Photochemical protein modification in complex biological environments: recent advances and considerations for future chemical methods development
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Michael T. Taylor
Abstract
The development of organic reactions that covalently modify biological matter in complex biological mixtures has become an invaluable asset in drug discovery. Out of the techniques developed to date, optically controlled chemistries are of particular utility owing to both the spatiotemporal control afforded by optical control as well as the impressive array of transformations that are driven by the highly reactive intermediates generated upon excitation. This minireview discusses recent advances in the development of photochemical reactions for use in complex mixtures and highlights key considerations for future photochemical reaction designs.
Funding source: NIGMS funded Sensory Biology COBRE http://dx.doi.org./10.13039/100000057
Award Identifier / Grant number: P20 GM121310
Acknowledgments
We thank the NIGMS-funded Wyoming Sensory Biology COBRE program (P20 GM121310) for support.
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: This review was supported by NIGMS funded Sensory Biology COBRE program (P20 GM121310).
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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© 2022 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Highlight: Chemical Biology in Drug Discovery
- Chemical biology in drug discovery
- Rational approaches towards inorganic and organometallic antibacterials
- Epithelial-mesenchymal transition and H2O2 signaling – a driver of disease progression and a vulnerability in cancers
- Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators
- Artificial metalloenzymes in a nutshell: the quartet for efficient catalysis
- Photochemical protein modification in complex biological environments: recent advances and considerations for future chemical methods development
- Using the yeast three-hybrid system for the identification of small molecule-protein interactions with the example of ethinylestradiol
- Expanded profiling of β-lactam selectivity for penicillin-binding proteins in Streptococcus pneumoniae D39
- Two-photon fluorescent turn-on probes for highly efficient detection and profiling of thiols in live cells and tissues
Artikel in diesem Heft
- Frontmatter
- Highlight: Chemical Biology in Drug Discovery
- Chemical biology in drug discovery
- Rational approaches towards inorganic and organometallic antibacterials
- Epithelial-mesenchymal transition and H2O2 signaling – a driver of disease progression and a vulnerability in cancers
- Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators
- Artificial metalloenzymes in a nutshell: the quartet for efficient catalysis
- Photochemical protein modification in complex biological environments: recent advances and considerations for future chemical methods development
- Using the yeast three-hybrid system for the identification of small molecule-protein interactions with the example of ethinylestradiol
- Expanded profiling of β-lactam selectivity for penicillin-binding proteins in Streptococcus pneumoniae D39
- Two-photon fluorescent turn-on probes for highly efficient detection and profiling of thiols in live cells and tissues
