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Influence of age and gender on blood pressure variability and baroreflex sensitivity in a healthy population in the Indian sub-continent

  • Meghana Adoor ORCID logo , Sriranjini S. Jaideep , M.U. Sujan , Boris W. Kramer , T.R. Raju and Talakad N. Sathyaprabha EMAIL logo
Published/Copyright: July 14, 2018
Journal of Basic and Clinical Physiology and Pharmacology
From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 29 Issue 4

Abstract

Background

The current exploratory study was aimed at estimating measures of blood pressure variability (BPV) and baroreflex sensitivity (BRS) in a healthy population in the Indian sub-continent.

Methods

One hundred and forty-two healthy subjects were recruited for the study. Blood pressure (BP) was recorded continuously for 15 min using the Finometer (Finapres Medical Systems, The Netherlands). For offline analysis, Nevrokard cardiovascular parameter analysis (CVPA) software (version 2.1.0) was used for BPV analysis. BRS was determined by spectral and sequence methods. One-way ANOVA and Bonferroni’s test were used to compare parameters. Pearson’s correlation coefficient was employed to look for possible associations between age and other continuous variables.

Results

Out of 196 screened volunteers, 54 were excluded and 142 subjects were grouped based on ages as 10–19 years (group 1), 20–29 years (group 2), 30–39 years (group 3), 40–49 years (group 4), and 50–59 years (group 5). Within groups, body mass index (BMI, p=0.000) and BP (systolic and diastolic) were significantly different. Post hoc analysis showed mean blood pressure (MBP) and diastolic blood pressure (DBP) differing significantly between groups 1 and 4 (p<0.05 for both) along with other cardiovascular parameters. Age correlated positively with BMI and all parameters of BP. Significant gender differences were observed for stroke volume, cardiac output, up BRS, total BRS, peripheral resistance (PR), and aortic impedance.

Conclusions

Our study has provided reference values for BPV and BRS in an Indian population. It also indicates age-related neurocardiac imbalance and possible utility of these tests for screening at the start of neurocardiac damage in a healthy population.

Keywords: age; baroreflex sensitivity; blood pressure variability; gender

Acknowledgments

We are grateful to the study volunteers for their participation.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2017-08-09
Accepted: 2018-01-03
Published Online: 2018-07-14
Published in Print: 2018-07-26

©2018 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jbcpp-2017-0125
Keywords for this article
age; baroreflex sensitivity; blood pressure variability; gender

Articles in the same Issue

  1. Frontmatter
  2. Letter to the Editor
  3. Blister-packed levothyroxine sodium or bottle-packed levothyroxine sodium
  4. Metabolism
  5. Comparative hypoglycemic potentials and phytochemical profiles of 12 common leafy culinary vegetables consumed in Nsukka, Southeastern Nigeria
  6. Infection
  7. The effects of oral pregabalin on post-Lichtenstein herniorrhaphic pain: a randomized clinical trial
  8. Cardiovascular Function
  9. Influence of age and gender on blood pressure variability and baroreflex sensitivity in a healthy population in the Indian sub-continent
  10. Autonomic responses during acute myocardial infarction in the rat model: implications for arrhythmogenesis
  11. Phytotherapy
  12. Role of reactive oxygen species–total antioxidant capacity status in Telfairia occidentalis leaves–associated spermatoprotective effect: a pointer to fatty acids benefit
  13. Antidiabetic and renoprotective effect of Anogeissus acuminata leaf extract on experimentally induced diabetic nephropathy
  14. Oxidative Stress
  15. Aged coconut oil with a high peroxide value induces oxidative stress and tissue damage in mercury-treated rats
  16. Anti-ulcerogenic effect of the methanol extract of Chasmanthera dependens (Hochst) stem on male Wistar rats
  17. Hematological Profile
  18. Evaluation of hematological alterations after therapeutic use of dipyrone in healthy adults: a prospective study
  19. Hematology and erythrocyte osmotic fragility of the Franquet’s fruit bat (Epomops franqueti)
  20. Behavior and Neuroprotection
  21. Haloperidol-induced parkinsonism is attenuated by varenicline in mice
  22. Antioxidant-mediated neuroprotection by Allium schoenoprasum L. leaf extract against ischemia reperfusion-induced cerebral injury in mice
  23. Effects of acetone extract of Cola nitida on brain sodium-potassium adenosine triphosphatase activity and spatial memory in healthy and streptozotocin-induced diabetic female Wistar rats
  24. Case Report
  25. Conservative treatment of postoperative chylothorax: a case report
  26. Short Communication
  27. Improved serotonergic neurotransmission by genistein pretreatment regulates symptoms of obsessive-compulsive disorder in streptozotocin-induced diabetic mice
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