Startseite Molecular challenges imposed by MHC-I restricted long epitopes on T cell immunity
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Molecular challenges imposed by MHC-I restricted long epitopes on T cell immunity

  • Tracy M. Josephs , Emma J. Grant und Stephanie Gras EMAIL logo
Veröffentlicht/Copyright: 23. Juni 2017
Biological Chemistry
Aus der Zeitschrift Biological Chemistry Band 398 Heft 9

Abstract

It has widely been accepted that major histocompatibility complex class I molecules (MHC-I) are limited to binding small peptides of 8–10 residues in length. However, this consensus has recently been challenged with the identification of longer peptides (≥11 residues) that can also elicit cytotoxic CD8+ T cell responses. Indeed, a growing number of studies demonstrate that these non-canonical epitopes are important targets for the immune system. As long epitopes represent up to 10% of the peptide repertoire bound to MHC-I molecules, here we review their impact on antigen presentation by MHC-I, TCR recognition, and T cell immunity.

Keywords: antigen presentation; human leukocyte antigen; major histocompatibility complex; T cell receptor recognition; tumor peptide; viral peptide

Acknowledgements

This work has been supported by the Australian Research Council and the National Health and Medical Research Council. E.J.G. was supported by an NHMRC CJ Martin Early Career Fellowship and S.G. was supported by an ARC Future Fellowship (FT120100416).

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Received: 2016-10-10
Accepted: 2017-1-25
Published Online: 2017-6-23
Published in Print: 2017-8-28

©2017 Walter de Gruyter GmbH, Berlin/Boston

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  2. Reviews
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  9. Research Articles/Short Communications
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https://doi.org/10.1515/hsz-2016-0305
Schlagwörter für diesen Artikel
antigen presentation; human leukocyte antigen; major histocompatibility complex; T cell receptor recognition; tumor peptide; viral peptide

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. The role of sirtuins in mitochondrial function and doxorubicin-induced cardiac dysfunction
  4. Structural and functional insight into pan-endopeptidase inhibition by α2-macroglobulins
  5. Iron overload and altered iron metabolism in ovarian cancer
  6. Shared function and moonlighting proteins in molybdenum cofactor biosynthesis
  7. Minireview
  8. Molecular challenges imposed by MHC-I restricted long epitopes on T cell immunity
  9. Research Articles/Short Communications
  10. Protein Structure and Function
  11. The monoheme cytochrome c subunit of Alternative Complex III is a direct electron donor to caa3 oxygen reductase in Rhodothermus marinus
  12. Cell Biology and Signaling
  13. β-NGF and β-NGF receptor upregulation in blood and synovial fluid in osteoarthritis
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