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Hyaluronic acid/κ-carrageenan films for mupirocin-controlled delivery

  • Tamara Rodrigues de Sousa , Sayza Dias de Santana , Grasiele Soares Cavallini and Nelson Luis Gonçalves Dias de Souza EMAIL logo
Published/Copyright: November 25, 2024
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International Polymer Processing
From the journal International Polymer Processing Volume 40 Issue 1

Abstract

The duration of lesions is a matter of public health concern and requires the development and application of new materials to achieve satisfactory results in disease treatment. Polymeric films are promising options for controlled drug delivery, enabling improved drug delivery and treatment efficiency. The aim of this study is to develop natural polymeric films for the controlled release of mupirocin. Films based on combinations of κ-carrageenan and hyaluronic acid, crosslinked with Zn2+, were developed. Vibrational spectroscopy (Raman and infrared spectroscopies) was used to characterize the chemical structure and crosslinking process. Micro-Raman imaging and scanning electron microscopy were employed to observe the spatial distribution of the polymers and morphology of the samples, respectively. The uniformity of mass, thickness, and MUP concentration was, respectively, 0.0082 ± 0.0021 g, 0.2500 ± 0.0354 mm, and 3.751 ± 0.6242 % for film 1; 0.0045 ± 0.0009 g, 0.1000 ± 0.0224 mm, and 4.086 ± 0.3673 % for film 2; and 0.0030 ± 0.0010 g, 0.1000 ± 0.0606 mm, and 4.052 ± 0.3468 % for film 3. The percentages of antibiotics present in the films were lower than the total amount of antibiotics added (8.0 %), suggesting that losses occurred during film production. Swelling and release kinetics studies showed that the films had a good swelling capacity and controlled the drug release process. The antibacterial activities of the films against Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, and Pseudomonas aeruginosa was determined using the inhibition zone method. The best activity was observed for the films containing 50 % hyaluronic acid and 50 % carrageenan. The results demonstrated that the carbohydrates used and crosslinking process can potentially be utilized for the controlled delivery of mupirocin.

Keywords: zinc(II); antibacterial; kinetics; permeation
Corresponding author: Nelson Luis Gonçalves Dias de Souza, Postgraduate Program in Chemistry, Federal University of Tocantins, Gurupi, TO, Brazil; and Graduation in Environmental Chemistry, Federal University of Tocantins, Gurupi, TO, Brazil, E-mail:

Acknowledgments

Brazilian National Council for Scientific and Technological Development – CNPq, Coordination of Superior Level Staff Improvement – CAPES/Brazil, The Foundation for Research of the State of Minas Gerais – FAPEMIG/Brazil, Federal University of Juiz de Fora – UFJF/Brazil, Spectroscopy and Molecular Structure Nucleus (NEEM/UFJF), Research Productivity Scholarship by the Tocantins Research Support Foundation – FAPT and Federal University of Tocantins – UFT/Brazil.

  1. Research ethics: All research has been conducted in accordance with the highest international and local standards of scientific rigour and integrity.

  2. Informed consent: Not applicable.

  3. Author contributions: Conceptualization: Grasiele Soares Cavallini and Nelson Luis Gonçalves Dias de Souza. Investigation: Tamara Rodrigues de Sousa, Sayza Dias de Santana. Data curation: Tamara Rodrigues de Sousa, Grasiele Soares Cavallini and Nelson Luis Gonçalves Dias de Souza. Writing: Tamara Rodrigues de Sousa and Nelson Luis Gonçalves Dias de Souza. The authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Use of Large Language Models, AI and Machine Learning Tools: None declared.

  5. Conflict of interest: The authors states no conflict of interest.

  6. Research funding: None declared.

  7. Data availability: Not applicable.

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Received: 2024-01-21
Accepted: 2024-10-08
Published Online: 2024-11-25
Published in Print: 2025-03-26

© 2024 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/ipp-2024-0018
Keywords for this article
zinc(II); antibacterial; kinetics; permeation

Articles in the same Issue

  1. Frontmatter
  2. Review Article
  3. Epoxy vitrimers: from essence to utility
  4. Research Articles
  5. Tamarind seed powder as filler in polypropylene and its impact on the mechanical and biodegradability of the composites
  6. Development and characterization of glass fiber composites impregnated with limestone powder and bagasse fiber
  7. Hyaluronic acid/κ-carrageenan films for mupirocin-controlled delivery
  8. Temperature field study and numerical computation of carbon fiber epoxy composite materials under unilateral thermal radiation
  9. 2D dendritic thermal growth pulsations: diffusion field associated with the transport of heat for application in organic-based systems
  10. Influence of different surface textures on wettability of UHMWPE and POM- an experimental study
  11. Use of machine learning methods for modelling mechanical parameters of PLA and PLA/native potato starch compound using aging data
  12. Influence of the viscosity of polymer melts on the coextrusion process based on wall slip conditions
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