoupel E, Monselize Y, Lahav J. Changes in autoimmune markers of the anti cardiolipin syndrome on days of extreme geomagnetic activity. J Basic Clin Physiol Pharmacol 2006;17:269–78.10.1515/JBCPP.2006.17.4.269Suche in Google Scholar PubMed
14. Stoupel E, Abramson E, Israelevich P, Sulkes J, Harell D. Dynamics of serum C-reactive protein(CRP) and cosmophysical activity. Eur J Int Med 2007;18:124–8.10.1016/j.ejim.2006.09.010Suche in Google Scholar PubMed
15. Stoupel E, Zabludovsky M, Wittenberg C, Boner G. Ambulatory blood pressure monitoring in patients with hypertension on days of high and low geomagnetic activity. Int J Hypertension 1998;39:293–4.Suche in Google Scholar
16. Stoupel E, Hod M, Shimshoni M, Friedman S, Ovadia J. Pregnancy induced hypertension in months with different cosmic activity. Clin Exper Obst Gynec 1990;17:7–12.Suche in Google Scholar
17. Stoupel E, Keret R, Assa S, Kaufman H, Shimshoni M, Laron Z. Secretion of growth hormone, prolactin and corticosteroids during different levels of geomagnetic activity. Neuroendocrinol Lett 1983;5:365–58.Suche in Google Scholar
18. Stoupel E, Keret R, Gil-Ad I, Assa S, Silbergeld A, Shimshoni M, et al. Secretion of growth hormone and prolactin in extreme periods of solar activity in solar cycle 21 (1976–1986). Neuroendocrinol Lett 1980;5:191–295.Suche in Google Scholar
19. Khabarova OI, Dimitrova S. Some proves of integrated influence of geomagnetic activity and weather changes on human health. Fundamental Space Research. Proceedings of Intern. Conference, 21-28.09. Sunny Beach, Bulgaria, 2008:306–9. ISBN 978-957-982-316-9.Suche in Google Scholar
20. Vencloviene J, Babarskiene R, Milvidaite I, Kubilius R, Stasionyte J. The effect of solar-geomagnetic activity during hospital admission on coronary events within 1 year in patients with acute coronary syndromes. Adv Space Res 2013;52: 2192–8.10.1016/j.asr.2013.09.025Suche in Google Scholar
21. Gurfinkel YI. Ischemic heart disease and solar activity. IIKC. Moscow: “Elfi-3”, 2004.Suche in Google Scholar
22. Saposhnikov D, Revich B, Gurfinkel Y, Naumova E. The influence of meteorologic and geomagnetic factors on acute myocardial infarction and brain stroke in Moscow, Russia. Int J Biometeorol 2014;58:799–808.10.1007/s00484-013-0660-0Suche in Google Scholar PubMed
23. Stoupel E, Israelevich P, Petrauskiene J, Kalediene R, Abramson E, Sulkes J. Cosmic ray activity and monthly number of deaths: a correlative study. J Basic Clin Physiol Pharmacol 2002;13:23–2.10.1515/JBCPP.2002.13.1.23Suche in Google Scholar PubMed
24. Stoupel E. Sudden cardiac death and ventricular extrasystoles on days with four levels of geomagnetic activity. J Basic Clin Physiol Pharmacol 1993;4:57–67.10.1515/JBCPP.1993.4.4.357Suche in Google Scholar PubMed
25. Stoupel E. Cardiac arrhythmia and geomagnetic activity. Indian Pacing Electrophysiology J 2006;6:49–53.Suche in Google Scholar
26. Stoupel E, Domarkiene S, Radishauskas R, Bernotiene G, Abramson E, Israelevich P, et al. Links between monthly rates of four types of acute myocardial infarction and their corresponding cosmophysical activity parameters. J Basic Clinic Physiol Pharmacol 2004;14:175–84.10.1515/JBCPP.2004.15.3-4.175Suche in Google Scholar
27. Stoupel E, Babayev E, Mustafa F, Abramson E, Israelevich P, Sulkes J. Acute myocardial infarction occurrence: environmental links – Baku 2003–2005 data. Med Sci Monitor 2007;13: BR175–9.Suche in Google Scholar
28. Stoupel E, Tamoshiunas A, Radishauskas R, Bernotiene G, Abramson E, Israelevich P. Neutrons and the plaque: AMI (n-8920) at days of zero GMA/high neutron activity (n-36) and the following days and week. Kaunas, Lithuania, 2000–2007. Clin Experiment Cardiol 2011;2:121–5.Suche in Google Scholar
29. Stoupel E, Abramson E, Israelevich P. Left anterior descending/right coronary arteries as culprit arteries in acute myocardial infarction (n-2011) in changing physical environment, percutaneous coronary intervention data (2000–2010). J Basic Clin Physiol Pharm 2011;22:91–6.10.1515/JBCPP.2011.024Suche in Google Scholar PubMed
30. Stoupel E, Abramson E, Domarkiene S, Shimshoni M, Sulkes J. Space proton flux and the temporal distribution of cardiovascular deaths. Intern J Biometeorol 1997;40:113–6.10.1007/s004840050029Suche in Google Scholar PubMed
31. Stoupel E, Radishauskas R, Bernotiene G, Vaichiulis V, Abramson E. Data about natural history of some acute coronary events at days of high cosmic ray (CRA) – neutron activity and following 48 hours (2000–2012). Health 2016;8:1–6.10.4236/health.2016.85042Suche in Google Scholar
32. AACC. Laboratory tests online. American Association of Clinical Chemistry. 2001@2016.Suche in Google Scholar
33. Stoupel E, Tamoshiunas A, Radishauskas R, Bagdoniene G, Abramson E, Sulkes J, et al. Acute myocardial infarction (AMI) and intermediate coronary syndrome (ICS). Health 2010;2: 129–32.10.4236/health.2010.22020Suche in Google Scholar
34. Ebrille E, Konecny T, Spacek R, Konecnny D, Jones P, Ambroz P, et al. Correlation of geomagnetic activity with implantable cardioverter defibrillator shocks and antitachycardia pacing. Mayo Clinic Proc 2015;90:202–8.10.1016/j.mayocp.2014.11.011Suche in Google Scholar PubMed PubMed Central
35. Stoupel E, Babayev ES, Abramson E, Sulkes J. Days of “Zero” level geomagnetic activity accompanied by the high neutron activity and dynamics of some medical events-Antipodes to geomagnetic storms. Health 2013;5:1–7.10.4236/health.2013.55113Suche in Google Scholar
36. Stoupel E, Israelevich P, Gabbay U, Abramson E, Petrauskiene J, Kalediene R, et al. Correlation of two levels of space proton flux with monthly distribution of deaths from cardiovascular disease and suicide. J Basic Clin Physiol Pharmacol 2000;1:63–71.10.1515/JBCPP.2000.11.1.63Suche in Google Scholar
37. Stoupel E. Considering space weather forces interaction on human health. The equilibrium paradigm in clinical cosmobiology: is it equal? J Basic Clin Physiol Pharmacol 2015;26:147–51.10.1515/jbcpp-2014-0059Suche in Google Scholar PubMed
38. Stoupel E, Babayev ES, Mustafa FR, Abramson E, Israelevich P, Sulkes J. Clinical cosmobiology – sudden cardiac death and daily/monthly geomagnetic, cosmic ray and solar activity – the Baku Study, (2003–2005). Sun Geosphere 2006;1:13–6.Suche in Google Scholar
39. Stoupel E, Kusniec J, Mazur A, Abramson E, Israelevich P, Strasberg B. Timing of life-threatening arrhythmias detected by implantable cardioverter-defibrillators in relation to changes in cosmophysical factors. Cardiol J 2008;15:1–4.Suche in Google Scholar
40. Stoupel E, Kusniec J, Golovchiner G, Abramson E, Kadmon U, Strasberg B. Association of electrical heart storm occurrence with environmental physical activity. Pacing Clin Electrophysiol 2014;37:1067–70.10.1111/pace.12383Suche in Google Scholar PubMed
41. Preliminary Report and Forecast of Solar Geophysical Data. Weekly NOAA-SESC (now SWPC), USAF http:/www.sec.noaa.Gov./weekly.html.Suche in Google Scholar
42. Solar Indices Bulletin (monthly) NOAA, National Geophysical Data Center, USA. Geomagnetic Indices Bulletin (monthly) NOAA, National Geophysical Center, USA.Suche in Google Scholar
43. Cosmic Data, monthly review, IZMIRAN, Russian Academy of Sciences.Suche in Google Scholar
44. Neutron Monitoring Data (daily, monthly, yearly) Moscow Neutron Monitoring Station, Russian Academy of Sciences.Suche in Google Scholar
45. Neutron Monitoring Data (daily, monthly, yearly), Oulu University, Finland.Suche in Google Scholar
46. Heckman G. (Ed.) Glossary of solar-terrestrial terms, NOAA, Space Environment Services Center, Boulder, Co, NOAA, USAF, 1988, revised 1992, 2014. DOC/NOAA/ERL/SEL/.Suche in Google Scholar
47. Maseri A, Fuster V. Is there a vulnerable atherosclerotic plaque. Circulation 2003;107:2068–73.10.1161/01.CIR.0000070585.48035.D1Suche in Google Scholar PubMed
48. Libby P. Vascular biology of atherosclerosis. Circulation 2003;91:56–64.10.1016/B978-1-4377-0398-6.00043-3Suche in Google Scholar
49. Stoupel E. Atherothrombosis: environmental links. J Basic Clin Physiol Pharmacol 2008;19:37–47.10.1515/JBCPP.2008.19.1.37Suche in Google Scholar PubMed
50. Sigl G. Ultra-high-energy cosmic rays: physics and astrophy. Science 2001;291:73–9.10.1126/science.291.5501.73Suche in Google Scholar PubMed
51. Aharonian F, Akhperanian AG, Bazer-Bachi AR, Belicke M, Benbow W, Berniohr K, et al. Discovery of very-high-energy gamma rays from the Galactic Centre ridge. Nature 2006;439:695–8.10.1038/nature04467Suche in Google Scholar PubMed
52. The Pierre Auger Collaboration. Correlation of the highest-energy cosmic rays with nearby extragalactic objects. Science 2007;318:938–43.10.1126/science.1151124Suche in Google Scholar PubMed
53. Dorman L. Cosmic ray’s as a factor and tool for forecasting of space weather influence on the biosphere. In: Space Weather effects on humans in space and on Earth, Vol. I. Moscow: Space Research Institute, 2013:92–109.Suche in Google Scholar
54. Nias AH. An introduction to radiotherapy. John Wiley & Sons, 1998, reprinted 2000.Suche in Google Scholar
55. Hall EJ, GIaccia AJ. Radiotherapy for radiologists. Philadelphia, Baltimore, New York, London, Buenos Aires, Hong Kong, Tokyo: Lippincott and Wilkins & Williams, 2006.Suche in Google Scholar
56. Stoupel E. Gene functional dynamics: environment as a trigger. J Basic Clin Physiol Pharmacol 2014;25:129–32.10.1515/jbcpp-2013-0112Suche in Google Scholar PubMed
©2018 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Review
- Calcium sensitization mechanisms in detrusor smooth muscles
- Opinion Paper
- The case for a distinctive philosophy of physiology and pathophysiology
- Behavior and Neuroprotection
- Effects of dizocilpine-induced glutamatergic blockade in the nucleus accumbens septi on the plus maze test
- Reproduction
- [6]-Gingerol modulates spermatotoxicity associated with ulcerative colitis and benzo[a]pyrene exposure in BALB/c mice
- Cardiovascular Function
- Blood troponin levels in acute cardiac events depends on space weather activity components (a correlative study)
- Effects of Trypanosoma brucei brucei infection and diminazene aceturate administration on the blood pressure, heart rate, and temperature of Wistar albino rats
- Oxidative Stress
- Dose-dependent effects of vitamin 1,25(OH)2D3 on oxidative stress and apoptosis
- Metabolism
- Losartan improves renal function and pathology in obese ZSF-1 rats
- Phytotherapy
- Evaluation of morning glory (Jacquemontia tamnifolia (L.) Griseb) leaves for antioxidant, antinociceptive, anticoagulant and cytotoxic activities
- Silymarin prevents lipid accumulation in the liver of rats with type 2 diabetes via sirtuin1 and SREBP-1c
Artikel in diesem Heft
- Frontmatter
- Review
- Calcium sensitization mechanisms in detrusor smooth muscles
- Opinion Paper
- The case for a distinctive philosophy of physiology and pathophysiology
- Behavior and Neuroprotection
- Effects of dizocilpine-induced glutamatergic blockade in the nucleus accumbens septi on the plus maze test
- Reproduction
- [6]-Gingerol modulates spermatotoxicity associated with ulcerative colitis and benzo[a]pyrene exposure in BALB/c mice
- Cardiovascular Function
- Blood troponin levels in acute cardiac events depends on space weather activity components (a correlative study)
- Effects of Trypanosoma brucei brucei infection and diminazene aceturate administration on the blood pressure, heart rate, and temperature of Wistar albino rats
- Oxidative Stress
- Dose-dependent effects of vitamin 1,25(OH)2D3 on oxidative stress and apoptosis
- Metabolism
- Losartan improves renal function and pathology in obese ZSF-1 rats
- Phytotherapy
- Evaluation of morning glory (Jacquemontia tamnifolia (L.) Griseb) leaves for antioxidant, antinociceptive, anticoagulant and cytotoxic activities
- Silymarin prevents lipid accumulation in the liver of rats with type 2 diabetes via sirtuin1 and SREBP-1c
