An application of citric acid as a carrier for solid dispersion to improve the dissolution and uric acid-lowering effect of kaempferol
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Danni Song
und
Xu Zhao
Abstract
Kaempferol (KPF) is a flavonoid compound, which has a variety of pharmacological activities, and widely exists in daily diet. However, its application is limited due to poor solubility. Citric acid (CA) is a common food additive with high solubility. In this study, solid dispersion (SD) was prepared with CA as the carrier to improve the solubility of KPF. KPF-CA-SD (weight ratio 1:20) was obtained by ultrasonic for 20 min at 40 °C. The in vitro dissolution of KPF in SD was increased from about 50% to more than 80%. The physicochemical characterizations were analyzed by X-ray diffraction, differential scanning calorimetry, Fourier transform infrared spectroscopy, and scanning electron microscope. In hyperuricemia mice, KPF-SD (equivalent to 100 mg/kg KPF) can effectively reduce serum uric acid and exert nephroprotective effects. In conclusion, the preparation of SD with CA might provide a safe and effective selection to facilitate application of KPF in food and medicine.
Funding source: Young and Middle Aged Teachers’ Career Development Support Project of Shenyang Pharmaceutical University
Award Identifier / Grant number: ZQN2019005
Funding source: Livelihood Plan Project of Department of Science and Technology of Liaoning Province
Award Identifier / Grant number: 2021JH2/10300069
Funding source: Department of Education of Liaoning Province
Award Identifier / Grant number: LJKZ0918
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Author contributions: Danni Song: Substantial contributions to the conception and design of the work, analyse the data for the work; Changqing Xie, Rong Yang, Aijinxiu Ma, Honghui Zhao: contributions to data acquisition; Fengmao Zou: analyse the data for the work; Xiangrong Zhang and Xu Zhao: co-corresponding authors, who contribute to final approval of the version to be published; and agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
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Research funding: This work was supported by Young and Middle Aged Teachers’ Career Development Support Project of Shenyang Pharmaceutical University (ZQN2019005); Livelihood Plan Project of Department of Science and Technology of Liaoning Province (2021JH2/10300069); Department of Education of Liaoning Province (LJKZ0918).
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Conflict of interest statement: The authors declare that there are no conflicts of interest regarding the publication of this study.
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Supplementary Material
This article contains supplementary material (https://doi.org/10.1515/ijfe-2022-0214).
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Artikel in diesem Heft
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Artikel in diesem Heft
- Frontmatter
- Articles
- Alginate and β-lactoglobulin matrix as wall materials for encapsulation of polyphenols to improve efficiency and stability
- Effect of water-retention agents on Scomberomorus niphonius surimi after repeated freeze–thaw cycles: low-field NMR and MRI studies
- The influences of acidic electrolyzed water on quality and bacteria community of fresh-cut jackfruit in storage
- Dietary modeling of greenhouse gases using OECD meat consumption/retail availability estimates
- An application of citric acid as a carrier for solid dispersion to improve the dissolution and uric acid-lowering effect of kaempferol
- Response to Article
- The properties of potato gluten-free doughs: comparative and combined effects of propylene glycol alginate and hydroxypropyl methyl cellulose or flaxseed gum
