Abstract
Sterile alpha motif and histidine-aspartate domain containing protein 1 (SAMHD1) is a triphosphohydrolase that catalyzes the conversion of deoxyribonucleoside triphosphate to deoxyribonucleoside and triphosphate. SAMHD1 has been a recent focus of study since it was identified as a potent human immunodeficiency virus-1 (HIV-1) restriction factor in the intrinsic antiviral immune system. Recent biochemical and biological studies have suggested that SAMHD1 restricts HIV-1 infection in non-cycling cells by limiting the pool of deoxyribonucleoside triphosphates, thereby interfering with HIV-1 reverse transcription. SAMHD1 also possesses single-stranded DNA and RNA binding activity, with reported nuclease activity, conferring additional HIV-1 restriction function. This review summarizes current knowledge regarding the structure of SAMHD1 and the regulation of its function in HIV-1 restriction.
Acknowledgments
The author thanks Dr. Teresa Brosenitsch for editorial help. This work was supported, in whole or in part, by the National Institutes of Health, grant GM116642 to Jinwoo Ahn. The author apologizes to researchers whose work has not been cited due to limitation of citation allowed in the minireview.
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©2016 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Guest Editorial
- Highlight: Kinin 2015 at São Paulo, Brazil
- Kinin 2015 – International Meeting on Kinin System and Peptide Receptors
- Kinins and microglial responses in bipolar disorder: a neuroinflammation hypothesis
- Kinins and peptide receptors
- The role of N-terminal and C-terminal Arg residues from BK on interaction with kinin B2 receptor
- Genetic analysis of hereditary angioedema in a Brazilian family by targeted next generation sequencing
- Cellular localisation of the kinin B1R in the pancreas of streptozotocin-treated rat and the anti-diabetic effect of the antagonist SSR240612
- New mutations in SERPING1 gene of Brazilian patients with hereditary angioedema
- Differential effect of intranasally administrated kinin B1 and B2 receptor antagonists in Alzheimer’s disease mice
- Kinin B1 receptor mediates memory impairment in the rat hippocampus
- Safety and pharmacokinetics of a kinin B1 receptor peptide agonist produced with different counter-ions
- Minireview
- Functional organization of human SAMHD1 and mechanisms of HIV-1 restriction
- Corrigendum
- Corrigendum to: Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis
Artikel in diesem Heft
- Frontmatter
- Guest Editorial
- Highlight: Kinin 2015 at São Paulo, Brazil
- Kinin 2015 – International Meeting on Kinin System and Peptide Receptors
- Kinins and microglial responses in bipolar disorder: a neuroinflammation hypothesis
- Kinins and peptide receptors
- The role of N-terminal and C-terminal Arg residues from BK on interaction with kinin B2 receptor
- Genetic analysis of hereditary angioedema in a Brazilian family by targeted next generation sequencing
- Cellular localisation of the kinin B1R in the pancreas of streptozotocin-treated rat and the anti-diabetic effect of the antagonist SSR240612
- New mutations in SERPING1 gene of Brazilian patients with hereditary angioedema
- Differential effect of intranasally administrated kinin B1 and B2 receptor antagonists in Alzheimer’s disease mice
- Kinin B1 receptor mediates memory impairment in the rat hippocampus
- Safety and pharmacokinetics of a kinin B1 receptor peptide agonist produced with different counter-ions
- Minireview
- Functional organization of human SAMHD1 and mechanisms of HIV-1 restriction
- Corrigendum
- Corrigendum to: Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis