Abstract
In this work, we reported preparation of melatonin-loaded zein nanoparticles using the technique of solution-enhanced dispersion by supercritical CO2 (SEDS) for prolonging the release of melatonin. The influence of pressure, temperature and the ratio of melatonin and zein on the morphology, the particle size and drug loading was investigated. The release profiles of the melatonin-loaded nanoparticles were evaluated. The sizes of the most particles were less than 100 nm at most conditions examined, and the morphology had three types: rod-like, globule, and filament. The maximum drug loading of 6.9% and encapsulation efficiencies of 80.2% were obtained, respectively, under different conditions. The release speed of the melatonin in the nanoparticles is lower than both the pure one and that in the physical mixture. It displayed a near zero-order release which implied that it could be applied as a potential controlled-release drug.
Funding statement: This research was supported by the National Natural Science Foundation of China (20976103).
Acknowledgments
We are thankful to the Instrumental Analysis Center of Shanghai Jiao Tong University for assistance with TEM.
Conflict of Interest: The authors declare that they have no conflict of interest.
References
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© 2017 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Functional and Film-forming Properties of Mechanically Deboned Chicken Meat Proteins
- Development and Evaluation of a Small-scale In-field Integrated Postharvest Citrus Treatment Unit – Part 1
- Unripe Banana Flour Produced by Air-Drying Assisted with Ultrasound – Description of the Mechanisms Involved to Enhance the Mass Transfer in Two Approaches
- Analysis of Operating Conditions on Osmotic Dehydration of Plums (Prunus Domestica L.) and 3D-Numerical Determination of Effective Diffusion Coefficients
- Applying CFD for Studying the Dynamic and Thermal Behavior of Solar Chimney Drying System with Reversed Absorber
- Optimization and In-vitro Evaluation of Coating Process for Film-Coated Tablets
- Drying Kinetics of Continuous and Intermittent Heat Pump Drying of Green Soybean Seeds
- Predicting Storage Conditions for Rice Seed with Thermodynamic Analysis
- Preparation of Melatonin-Loaded Zein Nanoparticles using Supercritical CO2 Antisolvent and in vitro Release Evaluation
- A Simple Method to Prepare Raw Dehydrated Potato Flour by Low-Temperature Vacuum Drying
Articles in the same Issue
- Functional and Film-forming Properties of Mechanically Deboned Chicken Meat Proteins
- Development and Evaluation of a Small-scale In-field Integrated Postharvest Citrus Treatment Unit – Part 1
- Unripe Banana Flour Produced by Air-Drying Assisted with Ultrasound – Description of the Mechanisms Involved to Enhance the Mass Transfer in Two Approaches
- Analysis of Operating Conditions on Osmotic Dehydration of Plums (Prunus Domestica L.) and 3D-Numerical Determination of Effective Diffusion Coefficients
- Applying CFD for Studying the Dynamic and Thermal Behavior of Solar Chimney Drying System with Reversed Absorber
- Optimization and In-vitro Evaluation of Coating Process for Film-Coated Tablets
- Drying Kinetics of Continuous and Intermittent Heat Pump Drying of Green Soybean Seeds
- Predicting Storage Conditions for Rice Seed with Thermodynamic Analysis
- Preparation of Melatonin-Loaded Zein Nanoparticles using Supercritical CO2 Antisolvent and in vitro Release Evaluation
- A Simple Method to Prepare Raw Dehydrated Potato Flour by Low-Temperature Vacuum Drying