Startseite Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells
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Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells

  • Renan Orsati Clara EMAIL logo , Nadine Assmann , Ana Carolina Ramos Moreno , Janine Baptista Coimbra , Nadine Nurenberger , Katja Dettmer-Wilde , Peter Josef Oefner und Ana Campa
Veröffentlicht/Copyright: 21. August 2015
Biological Chemistry
Aus der Zeitschrift Biological Chemistry Band 397 Heft 1

Abstract

A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-γ (IFN-γ) and related to poor prognosis in melanomas. Besides its role in cancer, IFN-γ plays a key role in the control of pigmentation homeostasis. Here we measured KP metabolites in human melanoma lines and skin melanocytes and fibroblasts in response to IFN-γ. In general, IFN-γ affected KP in skin cells more than in melanoma cells, supporting IFN-γ roles in skin physiology and that of stromal cells in modulating the tumor microenvironment.

Keywords: interferon-γ; melanocytes; melanoma; metabolism; tryptophan
Corresponding author: Renan Orsati Clara, Faculty of Pharmaceutical Sciences, Department of Clinical Chemistry, University of São Paulo, Av Prof Lineu Prestes, 580, Bl 17, 05508-000 Butantã, São Paulo, SP, Brazil, e-mail: ,

Acknowledgments

This study was supported by Fundação de Amparo a Pesquisa do Estado de São Paulo – FAPESP (process 2010/18477-0), Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq (process 236462/2012-1), and the German Research Foundation (KFO262). We also acknowledge the scholarships awarded by FAPESP to R. Clara and A.C.R. Moreno, and from CNPq to R. Clara and J.B. Coimbra. Further, we thank Ariane Rivellis Julio for the preparation of Figure 1. The authors declare no conflict of interest.

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Received: 2015-5-4
Accepted: 2015-8-18
Published Online: 2015-8-21
Published in Print: 2016-1-1

©2016 by De Gruyter

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. Ancestral protein reconstruction: techniques and applications
  4. Mapping the non-standardized biases of ribosome profiling
  5. Minireview
  6. The macromolecular crowding effect – from in vitro into the cell
  7. Research Articles/Short Communications
  8. Protein Structure and Function
  9. IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes
  10. Molecular Medicine
  11. Correlated overexpression of metadherin and SND1 in glioma cells
  12. Cell Biology and Signaling
  13. Melanoma differentiation-associated gene 5 is involved in the induction of stress granules and autophagy by protonophore CCCP
  14. Suberoylanilide hydroxamic acid (SAHA) promotes the epithelial mesenchymal transition of triple negative breast cancer cells via HDAC8/FOXA1 signals
  15. Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells
  16. Phenobarbital inhibits calpain activity and expression in mouse hepatoma cells
https://doi.org/10.1515/hsz-2015-0173
Schlagwörter für diesen Artikel
interferon-γ; melanocytes; melanoma; metabolism; tryptophan

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. Ancestral protein reconstruction: techniques and applications
  4. Mapping the non-standardized biases of ribosome profiling
  5. Minireview
  6. The macromolecular crowding effect – from in vitro into the cell
  7. Research Articles/Short Communications
  8. Protein Structure and Function
  9. IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes
  10. Molecular Medicine
  11. Correlated overexpression of metadherin and SND1 in glioma cells
  12. Cell Biology and Signaling
  13. Melanoma differentiation-associated gene 5 is involved in the induction of stress granules and autophagy by protonophore CCCP
  14. Suberoylanilide hydroxamic acid (SAHA) promotes the epithelial mesenchymal transition of triple negative breast cancer cells via HDAC8/FOXA1 signals
  15. Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells
  16. Phenobarbital inhibits calpain activity and expression in mouse hepatoma cells
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