Comparative study of the efficacy and safety of theophylline and doxofylline in patients with bronchial asthma and chronic obstructive pulmonary disease
Abstract
Background: Bronchial asthma and chronic obstructive pulmonary disease (COPD) are the major obstructive disorders that may contribute to the severity in individual patients. The present study was designed to compare the efficacy and safety of theophylline and doxofylline in patients with bronchial asthma and COPD.
Methods: A total of 60 patients, 30 each with bronchial asthma and COPD, were enrolled for the study. Each group of 30 patients received standard treatment for asthma and COPD. Each group was again subdivided into two with 15 patients each, who received theophylline or doxofylline in addition to standard therapy, for a period of 2 months. Each patient was followed up fortnightly for the assessment of efficacy parameters using a pulmonary function test (PFT), clinical symptoms and emergency drug use, and safety was assessed by recording adverse drug reactions.
Results: Both theophylline and doxofylline produced enhancements in PFT at different time intervals in both asthma and COPD patients. The maximum beneficial effects were seen at 6 weeks for asthma patients and at 8 weeks for COPD patients for both theophylline and doxofylline.
Conclusions: The comparative study showed that doxofylline was more effective as evidenced by improvement in PFT as well as clinical symptoms, and reduced incidence of adverse effects and emergency bronchodilator use.
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©2015 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Review
- Implications of sodium hydrogen exchangers in various brain diseases
- Mini Review
- A perspective on role of calcium and vitamin D in cardiovascular outcomes and lipid profile
- Cardiovascular Function
- Space weather and human deaths distribution: 25 years’ observation (Lithuania, 1989–2013)
- Cardiovascular-Pulmonary Interactions
- Comparative study of the efficacy and safety of theophylline and doxofylline in patients with bronchial asthma and chronic obstructive pulmonary disease
- Oxidative Stress
- Antioxidant and cytotoxic activity of stems of Smilax zeylanica in vitro
- Hepatoprotective and antioxidant activity of hydromethanolic extract of Daniella oliveri leaves in carbon tetrachloride-induced hepatotoxicity in rats
- Inhibition of metalloproteinase and proteasome activities in colon cancer cells by citrus peel extracts
- Inflammation
- Analgesic and anti-inflammatory activity of Tectona grandis Linn. stem extract
- Cyperus rotundus L. prevents non-steroidal anti-inflammatory drug-induced gastric mucosal damage by inhibiting oxidative stress
- Evaluation of the analgesic, anti-inflammatory, anti-oxidant, phytochemical and toxicological properties of the methanolic leaf extract of commercially processed Moringa oleifera in some laboratory animals
- Jobelyn® exhibited anti-inflammatory, antioxidant, and membrane-stabilizing activities in experimental models
- Phytotherapy
- Effect of Saraca asoca (Asoka) on estradiol-induced keratinizing metaplasia in rat uterus
- Others
- The effect of nicotine and cotinine on human gingival fibroblasts attachment to root surfaces
- Congress Abstracts
- Israel Society for Auditory Research (ISAR) 2015 Annual Scientific Conference
Artikel in diesem Heft
- Frontmatter
- Review
- Implications of sodium hydrogen exchangers in various brain diseases
- Mini Review
- A perspective on role of calcium and vitamin D in cardiovascular outcomes and lipid profile
- Cardiovascular Function
- Space weather and human deaths distribution: 25 years’ observation (Lithuania, 1989–2013)
- Cardiovascular-Pulmonary Interactions
- Comparative study of the efficacy and safety of theophylline and doxofylline in patients with bronchial asthma and chronic obstructive pulmonary disease
- Oxidative Stress
- Antioxidant and cytotoxic activity of stems of Smilax zeylanica in vitro
- Hepatoprotective and antioxidant activity of hydromethanolic extract of Daniella oliveri leaves in carbon tetrachloride-induced hepatotoxicity in rats
- Inhibition of metalloproteinase and proteasome activities in colon cancer cells by citrus peel extracts
- Inflammation
- Analgesic and anti-inflammatory activity of Tectona grandis Linn. stem extract
- Cyperus rotundus L. prevents non-steroidal anti-inflammatory drug-induced gastric mucosal damage by inhibiting oxidative stress
- Evaluation of the analgesic, anti-inflammatory, anti-oxidant, phytochemical and toxicological properties of the methanolic leaf extract of commercially processed Moringa oleifera in some laboratory animals
- Jobelyn® exhibited anti-inflammatory, antioxidant, and membrane-stabilizing activities in experimental models
- Phytotherapy
- Effect of Saraca asoca (Asoka) on estradiol-induced keratinizing metaplasia in rat uterus
- Others
- The effect of nicotine and cotinine on human gingival fibroblasts attachment to root surfaces
- Congress Abstracts
- Israel Society for Auditory Research (ISAR) 2015 Annual Scientific Conference