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S100A6 – focus on recent developments

  • Wiesława Leśniak , Tomasz Wilanowski und Anna Filipek EMAIL logo
Veröffentlicht/Copyright: 25. März 2017

Abstract

The Ca2+-binding protein, S100A6, belongs to the S100 family. Binding of Ca2+ induces a conformational change, which causes an increase in the overall S100A6 hydrophobicity and allows it to interact with many targets. S100A6 is expressed in different normal tissues and in many tumors. Up to now it has been shown that S100A6 is involved in cell proliferation, cytoskeletal dynamics and tumorigenesis, and that it might have some extracellular functions. In this review, we summarize novel discoveries concerning S100A6 targets, its involvement in cellular signaling pathways, and presence in stem/progenitor cells, extracellular matrix and body fluids of diseased patients.

Acknowledgements

This work was supported by grants from the National Science Centre 2011/03/B/NZ1/00595 to A.F., 2012/05/B/NZ2/02944 to W.L., and by statutory funds from the Nencki Institute of Experimental Biology-PAS.

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Received: 2017-3-3
Accepted: 2017-3-21
Published Online: 2017-3-25
Published in Print: 2017-9-26

©2017 Walter de Gruyter GmbH, Berlin/Boston

Heruntergeladen am 23.9.2025 von https://www.degruyterbrill.com/document/doi/10.1515/hsz-2017-0125/html
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