Abstract
Epithelial barriers play an important role in regulating mucosal homeostasis. Upon injury, the epithelium and immune cells orchestrate repair mechanisms that re-establish homeostasis. This process is highly regulated by protein and lipid mediators such as Annexin A1 (ANXA1). In this review, we focus on the pro-repair properties of ANXA1.
References
Aalberts, M., van Dissel-Emiliani, F.M., van Adrichem, N.P., van Wijnen, M., Wauben, M.H., Stout, T.A., and Stoorvogel, W. (2012). Identification of distinct populations of prostasomes that differentially express prostate stem cell antigen, annexin A1, and GLIPR2 in humans. Biol. Reprod. 86, 82.10.1095/biolreprod.111.095760Search in Google Scholar PubMed
Alam, A., Leoni, G., Wentworth, C.C., Kwal, J.M., Wu, H., Ardita, C.S., Swanson, P.A., Lambeth, J.D., Jones, R.M., Nusrat, A., et al. (2014). Redox signaling regulates commensal-mediated mucosal homeostasis and restitution and requires formyl peptide receptor 1. Mucosal Immunol. 7, 645–655.10.1038/mi.2013.84Search in Google Scholar PubMed PubMed Central
Alam, A., Leoni, G., Quiros, M., Wu, H., Desai, C., Nishio, H., Jones, R.M., Nusrat, A., and Neish, A.S. (2016). The microenvironment of injured murine gut elicits a local pro-restitutive microbiota. Nat Microbiol 1, 15021.10.1038/nmicrobiol.2015.21Search in Google Scholar PubMed PubMed Central
Babbin, B.A., Lee, W.Y., Parkos, C.A., Winfree, L.M., Akyildiz, A., Perretti, M., and Nusrat, A. (2006). Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptide receptors. J. Biol. Chem. 281, 19588–19599.10.1074/jbc.M513025200Search in Google Scholar PubMed
Babbin, B.A., Jesaitis, A.J., Ivanov, A.I., Kelly, D., Laukoetter, M., Nava, P., Parkos, C.A., and Nusrat, A. (2007). Formyl peptide receptor-1 activation enhances intestinal epithelial cell restitution through phosphatidylinositol 3-kinase-dependent activation of Rac1 and Cdc42. J. Immunol. 179, 8112–8121.10.4049/jimmunol.179.12.8112Search in Google Scholar PubMed
Babbin, B.A., Laukoetter, M.G., Nava, P., Koch, S., Lee, W.Y., Capaldo, C.T., Peatman, E., Severson, E.A., Flower, R.J., Perretti, M., et al. (2008). Annexin A1 regulates intestinal mucosal injury, inflammation, and repair. J. Immunol. 181, 5035–5044.10.4049/jimmunol.181.7.5035Search in Google Scholar PubMed PubMed Central
Basil, M.C. and Levy, B.D. (2016). Specialized pro-resolving mediators: endogenous regulators of infection and inflammation. Nat. Rev. Immunol. 16, 51–67.10.1038/nri.2015.4Search in Google Scholar PubMed PubMed Central
Blume, K.E., Soeroes, S., Keppeler, H., Stevanovic, S., Kretschmer, D., Rautenberg, M., Wesselborg, S., and Lauber, K. (2012). Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic "find-me" signal. J. immunol. 188, 135–145.10.4049/jimmunol.1004073Search in Google Scholar PubMed
Boudhraa, Z., Bouchon, B., Viallard, C., D’Incan, M., and Degoul, F. (2016). Annexin A1 localization and its relevance to cancer. Clin. Sci. 130, 205–220.10.1042/CS20150415Search in Google Scholar PubMed
Brancaleone, V., Mitidieri, E., Flower, R.J., Cirino, G., and Perretti, M. (2014). Annexin A1 mediates hydrogen sulfide properties in the control of inflammation. J. Pharmacol. Exp. Ther. 351, 96–104.10.1124/jpet.114.217034Search in Google Scholar PubMed PubMed Central
Buckley, C.D., Gilroy, D.W., and Serhan, C.N. (2014). Proresolving lipid mediators and mechanisms in the resolution of acute inflammation. Immunity 40, 315–327.10.1016/j.immuni.2014.02.009Search in Google Scholar
Chatterjee, B.E., Yona, S., Rosignoli, G., Young, R.E., Nourshargh, S., Flower, R.J., and Perretti, M. (2005). Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. J. Leukoc. Biol. 78, 639–646.10.1189/jlb.0405206Search in Google Scholar
Cooray, S.N., Gobbetti, T., Montero-Melendez, T., McArthur, S., Thompson, D., Clark, A.J., Flower, R.J., and Perretti, M. (2013). Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses. Proc. Natl. Acad. Sci. USA 110, 18232–18237.10.1073/pnas.1308253110Search in Google Scholar
Cosnes, J., Gower-Rousseau, C., Seksik, P., and Cortot, A. (2011). Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology 140, 1785–1794.10.1053/j.gastro.2011.01.055Search in Google Scholar
Cristante, E., McArthur, S., Mauro, C., Maggioli, E., Romero, I.A., Wylezinska-Arridge, M., Couraud, P.O., Lopez-Tremoleda, J., Christian, H.C., Weksler, B.B., et al. (2013). Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications. Proc. Natl. Acad. Sci. USA 110, 832–841.10.1073/pnas.1209362110Search in Google Scholar
Croxtall, J.D. and Flower, R.J. (1994). Antisense oligonucleotides to human lipocortin-1 inhibit glucocorticoid-induced inhibition of A549 cell growth and eicosanoid release. Biochem. Pharmacol. 48, 1729–1734.10.1016/0006-2952(94)90458-8Search in Google Scholar
Dalli, J., Norling, L.V., Renshaw, D., Cooper, D., Leung, K.Y., and Perretti, M. (2008). Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. Blood 112, 2512–2519.10.1182/blood-2008-02-140533Search in Google Scholar PubMed
Dalli, J., Jones, C.P., Cavalcanti, D.M., Farsky, S.H., Perretti, M., and Rankin, S.M. (2012). Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow. FASEB J. 26, 387–396.10.1096/fj.11-182089Search in Google Scholar PubMed PubMed Central
Damazo, A.S., Sampaio, A.L., Nakata, C.M., Flower, R.J., Perretti, M., and Oliani, S.M. (2011). Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis. BMC Immunol. 12, 59.10.1186/1471-2172-12-59Search in Google Scholar PubMed PubMed Central
de Graauw, M., van Miltenburg, M.H., Schmidt, M.K., Pont, C., Lalai, R., Kartopawiro, J., Pardali, E., Le Devedec, S.E., Smit, V.T., van der Wal, A., et al. (2010). Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells. Proc. Natl. Acad. Sei. USA 107, 6340–6345.10.1073/pnas.0913360107Search in Google Scholar PubMed PubMed Central
de Torre-Minguela, C., Barbera-Cremades, M., Gomez, A.I., Martin-Sanchez, F., and Pelegrin, P. (2016). Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process. Sci. Rep. 6, 22586.10.1038/srep22586Search in Google Scholar
Del Gaudio, P., De Cicco, F., Aquino, R.P., Picerno, P., Russo, P., Dal Piaz, F., Bizzarro, V., Belvedere, R., Parente, L., and Petrella, A. (2015). Evaluation of in situ injectable hydrogels as controlled release device for ANXA1 derived peptide in wound healing. Carbohydr. Polym. 115, 629–635.10.1016/j.carbpol.2014.09.040Search in Google Scholar
Drechsler, M., de Jong, R., Rossaint, J., Viola, J.R., Leoni, G., Wang, J.M., Grommes, J., Hinkel, R., Kupatt, C., Weber, C., et al. (2015). Annexin A1 counteracts chemokine-induced arterial myeloid cell recruitment. Circ. Res. 116, 827–835.10.1161/CIRCRESAHA.116.305825Search in Google Scholar
Euzger, H.S., Flower, R.J., Goulding, N.J., and Perretti, M. (1999). Differential modulation of annexin I binding sites on monocytes and neutrophils. Mediators Inflamm. 8, 53–62.10.1080/09629359990720Search in Google Scholar
Flower, R.J., and Rothwell, N.J. (1994). Lipocortin-1: cellular mechanisms and clinical relevance. Trends Pharmacol. Sci. 15, 71–76.10.1016/0165-6147(94)90281-XSearch in Google Scholar
Fredman, G., Kamaly, N., Spolitu, S., Milton, J., Ghorpade, D., Chiasson, R., Kuriakose, G., Perretti, M., Farokhzad, O., and Tabas, I. (2015). Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice. Sci. Transl. Med. 7, 275ra220.10.1126/scitranslmed.aaa1065Search in Google Scholar PubMed PubMed Central
Fullerton, J.N. and Gilroy, D.W. (2016). Resolution of inflammation: a new therapeutic frontier. Nat Rev Drug Discov.10.1038/nrd.2016.39Search in Google Scholar PubMed
Gastardelo, T.S., Cunha, B.R., Raposo, L.S., Maniglia, J.V., Cury, P.M., Lisoni, F.C., Tajara, E.H., and Oliani, S.M. (2014). Inflammation and cancer: role of annexin A1 and FPR2/ALX in proliferation and metastasis in human laryngeal squamous cell carcinoma. PLoS One 9, e111317.10.1371/journal.pone.0111317Search in Google Scholar PubMed PubMed Central
Gavins, F.N. and Hickey, M.J. (2012). Annexin A1 and the regulation of innate and adaptive immunity. Front Immunol. 3, 354.10.3389/fimmu.2012.00354Search in Google Scholar PubMed PubMed Central
Getting, S.J., Flower, R.J., and Perretti, M. (1997). Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1. Br. J. Pharmacol. 120, 1075–1082.10.1038/sj.bjp.0701029Search in Google Scholar PubMed PubMed Central
Goto-Inoue, N., Tamura, K., Motai, F., Ito, M., Miyata, K., Manabe, Y., and Fujii, N.L. (2016). A fragmented form of annexin A1 is secreted from C2C12 myotubes by electric pulse-induced contraction. Mol. Cell. Biochem. 411, 173–180.10.1007/s11010-015-2579-8Search in Google Scholar
Goulding, N.J., Pan, L., Wardwell, K., Guyre, V.C., and Guyre, P.M. (1996). Evidence for specific annexin I-binding proteins on human monocytes. Biochem. J. 316, 593–597.10.1042/bj3160593Search in Google Scholar
Hayhoe, R.P., Kamal, A.M., Solito, E., Flower, R.J., Cooper, D., and Perretti, M. (2006). Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement. Blood 107, 2123–2130.10.1182/blood-2005-08-3099Search in Google Scholar
Headland, S.E. and Norling, L.V. (2015). The resolution of inflammation: principles and challenges. Semin. Immunol. 27, 149–160.10.1016/j.smim.2015.03.014Search in Google Scholar
Headland, S.E., Jones, H.R., Norling, L.V., Kim, A., Souza, P.R., Corsiero, E., Gil, C.D., Nerviani, A., Dell’Accio, F., Pitzalis, C., et al. (2015). Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. Sci. Transl. Med. 7, 315ra190.10.1126/scitranslmed.aac5608Search in Google Scholar
Kusters, D.H., Chatrou, M.L., Willems, B.A., De Saint-Hubert, M., Bauwens, M., van der Vorst, E., Bena, S., Biessen, E.A., Perretti, M., Schurgers, L.J., et al. (2015). Pharmacological treatment with annexin A1 reduces atherosclerotic plaque burden in LDLR-/- mice on Western type diet. PLoS One 10, e0130484.10.1371/journal.pone.0130484Search in Google Scholar
Le, Y., Murphy, P.M., and Wang, J.M. (2002). Formyl-peptide receptors revisited. Trends Immunol. 23, 541–548.10.1016/S1471-4906(02)02316-5Search in Google Scholar
Leikina, E., Defour, A., Melikov, K., Van der Meulen, J.H., Nagaraju, K., Bhuvanendran, S., Gebert, C., Pfeifer, K., Chernomordik, L.V., and Jaiswal, J.K. (2015). Annexin A1 deficiency does not affect myofiber repair but delays regeneration of injured muscles. Sci. Rep. 5, 18246.10.1038/srep18246Search in Google Scholar PubMed PubMed Central
Leoni, G., Alam, A., Neumann, P.A., Lambeth, J.D., Cheng, G., McCoy, J., Hilgarth, R.S., Kundu, K., Murthy, N., Kusters, D., et al. (2013). Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J. Clin. Invest. 123, 443–454.10.1172/JCI65831Search in Google Scholar PubMed PubMed Central
Leoni, G., Gripentrog, J., Lord, C., Riesselman, M., Sumagin, R., Parkos, C.A., Nusrat, A., and Jesaitis, A.J. (2015a). Human neutrophil formyl peptide receptor phosphorylation and the mucosal inflammatory response. J. Leukoc. Biol. 97, 87–101.10.1189/jlb.4A0314-153RSearch in Google Scholar PubMed PubMed Central
Leoni, G., Neumann, P.A., Kamaly, N., Quiros, M., Nishio, H., Jones, H.R., Sumagin, R., Hilgarth, R.S., Alam, A., Fredman, G., et al. (2015b). Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J. Clin. Invest. 125, 1215–1227.10.1172/JCI76693Search in Google Scholar PubMed PubMed Central
Leoni, G., Neumann, P.A., Sumagin, R., Denning, T.L., and Nusrat, A. (2015c). Wound repair: role of immune-epithelial interactions. Mucosal Immunol. 8, 959–968.10.1038/mi.2015.63Search in Google Scholar PubMed PubMed Central
Li, Y., Cai, L., Wang, H., Wu, P., Gu, W., Chen, Y., Hao, H., Tang, K., Yi, P., Liu, M., et al. (2011). Pleiotropic regulation of macrophage polarization and tumorigenesis by formyl peptide receptor-2. Oncogene 30, 3887–3899.10.1038/onc.2011.112Search in Google Scholar PubMed
Lin, C.Y., Jeng, Y.M., Chou, H.Y., Hsu, H.C., Yuan, R.H., Chiang, C.P., and Kuo, M.Y. (2008). Nuclear localization of annexin A1 is a prognostic factor in oral squamous cell carcinoma. J. Surg. Oncol. 97, 544–550.10.1002/jso.20992Search in Google Scholar PubMed
Locatelli, I., Sutti, S., Jindal, A., Vacchiano, M., Bozzola, C., Reutelingsperger, C., Kusters, D., Bena, S., Parola, M., Paternostro, C., et al. (2014). Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice. Hepatology 60, 531–544.10.1002/hep.27141Search in Google Scholar PubMed PubMed Central
Maderna, P., Yona, S., Perretti, M., and Godson, C. (2005). Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide Ac(2-26). J. Immunol. 174, 3727–3733.10.4049/jimmunol.174.6.3727Search in Google Scholar PubMed
Mancuso, F., Flower, R.J., and Perretti, M. (1995). Leukocyte transmigration, but not rolling or adhesion, is selectively inhibited by dexamethasone in the hamster post-capillary venule. Involvement of endogenous lipocortin 1. J. immunol. 155, 377–386.10.4049/jimmunol.155.1.377Search in Google Scholar
McArthur, S., Gobbetti, T., Kusters, D.H., Reutelingsperger, C.P., Flower, R.J., and Perretti, M. (2015). Definition of a novel pathway centered on lysophosphatidic acid to recruit monocytes during the resolution phase of tissue inflammation. J. Immunol. 195, 1139–1151.10.4049/jimmunol.1500733Search in Google Scholar PubMed PubMed Central
Morand, E.F., Hall, P., Hutchinson, P., and Yang, Y.H. (2006). Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. Mediators Inflamm. 2006, 73835.10.1155/MI/2006/73835Search in Google Scholar PubMed PubMed Central
Murav’ev, R.A., Fomina, V.A., and Rogovin, V.V. (2003). [Gelatinase granules of the neutrophil granulocytes]. Izv. Akad. Nauk Ser. Biol. 30, 389–394.Search in Google Scholar
Neymeyer, H., Labes, R., Reverte, V., Saez, F., Stroh, T., Dathe, C., Hohberger, S., Zeisberg, M., Muller, G.A., Salazar, J., et al. (2015). Activation of annexin A1 signalling in renal fibroblasts exerts antifibrotic effects. Acta Physiol 215, 144–158.10.1111/apha.12586Search in Google Scholar PubMed
Oh, P., Testa, J.E., Borgstrom, P., Witkiewicz, H., Li, Y., and Schnitzer, J.E. (2014). In vivo proteomic imaging analysis of caveolae reveals pumping system to penetrate solid tumors. Nat. Med. 20, 1062–1068.10.1038/nm.3623Search in Google Scholar PubMed
Ortega-Gomez, A., Perretti, M., and Soehnlein, O. (2013). Resolution of inflammation: an integrated view. EMBO Mol. Med. 5, 661–674.10.1002/emmm.201202382Search in Google Scholar PubMed PubMed Central
Ouyang, N., Zhu, C., Zhou, D., Nie, T., Go, M.F., Richards, R.J., and Rigas, B. (2012). MC-12, an annexin A1-based peptide, is effective in the treatment of experimental colitis. PLoS One 7, e41585.10.1371/journal.pone.0041585Search in Google Scholar PubMed PubMed Central
Pederzoli-Ribeil, M., Maione, F., Cooper, D., Al-Kashi, A., Dalli, J., Perretti, M., and D’Acquisto, F. (2010). Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculature. Blood 116, 4288–4296.10.1182/blood-2010-02-270520Search in Google Scholar PubMed
Perretti, M. (2003). The annexin 1 receptor(s): is the plot unravelling? Trends Pharmacol. Sci. 24, 574–579.10.1016/j.tips.2003.09.010Search in Google Scholar PubMed
Perretti, M., and D’Acquisto, F. (2009). Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. Nat. Rev. Immunol. 9, 62–70.10.1038/nri2470Search in Google Scholar PubMed
Perretti, M., Ahluwalia, A., Harris, J.G., Harris, H.J., Wheller, S.K., and Flower, R.J. (1996). Acute inflammatory response in the mouse: exacerbation by immunoneutralization of lipocortin 1. Br. J. Pharmacol. 117, 1145–1154.10.1111/j.1476-5381.1996.tb16709.xSearch in Google Scholar PubMed PubMed Central
Perretti, M., Chiang, N., La, M., Fierro, I.M., Marullo, S., Getting, S.J., Solito, E., and Serhan, C.N. (2002). Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nat. Med. 8, 1296–1302.10.1038/nm786Search in Google Scholar PubMed PubMed Central
Perretti, M., Christian, H., Wheller, S.K., Aiello, I., Mugridge, K.G., Morris, J.F., Flower, R.J., and Goulding, N.J. (2000). Annexin I is stored within gelatinase granules of human neutrophil and mobilized on the cell surface upon adhesion but not phagocytosis. Cell. Biol. Int. 24, 163–174.10.1006/cbir.1999.0468Search in Google Scholar PubMed
Pin, A.L., Houle, F., Fournier, P., Guillonneau, M., Paquet, E.R., Simard, M.J., Royal, I., and Huot, J. (2012). Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression. J. Biol. Chem. 287, 30541–30551.10.1074/jbc.M112.393561Search in Google Scholar PubMed PubMed Central
Planaguma, A., Kazani, S., Marigowda, G., Haworth, O., Mariani, T.J., Israel, E., Bleecker, E.R., Curran-Everett, D., Erzurum, S.C., Calhoun, W.J., et al. (2008). Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma. Am. J. Respir. Crit. Care Med. 178, 574–582.10.1164/rccm.200801-061OCSearch in Google Scholar PubMed PubMed Central
Raposo, G. and Stoorvogel, W. (2013). Extracellular vesicles: exosomes, microvesicles, and friends. J. Cell. Biol. 200, 373–383.10.1083/jcb.201211138Search in Google Scholar PubMed PubMed Central
Riesselman, M., Miettinen, H.M., Gripentrog, J.M., Lord, C.I., Mumey, B., Dratz, E.A., Stie, J., Taylor, R.M., and Jesaitis, A.J. (2007). C-terminal tail phosphorylation of N-formyl peptide receptor: differential recognition of two neutrophil chemoattractant receptors by monoclonal antibodies NFPR1 and NFPR2. J. Immunol. 179, 2520–2531.10.4049/jimmunol.179.4.2520Search in Google Scholar PubMed
Rossi, A.F., Duarte, M.C., Poltronieri, A.B., Valsechi, M.C., Jorge, Y.C., de-Santi Neto, D., Rahal, P., Oliani, S.M., and Silva, A.E. (2014). Deregulation of annexin-A1 and galectin-1 expression in precancerous gastric lesions: intestinal metaplasia and gastric ulcer. Mediators Inflamm. 2014, 478138.10.1155/2014/478138Search in Google Scholar PubMed PubMed Central
Sena, A.A., Pedrotti, L.P., Barrios, B.E., Cejas, H., Balderramo, D., Diller, A., and Correa, S.G. (2015). Lack of TNFRI signaling enhances annexin A1 biological activity in intestinal inflammation. Biochem. Pharmacol. 98, 422–431.10.1016/j.bcp.2015.09.009Search in Google Scholar PubMed
Serhan, C.N. (2014). Pro-resolving lipid mediators are leads for resolution physiology. Nature 510, 92–101.10.1038/nature13479Search in Google Scholar PubMed PubMed Central
Sinniah, A., Yazid, S., Perretti, M., Solito, E., and Flower, R.J. (2016). The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil. Int. Immunopharmacol. 32, 87–95.10.1016/j.intimp.2016.01.003Search in Google Scholar PubMed PubMed Central
Solito, E., Mulla, A., Morris, J.F., Christian, H.C., Flower, R.J., and Buckingham, J.C. (2003). Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin 1 in a human folliculostellate cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase C, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase. Endocrinology 144, 1164–1174.10.1210/en.2002-220592Search in Google Scholar PubMed
Tagoe, C.E., Marjanovic, N., Park, J.Y., Chan, E.S., Abeles, A.M., Attur, M., Abramson, S.B., and Pillinger, M.H. (2008). Annexin-1 mediates TNF-α-stimulated matrix metalloproteinase secretion from rheumatoid arthritis synovial fibroblasts. J. Immunol. 181, 2813–2820.10.4049/jimmunol.181.4.2813Search in Google Scholar PubMed
Taylor, A.D., Loxley, H.D., Flower, R.J., and Buckingham, J.C. (1994). The role of lipocortin 1 (LC1) in the steroid feedback control of hypothalamo-pituitary-adrenocortical function. In vivo studies. Ann. NY Acad. Sci. 746, 446–448.10.1111/j.1749-6632.1994.tb39281.xSearch in Google Scholar PubMed
Trentin, P.G., Ferreira, T.P., Arantes, A.C., Ciambarella, B.T., Cordeiro, R.S., Flower, R.J., Perretti, M., Martins, M.A., and Silva, P.M. (2015). Annexin A1 mimetic peptide controls the inflammatory and fibrotic effects of silica particles in mice. Br. J. Pharmacol. 172, 3058–3071.10.1111/bph.13109Search in Google Scholar PubMed PubMed Central
Tzelepis, F., Verway, M., Daoud, J., Gillard, J., Hassani-Ardakani, K., Dunn, J., Downey, J., Gentile, M.E., Jaworska, J., Sanchez, A.M., et al. (2015). Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection. J. Clin. Invest. 125, 752–768.10.1172/JCI77014Search in Google Scholar PubMed PubMed Central
Vacchelli, E., Ma, Y., Baracco, E.E., Sistigu, A., Enot, D.P., Pietrocola, F., Yang, H., Adjemian, S., Chaba, K., Semeraro, M., et al. (2015). Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1. Science 350, 972–978.10.1126/science.aad0779Search in Google Scholar PubMed
Vago, J.P., Tavares, L.P., Sugimoto, M.A., Lima, G.L., Galvao, I., de Caux, T.R., Lima, K.M., Ribeiro, A.L., Carneiro, F.S., Nunes, F.F., et al. (2016). Proresolving actions of synthetic and natural protease inhibitors are mediated by Annexin A1. J. Immunol. 196, 1922–1932.10.4049/jimmunol.1500886Search in Google Scholar PubMed
Vergnolle, N., Pages, P., Guimbaud, R., Chaussade, S., Bueno, L., Escourrou, J., and Comera, C. (2004). Annexin 1 is secreted in situ during ulcerative colitis in humans. Inflamm. Bowel. Dis. 10, 584–592.10.1097/00054725-200409000-00013Search in Google Scholar PubMed
Vong, L., Ferraz, J.G., Dufton, N., Panaccione, R., Beck, P.L., Sherman, P.M., Perretti, M., and Wallace, J.L. (2012). Up-regulation of Annexin-A1 and lipoxin A(4) in individuals with ulcerative colitis may promote mucosal homeostasis. PLoS One 7, e39244.10.1371/journal.pone.0039244Search in Google Scholar PubMed PubMed Central
Wang, X., Zhu, M., Hjorth, E., Cortes-Toro, V., Eyjolfsdottir, H., Graff, C., Nennesmo, I., Palmblad, J., Eriksdotter, M., Sambamurti, K., et al. (2015). Resolution of inflammation is altered in Alzheimer’s disease. Alzheimers Dement. 11, 40–50. e41–42.10.1016/j.jalz.2013.12.024Search in Google Scholar PubMed PubMed Central
Wentworth, C.C., Jones, R.M., Kwon, Y.M., Nusrat, A., and Neish, A.S. (2010). Commensal-epithelial signaling mediated via formyl peptide receptors. Am. J. Pathol. 177, 2782–2790.10.2353/ajpath.2010.100529Search in Google Scholar PubMed PubMed Central
Wentworth, C.C., Alam, A., Jones, R.M., Nusrat, A., and Neish, A.S. (2011). Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3. J. Biol. Chem. 286, 38448–38455.10.1074/jbc.M111.268938Search in Google Scholar PubMed PubMed Central
Yazid, S., Gardner, P.J., Carvalho, L., Chu, C.J., Flower, R.J., Solito, E., Lee, R.W., Ali, R.R., and Dick, A.D. (2015). Annexin-A1 restricts Th17 cells and attenuates the severity of autoimmune disease. J. Autoimmun. 58, 1–11.10.1016/j.jaut.2014.12.004Search in Google Scholar PubMed
Yazid, S., Leoni, G., Getting, S.J., Cooper, D., Solito, E., Perretti, M., and Flower, R.J. (2010). Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization. Arteriosclerosis Thromb. Vasc. Biol. 30, 1718–1724.10.1161/ATVBAHA.110.209536Search in Google Scholar PubMed PubMed Central
Ye, R.D., Boulay, F., Wang, J.M., Dahlgren, C., Gerard, C., Parmentier, M., Serhan, C.N., and Murphy, P.M. (2009). International union of basic and clinical pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family. Pharmacol. Rev. 61, 119–161.10.1124/pr.109.001578Search in Google Scholar PubMed PubMed Central
Yona, S., Heinsbroek, S.E., Peiser, L., Gordon, S., Perretti, M., and Flower, R.J. (2006). Impaired phagocytic mechanism in annexin 1 null macrophages. Br. J. Pharmacol. 148, 469–477.10.1038/sj.bjp.0706730Search in Google Scholar PubMed PubMed Central
Zanardo, R.C., Perretti, M., and Wallace, J.L. (2005). Annexin-1 is an endogenous gastroprotective factor against indomethacin-induced damage. Am. J. Physiol. Gastrointest Liver Physiol 288, G481–G486.10.1152/ajpgi.00299.2004Search in Google Scholar PubMed
Zhang, M.Z., Yao, B., Yang, S., Jiang, L., Wang, S., Fan, X., Yin, H., Wong, K., Miyazawa, T., Chen, J., et al. (2012). CSF-1 signaling mediates recovery from acute kidney injury. J. Clin. Invest. 122, 4519–4532.10.1172/JCI60363Search in Google Scholar PubMed PubMed Central
Zitvogel, L. and Kroemer, G. (2015). Cancer: antibodies regulate antitumour immunity. Nature 521, 35–37.10.1038/nature14388Search in Google Scholar PubMed
Zitvogel, L., Galluzzi, L., Viaud, S., Vetizou, M., Daillere, R., Merad, M., and Kroemer, G. (2015). Cancer and the gut microbiota: an unexpected link. Sci. Transl. Med. 7, 271ps271.10.1126/scitranslmed.3010473Search in Google Scholar PubMed PubMed Central
©2016 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Guest Editorial
- Highlight: annexins in health and disease
- HIGHLIGHT: ANNEXINS IN HEALTH AND DISEASE
- Emerging functions as host cell factors – an encyclopedia of annexin-pathogen interactions
- Annexins in plasma membrane repair
- Annexin A1: shifting the balance towards resolution and repair
- Annexin A1 and resolution of inflammation: tissue repairing properties and signalling signature
- Annexins A2 and A8 in endothelial cell exocytosis and the control of vascular homeostasis
- The annexin A2 system and angiogenesis
- More than just innate affairs – on the role of annexins in adaptive immunity
- Annexins – insights from knockout mice
- Review
- Regulation of Rap GTPases in mammalian neurons
- Research Articles/Short Communications
- Protein Structure and Function
- Insights into K-Ras 4B regulation by post-translational lysine acetylation
- Cell Biology and Signaling
- MicroRNA-544 down-regulates both Bcl6 and Stat3 to inhibit tumor growth of human triple negative breast cancer
Articles in the same Issue
- Frontmatter
- Guest Editorial
- Highlight: annexins in health and disease
- HIGHLIGHT: ANNEXINS IN HEALTH AND DISEASE
- Emerging functions as host cell factors – an encyclopedia of annexin-pathogen interactions
- Annexins in plasma membrane repair
- Annexin A1: shifting the balance towards resolution and repair
- Annexin A1 and resolution of inflammation: tissue repairing properties and signalling signature
- Annexins A2 and A8 in endothelial cell exocytosis and the control of vascular homeostasis
- The annexin A2 system and angiogenesis
- More than just innate affairs – on the role of annexins in adaptive immunity
- Annexins – insights from knockout mice
- Review
- Regulation of Rap GTPases in mammalian neurons
- Research Articles/Short Communications
- Protein Structure and Function
- Insights into K-Ras 4B regulation by post-translational lysine acetylation
- Cell Biology and Signaling
- MicroRNA-544 down-regulates both Bcl6 and Stat3 to inhibit tumor growth of human triple negative breast cancer