Abstract
This paper is divided into two sections: the first contains the essential elements of the opening lecture presented by Pr. Regoli to the 2015 International Kinin Symposium in S. Paulo, Brazil on June 28th and the second is the celebration of Dr. Regoli’s 60 years of research on vasoactive peptides. The cardiovascular homeostasis derives from a balance of two systems, the renin-angiotensin system (RAS) and the kallikrein-kinin system (KKS). The biologically active effector entity of RAS is angiotensin receptor-1 (AT-1R), and that of KKS is bradykinin B2 receptor (B2R). The first mediates vasoconstriction, the second is the most potent and efficient vasodilator. Thanks to its complex and multi-functional mechanism of action, involving nitric oxide (NO), prostacyclin and endothelial hyperpolarizing factor (EDHF). B2R is instrumental for the supply of blood, oxygen and nutrition to tissues. KKS is present on the vascular endothelium and functions as an autacoid playing major roles in cardiovascular diseases (CVDs) and diabetes. KKS exerts a paramount role in the prevention of thrombosis and atherosclerosis. Such knowledge emphasizes the already prominent value of the ACE-inhibitors (ACEIs) for the treatment of CVDs and diabetes. Indeed, the ACEIs, thanks to their double action (block of the RAS and potentiation of the KKS) are the ideal agents for a rational treatment of these diseases.
Acknowledgments
I wish to thank the students who have contributed to the work on KKS in my lab. This list mentions only the students who got their PhD and the chemists: Jean Barabé, Francis Rioux, François Marceau, Réjean Couture, Pierrette Gaudreault, Pedro D’Orléans-Juste, Guy Drapeau, Nour-Eddine Rhaleb, Daniella Jukic, and the co-author of this paper Fernand Gobeil; chemists: Van Kil Park, Serge Saint-Pierre, and Witold Neugebauer.
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©2016 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Guest Editorial
- Highlight: Kinin 2015 at São Paulo, Brazil
- Kinin 2015 – International Meeting on Kinin System and Peptide Receptors
- Kinins and microglial responses in bipolar disorder: a neuroinflammation hypothesis
- Kinins and peptide receptors
- The role of N-terminal and C-terminal Arg residues from BK on interaction with kinin B2 receptor
- Genetic analysis of hereditary angioedema in a Brazilian family by targeted next generation sequencing
- Cellular localisation of the kinin B1R in the pancreas of streptozotocin-treated rat and the anti-diabetic effect of the antagonist SSR240612
- New mutations in SERPING1 gene of Brazilian patients with hereditary angioedema
- Differential effect of intranasally administrated kinin B1 and B2 receptor antagonists in Alzheimer’s disease mice
- Kinin B1 receptor mediates memory impairment in the rat hippocampus
- Safety and pharmacokinetics of a kinin B1 receptor peptide agonist produced with different counter-ions
- Minireview
- Functional organization of human SAMHD1 and mechanisms of HIV-1 restriction
- Corrigendum
- Corrigendum to: Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis
Artikel in diesem Heft
- Frontmatter
- Guest Editorial
- Highlight: Kinin 2015 at São Paulo, Brazil
- Kinin 2015 – International Meeting on Kinin System and Peptide Receptors
- Kinins and microglial responses in bipolar disorder: a neuroinflammation hypothesis
- Kinins and peptide receptors
- The role of N-terminal and C-terminal Arg residues from BK on interaction with kinin B2 receptor
- Genetic analysis of hereditary angioedema in a Brazilian family by targeted next generation sequencing
- Cellular localisation of the kinin B1R in the pancreas of streptozotocin-treated rat and the anti-diabetic effect of the antagonist SSR240612
- New mutations in SERPING1 gene of Brazilian patients with hereditary angioedema
- Differential effect of intranasally administrated kinin B1 and B2 receptor antagonists in Alzheimer’s disease mice
- Kinin B1 receptor mediates memory impairment in the rat hippocampus
- Safety and pharmacokinetics of a kinin B1 receptor peptide agonist produced with different counter-ions
- Minireview
- Functional organization of human SAMHD1 and mechanisms of HIV-1 restriction
- Corrigendum
- Corrigendum to: Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis