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Aged coconut oil with a high peroxide value induces oxidative stress and tissue damage in mercury-treated rats

  • Sunny O. Abarikwu EMAIL logo , Rex-Clovis C. Njoku and Chigozie L. Onuah
Published/Copyright: March 23, 2018
Journal of Basic and Clinical Physiology and Pharmacology
From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 29 Issue 4

Abstract

Background

Exposure to mercury (Hg) and the ingestion of peroxidized edible oil represent a health risk. This study evaluated the effects of peroxidized coconut oil (CO) on the liver and kidney of rats treated with Hg.

Methods

Male albino Wistar rats were administered HgCl2 and CO separately or as a combination for 21 days. The concentrations of glutathione (GSH) and malondialdehyde (MDA), as well as the activities of superoxide dismutase (SOD) and catalase (CAT), which were used as markers of oxidative stress were measured in the liver and kidney homogenates. The activities of gamma glutamyl transferase (γ-GT), lactate dehydrogenase (LDH) as well as the levels of bilirubin and creatinine (CREA) as markers of liver and kidney functions were analyzed in the serum.

Results

The level of MDA in the kidney and liver homogenates was significantly increased in the HgCl2, CO, and CO+HgCl2 groups when compared to control values (p<0.05). Liver SOD activity and GSH level were increased and CAT activity was decreased, whereas kidney GSH level and SOD activity were decreased and CAT activity was increased in the CO and CO+HgCl2 groups when compared to control values (p<0.05). The increase in CREA and bilirubin levels as well as γ-GT and LDH activities observed in the CO+HgCl2 group when compared to the control values (p<0.05) were associated with pathological changes in both tissues, and were considered to be due to oxidative stress.

Conclusions

In summary, peroxidized CO and Hg alone or in combination induces oxidative damage in the liver and kidney of rats.

Keywords: aged coconut oil; kidney; lipid peroxidation; liver; mercury; peroxidation
Corresponding author: Sunny O. Abarikwu, PhD, Department of Biochemistry, Faculty of Science, University of Port Harcourt, P.M.B. 5323 Port Harcourt, Choba, Nigeria, Phone: +234-8030505464, +234-8161346531, Fax: +234-84230903, E-mail:

Acknowledgment

The technical expertise of Christian Kingsley Nwaugha (Department of Biochemistry, University of Port Harcourt) on animal handling and collection of blood samples is gratefully acknowledged.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2016-09-09
Accepted: 2018-01-09
Published Online: 2018-03-23
Published in Print: 2018-07-26

©2018 Walter de Gruyter GmbH, Berlin/Boston

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  2. Letter to the Editor
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  11. Phytotherapy
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  13. Antidiabetic and renoprotective effect of Anogeissus acuminata leaf extract on experimentally induced diabetic nephropathy
  14. Oxidative Stress
  15. Aged coconut oil with a high peroxide value induces oxidative stress and tissue damage in mercury-treated rats
  16. Anti-ulcerogenic effect of the methanol extract of Chasmanthera dependens (Hochst) stem on male Wistar rats
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  20. Behavior and Neuroprotection
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  24. Case Report
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  26. Short Communication
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https://doi.org/10.1515/jbcpp-2016-0138
Keywords for this article
aged coconut oil; kidney; lipid peroxidation; liver; mercury; peroxidation

Articles in the same Issue

  1. Frontmatter
  2. Letter to the Editor
  3. Blister-packed levothyroxine sodium or bottle-packed levothyroxine sodium
  4. Metabolism
  5. Comparative hypoglycemic potentials and phytochemical profiles of 12 common leafy culinary vegetables consumed in Nsukka, Southeastern Nigeria
  6. Infection
  7. The effects of oral pregabalin on post-Lichtenstein herniorrhaphic pain: a randomized clinical trial
  8. Cardiovascular Function
  9. Influence of age and gender on blood pressure variability and baroreflex sensitivity in a healthy population in the Indian sub-continent
  10. Autonomic responses during acute myocardial infarction in the rat model: implications for arrhythmogenesis
  11. Phytotherapy
  12. Role of reactive oxygen species–total antioxidant capacity status in Telfairia occidentalis leaves–associated spermatoprotective effect: a pointer to fatty acids benefit
  13. Antidiabetic and renoprotective effect of Anogeissus acuminata leaf extract on experimentally induced diabetic nephropathy
  14. Oxidative Stress
  15. Aged coconut oil with a high peroxide value induces oxidative stress and tissue damage in mercury-treated rats
  16. Anti-ulcerogenic effect of the methanol extract of Chasmanthera dependens (Hochst) stem on male Wistar rats
  17. Hematological Profile
  18. Evaluation of hematological alterations after therapeutic use of dipyrone in healthy adults: a prospective study
  19. Hematology and erythrocyte osmotic fragility of the Franquet’s fruit bat (Epomops franqueti)
  20. Behavior and Neuroprotection
  21. Haloperidol-induced parkinsonism is attenuated by varenicline in mice
  22. Antioxidant-mediated neuroprotection by Allium schoenoprasum L. leaf extract against ischemia reperfusion-induced cerebral injury in mice
  23. Effects of acetone extract of Cola nitida on brain sodium-potassium adenosine triphosphatase activity and spatial memory in healthy and streptozotocin-induced diabetic female Wistar rats
  24. Case Report
  25. Conservative treatment of postoperative chylothorax: a case report
  26. Short Communication
  27. Improved serotonergic neurotransmission by genistein pretreatment regulates symptoms of obsessive-compulsive disorder in streptozotocin-induced diabetic mice
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