Design and Simulation of a Chaotic Micromixer with Diamond-Like Micropillar Based on Artificial Neural Network
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Xueye Chen
und
Jienan Shen
Abstract
Microfluidic mixing is an essential part of the process of microfluidic chip technology in the analysis, and micromixer has also become the key components of microfluidic chip analysis system. For DNA hybridization, protein folding and enzyme reaction, some biochemical processes need to react quickly to achieve on analysis and research has the vital significance. A simple, rapid and low-cost passive micromixer is presented in this paper. In order to improve the mixing efficiency of the species, the concept of a splitting and recombination (SAR) was used to shorten the mixing time of the species. This study simulated the species mixing in a micromixer with traditional T-type micromixer and diamond-like micropillar in laminar flow state through COMSOL multiphysics 3.5a to computational fluid dynamics (CFD). Linking artificial neural network (ANN) and CFD was used to optimize the diamond-like micropillar. Finally, simulation results proved that the micromixer with SAR diamond-like concept achieves a high-efficiency mixing than T-type micromixer. Numerical results also show that the mixing efficiency of the SAR micromixer with diamond-like micropillar can be up to 99 %, and that efficiency can reach rapidly 90 % in a short channel distance.
Acknowledgement
This work was supported by National Natural Science Foundation of China (51405214), Liaoning Province Doctor Startup Fund (20141131), Fund of Liaoning Province Education Administration (L2014241), and the Fund in Liaoning University of Technology (X201301).
References
1. 1. Abdelhay, A., 2002. Application of artificial neural networks to predict the carbon content and the grain size for carbon steels. Egyptian Journal of Solids 25, 229–243.10.21608/ejs.2002.150480Suche in Google Scholar
2. 2. Bessoth, F. G., deMello, A. J., Manz, A., 1999. Microstructure for efficient continuous flow mixing. Analytical Communications 36(6), 213–215.10.1039/a902237fSuche in Google Scholar
3. 3. Bhagat, A. A. S., Peterson, E. T. K., Papautsky, I., 2007. A passive planar micromixer with obstructions for mixing at low Reynolds numbers. Journal of Micromechanics and Microengineering 17, 1017–1024.10.1088/0960-1317/17/5/023Suche in Google Scholar
4. 4. Branebjerg, J., Fabius, B., Gravesen, P., 1994. Application of miniature analyzers: from microfluidic components to μTAS. Proceedings of Micro Total Analysis Systems Conference, Twente, Netherlands, pp. 141–151.10.1007/978-94-011-0161-5_14Suche in Google Scholar
5. 5. Branebjerg, J., Gravesen, P., Krog, J. P., Nielsen, C. R., 1996. Fast mixing by lamination. Proceedings of the IEEE Micro Electro Mechanical Systems. San Diego, USA, pp. 441–446.10.1109/MEMSYS.1996.494022Suche in Google Scholar
6. 6. Chen, H., Meiners, J. C., 2004. Topologic mixing on a microfluidic chip. Applied Physics Letters 84(12), 2193–2195.10.1063/1.1686895Suche in Google Scholar
7. 7. Fujii, T., Hosokawa, K., Shoji, S., Yotsumoto, A., Mojima, T., Endo, I., 1998. Development of a microfabricated biochemical workbench-improving the mixing efficiency. microTAS 1998, pp. 173–176.10.1007/978-94-011-5286-0_42Suche in Google Scholar
8. 8. Hardt, S., Schonfeld, F., 2003. Laminar mixing in different interdigital micromixers: II. Numerical simulations. AIChE Journal 49(3), 578–584.10.1002/aic.690490305Suche in Google Scholar
9. 9. He, B., Burke, B. J., Zhang, X., Zhang, R., Regnier, F. E., 2001. A picoliter-volume mixer for microfluidic analytical systems. Analytical Chemistry 73(9), 1942–1947.10.1021/ac000850xSuche in Google Scholar PubMed
10. 10. Hessel, V., Lowe, H., Schonfeld, F., 2005. Micromixers–a review on passive and active mixing principles. Chemical Engineering Science 60, 2479–2501.10.1016/j.ces.2004.11.033Suche in Google Scholar
11. 11. Hinsmann, P., Frank, J., Svasek, P., Harasek, M., Lendl, B., 2001. Design, simulation and application of a new micromixing device for time resolved infrared spectroscopy of chemical reactions in solutio. Lab Chip 1(1), 16–21.10.1039/b104391aSuche in Google Scholar PubMed
12. 12. Kockmann, N., Kiefer, T., Engler, M., et al., 2006. Convective mixing and chemical reactions in microchannels with high flow rates. Sensors and Actuators B: Chemical 117(2), 495–508.10.1109/SENSOR.2005.1497378Suche in Google Scholar
13. 13. Lee, S., Lee, H.-Y., Lee, I.-F., Tseng, C.-Y., 2004. Ink diffusion in water. European Journal of Physics 25, 331–336.10.1088/0143-0807/25/2/020Suche in Google Scholar
14. 14. Manz, A., Graber, N., Widmer, H. M., 1990. Miniaturized total chemical analysis systems: A novel concept for chemical sensing. Actuators B, 1, 244–248.10.1016/0925-4005(90)80209-ISuche in Google Scholar
15. 15. Manz, A., Harrison, D. J., Verpoorte, E. M. J., Fettinger, J. C., Paulus, A., Ludi, H., Widmer, H. M., 1992. Planar chips technology for miniaturization and integration of separation techniques into monitoring systems – capillary electrophoresis on a chip. Journal of Chromatography A, 593, 253–258.10.1016/0021-9673(92)80293-4Suche in Google Scholar
16. 16. Munson, M. S., Yager, P., 2004. Simple quantitative optical method for monitoring the extent of mixing applied to a novel microfluidic mixer. Analytica Chimica Acta 507(1), 63–71.10.1016/j.aca.2003.11.064Suche in Google Scholar
17. 17. Park, S. J., Kim, J. K., Park, J., Chung, S., Chung, C., Chang, J. K., 2003. Rapid three-dimensional passive rotation micromixer using the breakup process. Journal of Micromechanics and Microengineering 14(1), 6–14.10.1088/0960-1317/14/1/302Suche in Google Scholar
18. 18. Rohr, T., Yu, C., Davey, M. H., Svec, F., Frechet, J. M. J., 2001. Porous polymer monoliths: simple and efficient mixers prepared by direct polymerization in the channels of microfluidic chips. Electrophoresis 22(18), 3959–3967.10.1002/1522-2683(200110)22:18<3959::AID-ELPS3959>3.0.CO;2-5Suche in Google Scholar
19. 19. Schwesinger, N., Frank, T., Wurmus, H., 1996. A modular microfluid system with an integrated micromixer. Journal of Micromechanics and Microengineering 6(1), 99–102.10.1088/0960-1317/6/1/023Suche in Google Scholar
20. 20. Shih, T. R., Chung, C. K., 2008. A high-efficiency planar micromixer with convection and diffusion mixing over a wide Reynolds number range. Microfluidics and Nanofluidics 5(2), 175–183.10.1007/s10404-007-0238-4Suche in Google Scholar
22. 22. Shoji, S., Esashi, M., 1994. Micro flow devices and systems. Journal of Micromechanics and Microengineering 4, 157–171.10.1088/0960-1317/4/4/001Suche in Google Scholar
23. 23. Tran-Minh, N., Karlsen, F., Dong, T., Le-The, H., 2014. A simple and low cost micromixer for laminar blood mixing: design, optimization, and analysis. Biomedical Informatics and Technology, 91–104.10.1007/978-3-642-54121-6_8Suche in Google Scholar
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