Effect of flavonol and its dimethoxy derivatives on paclitaxel-induced peripheral neuropathy in mice
-
Vijaykumar Sayeli
,
Jagan Nadipelly
Abstract
Background:
Peripheral neuropathy is the dose limiting side effect of many anticancer drugs. Flavonoids exhibit good antinociceptive effect in animal models. Their efficacy against different types of nociception has been documented. The present study investigated the effect of flavonol (3-hydroxy flavone), 3′,4′-dimethoxy flavonol, 6,3′-dimethoxy flavonol, 7,2′-dimethoxy flavonol and 7,3′-dimethoxy flavonol against paclitaxel-induced peripheral neuropathy in mice.
Methods:
A single dose of paclitaxel (10 mg/kg, i.p.) was administered to induce peripheral neuropathy in mice and the manifestations of peripheral neuropathy such as tactile allodynia, cold allodynia and thermal hyperalgesia were assessed 24 h later by employing Von Frey hair aesthesiometer test, acetone bubble test and hot water tail immersion test, respectively. The test compounds were prepared as a suspension in 0.5% carboxymethyl cellulose and were administered s.c. in various doses (25, 50, 100 and 200 mg/kg). The above behavioral responses were assessed prior to and 30 min after drug treatment. In addition, the effect of test compounds on proinflammatory cytokines like tumor necrosis factor-alpha (TNF-α), interleukin-1-beta (IL-1β) and free radicals was investigated by using suitable in vitro assays.
Results:
A dose-dependent attenuation of tactile allodynia, cold allodynia and thermal hyperalgesia was evidenced in mice treated with flavonol derivatives. The test compounds inhibited TNF-α, IL-1β and free radicals in a concentration-dependent manner.
Conclusions:
These results revealed that flavonol and its dimethoxy derivatives ameliorated the manifestations of paclitaxel-induced peripheral neuropathy in mice. The inhibition of proinflammatory cytokines and free radicals could contribute to this beneficial effect.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2018 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Review
- Rabbits and men: relating their ages
- Minireview
- Orphan drugs: trends and issues in drug development
- Phytotherapy
- Influence of Loranthus micranthus on hepatic and renal antioxidant status and impaired glycolytic flux in streptozotocin-induced diabetic rats
- Garlic (Allium sativum) increases SIRT1 and SIRT2 gene expressions in the kidney and liver tissues of STZ- and STZ+niacinamide-induced diabetic rats
- Reproduction
- A comparative study of the effect of stress on the cognitive parameters in women with increased body mass index before and after menopause
- Comparative effect of the aqueous extracts of Aloe buettneri, Dicliptera verticillata, Hibiscus macranthus and Justicia insularis on the sexual maturation of pregnant mare serum gonadotrophin-primed immature female rats
- Oxidative Stress
- Effect of L-carnitine on the skeletal muscle contractility in simvastatin-induced myopathy in rats
- Infection
- Anti-plasmodial activity of sodium acetate in Plasmodium berghei-infected mice
- Vascular Conditions
- Role of atrial natriuretic peptide in controlling diabetic nephropathy in rats
- Inflammation
- Anti-inflammatory and insulin secretory activity in experimental type-2 diabetic rats treated orally with magnesium
- Effects of artemisinin, with or without lumefantrine and amodiaquine on gastric ulcer healing in rat
- Behavior and Neuroprotection
- Effect of flavonol and its dimethoxy derivatives on paclitaxel-induced peripheral neuropathy in mice
- Hematological Profile
- Interactive effects of alcohol and chloroquine on hematologic profile of Wistar rats
- Metabolism
- Effects of α-(prazosin and yohimbine) and β-receptors activity on cAMP generation and UCP1 gene expression in brown adipocytes
- Differential sensitivity of chronic high-fat-diet-induced obesity in Sprague-Dawley rats
- Cardiovascular-Pulmonary Interactions
- A pilot study exploring the impact of cardiac medications on ciliary beat frequency: possible implications for clinical management
- Genotoxicity and Cytotoxicity
- Effects of a new chlorhexidine varnish on Streptococcus mutans biofilm formation in vitro
Artikel in diesem Heft
- Frontmatter
- Review
- Rabbits and men: relating their ages
- Minireview
- Orphan drugs: trends and issues in drug development
- Phytotherapy
- Influence of Loranthus micranthus on hepatic and renal antioxidant status and impaired glycolytic flux in streptozotocin-induced diabetic rats
- Garlic (Allium sativum) increases SIRT1 and SIRT2 gene expressions in the kidney and liver tissues of STZ- and STZ+niacinamide-induced diabetic rats
- Reproduction
- A comparative study of the effect of stress on the cognitive parameters in women with increased body mass index before and after menopause
- Comparative effect of the aqueous extracts of Aloe buettneri, Dicliptera verticillata, Hibiscus macranthus and Justicia insularis on the sexual maturation of pregnant mare serum gonadotrophin-primed immature female rats
- Oxidative Stress
- Effect of L-carnitine on the skeletal muscle contractility in simvastatin-induced myopathy in rats
- Infection
- Anti-plasmodial activity of sodium acetate in Plasmodium berghei-infected mice
- Vascular Conditions
- Role of atrial natriuretic peptide in controlling diabetic nephropathy in rats
- Inflammation
- Anti-inflammatory and insulin secretory activity in experimental type-2 diabetic rats treated orally with magnesium
- Effects of artemisinin, with or without lumefantrine and amodiaquine on gastric ulcer healing in rat
- Behavior and Neuroprotection
- Effect of flavonol and its dimethoxy derivatives on paclitaxel-induced peripheral neuropathy in mice
- Hematological Profile
- Interactive effects of alcohol and chloroquine on hematologic profile of Wistar rats
- Metabolism
- Effects of α-(prazosin and yohimbine) and β-receptors activity on cAMP generation and UCP1 gene expression in brown adipocytes
- Differential sensitivity of chronic high-fat-diet-induced obesity in Sprague-Dawley rats
- Cardiovascular-Pulmonary Interactions
- A pilot study exploring the impact of cardiac medications on ciliary beat frequency: possible implications for clinical management
- Genotoxicity and Cytotoxicity
- Effects of a new chlorhexidine varnish on Streptococcus mutans biofilm formation in vitro
