Abstract
Background: The objective of this work was to study the analgesic and anti-inflammatory activity of Tectona grandis Linn. (TG) stem extract.
Methods: Healthy albino rats (150–200 g) and mice (25–50 g) were arranged and divided into five groups. Group 1 received distilled water and served as control, groups 2, 3, 4 were treated with TG stem extract (100, 200, 400 mg/kg) and group 5 received standard drug. For analgesic activity, the radiant heat method and writhing test were used, and for anti-inflammatory activity, the paw oedema model and granuloma pouch method were used. Statistical analysis was done by one-way analysis of variance followed by the t-test.
Results: In the radiant heat method, there was a dose-dependent increase in reaction time in TG stem extract (100, 200, 400 mg/kg) and standard drug (buprenorphine). In the writhing test, TG stem extract (200, 400 mg/kg) and aspirin decreased the number of writhes which was significant (p<0.01, p<0.001) as compared to controls. The percentage protection was 8.88%, 15.55%, 22.22% and 35.55% in groups 2, 3, 4 and 5, respectively. In the rat paw oedema test, TG stem extract (200, 400 mg/kg) and aspirin showed 20%, 40% and 54% inhibition of oedema which was statistically significant (p<0.05, p<0.01, p<0.001), respectively, as compared to control at the end of 4 h. In the granuloma pouch method, TG stem extract (100, 200, 400 mg/kg) and aspirin showed 13.33%, 22.22%, 33.33% and 66.66% inhibition of granuloma, respectively, which was significant (p<0.05, p<0.01, p<0.001).
Conclusions: TG stem extract possesses significant anti-inflammatory and analgesic activity.
References
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©2015 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Review
- Implications of sodium hydrogen exchangers in various brain diseases
- Mini Review
- A perspective on role of calcium and vitamin D in cardiovascular outcomes and lipid profile
- Cardiovascular Function
- Space weather and human deaths distribution: 25 years’ observation (Lithuania, 1989–2013)
- Cardiovascular-Pulmonary Interactions
- Comparative study of the efficacy and safety of theophylline and doxofylline in patients with bronchial asthma and chronic obstructive pulmonary disease
- Oxidative Stress
- Antioxidant and cytotoxic activity of stems of Smilax zeylanica in vitro
- Hepatoprotective and antioxidant activity of hydromethanolic extract of Daniella oliveri leaves in carbon tetrachloride-induced hepatotoxicity in rats
- Inhibition of metalloproteinase and proteasome activities in colon cancer cells by citrus peel extracts
- Inflammation
- Analgesic and anti-inflammatory activity of Tectona grandis Linn. stem extract
- Cyperus rotundus L. prevents non-steroidal anti-inflammatory drug-induced gastric mucosal damage by inhibiting oxidative stress
- Evaluation of the analgesic, anti-inflammatory, anti-oxidant, phytochemical and toxicological properties of the methanolic leaf extract of commercially processed Moringa oleifera in some laboratory animals
- Jobelyn® exhibited anti-inflammatory, antioxidant, and membrane-stabilizing activities in experimental models
- Phytotherapy
- Effect of Saraca asoca (Asoka) on estradiol-induced keratinizing metaplasia in rat uterus
- Others
- The effect of nicotine and cotinine on human gingival fibroblasts attachment to root surfaces
- Congress Abstracts
- Israel Society for Auditory Research (ISAR) 2015 Annual Scientific Conference
Artikel in diesem Heft
- Frontmatter
- Review
- Implications of sodium hydrogen exchangers in various brain diseases
- Mini Review
- A perspective on role of calcium and vitamin D in cardiovascular outcomes and lipid profile
- Cardiovascular Function
- Space weather and human deaths distribution: 25 years’ observation (Lithuania, 1989–2013)
- Cardiovascular-Pulmonary Interactions
- Comparative study of the efficacy and safety of theophylline and doxofylline in patients with bronchial asthma and chronic obstructive pulmonary disease
- Oxidative Stress
- Antioxidant and cytotoxic activity of stems of Smilax zeylanica in vitro
- Hepatoprotective and antioxidant activity of hydromethanolic extract of Daniella oliveri leaves in carbon tetrachloride-induced hepatotoxicity in rats
- Inhibition of metalloproteinase and proteasome activities in colon cancer cells by citrus peel extracts
- Inflammation
- Analgesic and anti-inflammatory activity of Tectona grandis Linn. stem extract
- Cyperus rotundus L. prevents non-steroidal anti-inflammatory drug-induced gastric mucosal damage by inhibiting oxidative stress
- Evaluation of the analgesic, anti-inflammatory, anti-oxidant, phytochemical and toxicological properties of the methanolic leaf extract of commercially processed Moringa oleifera in some laboratory animals
- Jobelyn® exhibited anti-inflammatory, antioxidant, and membrane-stabilizing activities in experimental models
- Phytotherapy
- Effect of Saraca asoca (Asoka) on estradiol-induced keratinizing metaplasia in rat uterus
- Others
- The effect of nicotine and cotinine on human gingival fibroblasts attachment to root surfaces
- Congress Abstracts
- Israel Society for Auditory Research (ISAR) 2015 Annual Scientific Conference