Abstract
Galanin is a neuropeptide with a widespread distribution throughout the nervous and endocrine systems, and recent studies have shown an anti-proliferative effect of galanin on several types of tumors. However, whether and how galanin and its receptors are involved in the regulation of cell proliferation in glioma cells remains unclear. In this study, the roles of galanin and its subtype 1 receptor (GAL1) in the proliferation of human U251 and T98G glioma cells were investigated. We found that galanin significantly suppressed the proliferation of U251 and T98G cells as well as tumor growth in nude mice. However, galanin did not exert apoptotic or cytotoxic effects on these two cell lines. In addition, we showed that galanin decreased the proliferation of U251 and T98G cells via its GAL1 receptor. Finally, we found that the GAL1 receptor was involved in the suppressive effects of galanin by activating ERK1/2.
Acknowledgments
This work was supported by grants from the National Natural Science Foundation of China (31171032, 31271154, 81671345), the grant from the Beijing Natural Science Foundation (7162016), Beijing Brain Project (Grant Z161100000216142), and the Special Project on Natural Chronic Non-infectious Diseases (2016YFC1307200).
Conflict of interest statement: None to declare.
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Articles in the same Issue
- Frontmatter
- Reviews
- Aeromonas sobria serine protease (ASP): a subtilisin family endopeptidase with multiple virulence activities
- Targeting and inactivation of bacterial toxins by human defensins
- S100A6 – focus on recent developments
- Catalase, a remarkable enzyme: targeting the oldest antioxidant enzyme to find a new cancer treatment approach
- Research Articles/Short Communications
- Protein Structure and Function
- I36T↑T mutation in South African subtype C (C-SA) HIV-1 protease significantly alters protease-drug interactions
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- Mutation of N-linked glycosylation in EpCAM affected cell adhesion in breast cancer cells
- Galanin suppresses proliferation of human U251 and T98G glioma cells via its subtype 1 receptor
- Role of sigma 1 receptor in high fat diet-induced peripheral neuropathy
- Proteolysis
- Tissue kallikrein-related peptidase 4 (KLK4), a novel biomarker in triple-negative breast cancer