Correlated overexpression of metadherin and SND1 in glioma cells
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Liping Tong
und
Ming Chu
Abstract
Glioma is the most common primary brain tumor with poor prognosis. Effective treatment of glioma remains a big challenge due to complex pathogenic mechanisms. Previous studies have shown that metadherin (MTDH) and its interacting protein staphylococcal nuclease domain containing 1 (SND1) are overexpressed in many solid tumors. To elucidate the role of MDTH and SND1 in the pathogenesis of glioma, we examined the expression of MTDH and SND1 in primary glioma tissues and found that both MTDH and SND1 were highly expressed, with similar expression patterns. Co-expression of MTDH and SND1 was associated with advanced glioma grades. In addition, we detected the interaction between MTDH and SND1 in cultured glioma cell lines. MTDH could promote the expression of p65 and SND1 in glioma cells. However, enhanced SND1 expression by MTDH was abolished by the inhibition of p65. In conclusion, we demonstrated high expression levels MTDH and SND1 in primary glioma tissues. MTDH might promote glioma by inducing SND1 expression through the activation of NF-κB pathway. MTDH and SND1 may serve as the indicator of malignancy and prognosis as well as therapeutic targets for patients with glioma.
Acknowledgments
This work was supported by the Key Project of Chinese Ministry of Education (No. 212043), the Scientific Research Foundation for ROCS, SEM. (No. 2011-508), and Heilongjiang Provincial Science and Technology Innovation Team in Higher Education Institute for Infection and Immunity.
Conflicts of interest statement: The authors declare no conflict of interest.
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©2016 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Reviews
- Ancestral protein reconstruction: techniques and applications
- Mapping the non-standardized biases of ribosome profiling
- Minireview
- The macromolecular crowding effect – from in vitro into the cell
- Research Articles/Short Communications
- Protein Structure and Function
- IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes
- Molecular Medicine
- Correlated overexpression of metadherin and SND1 in glioma cells
- Cell Biology and Signaling
- Melanoma differentiation-associated gene 5 is involved in the induction of stress granules and autophagy by protonophore CCCP
- Suberoylanilide hydroxamic acid (SAHA) promotes the epithelial mesenchymal transition of triple negative breast cancer cells via HDAC8/FOXA1 signals
- Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells
- Phenobarbital inhibits calpain activity and expression in mouse hepatoma cells
Artikel in diesem Heft
- Frontmatter
- Reviews
- Ancestral protein reconstruction: techniques and applications
- Mapping the non-standardized biases of ribosome profiling
- Minireview
- The macromolecular crowding effect – from in vitro into the cell
- Research Articles/Short Communications
- Protein Structure and Function
- IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes
- Molecular Medicine
- Correlated overexpression of metadherin and SND1 in glioma cells
- Cell Biology and Signaling
- Melanoma differentiation-associated gene 5 is involved in the induction of stress granules and autophagy by protonophore CCCP
- Suberoylanilide hydroxamic acid (SAHA) promotes the epithelial mesenchymal transition of triple negative breast cancer cells via HDAC8/FOXA1 signals
- Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells
- Phenobarbital inhibits calpain activity and expression in mouse hepatoma cells
