Angiotensin-converting enzyme overexpression in myelocytes enhances the immune response
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Kenneth E. Bernstein
, Romer A. Gonzalez-Villalobos
, Jorge F. Giani , Kandarp Shah , Ellen Bernstein , Tea Janjulia , Yosef Koronyo , Peng D. Shi , Maya Koronyo-Hamaoui , Sebastien Fuchs und Xiao Z. Shen
Abstract
Angiotensin-converting enzyme (ACE) plays an important role in blood pressure control. ACE also has effects on renal function, reproduction, hematopoiesis, and several aspects of the immune response. ACE 10/10 mice overexpress ACE in monocytic cells; macrophages from ACE 10/10 mice demonstrate increased polarization toward a proinflammatory phenotype. As a result, ACE 10/10 mice have a highly effective immune response following challenge with melanoma, bacterial infection, or Alzheimer disease. As shown in ACE 10/10 mice, enhanced monocytic function greatly contributes to the ability of the immune response to defend against a wide variety of antigenic and non-antigenic challenges.
Acknowledgments
The authors acknowledge the tireless support of Mr. Brian Taylor. This study was supported by the National Institute of Health grants grants R01 HL110353, T32 DK007770, and R00 HL088000; by Beginning Grant-in-Aid 13BGIA14680069 and Scientist Development Grant 11SDG6770006 from the American Heart Association; by the Coins for Alzheimer’s Research Trust (CART) Fund; by the BrightFocus Foundation (former AHAF), the Maurice Marciano Family Foundation, and the National Center for Advancing Translational Sciences through CTSI Grant UL1TR000124. The authors dedicate the manuscript to the memory of Natalie Radom Bernstein who died on April 9, 2013, and Salomon Moni Hamaoui who died on March 6, 1994, both of Alzheimer disease.
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©2014 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Guest Editorial
- Highlight: The protease web
- Angiotensin-I converting enzyme (ACE): structure, biological roles, and molecular basis for chloride ion dependence
- Non-B HIV-1 subtypes in sub-Saharan Africa: impact of subtype on protease inhibitor efficacy
- Inflammatory outcomes of apoptosis, necrosis and necroptosis
- Angiotensin-converting enzyme overexpression in myelocytes enhances the immune response
- The leader proteinase of foot-and-mouth disease virus: structure-function relationships in a proteolytic virulence factor
- Immune-modulating effects of alpha-1 antitrypsin
- Mammalian gamete fusion depends on the inhibition of ovastacin by fetuin-B
- The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length
- Membrane-type I matrix metalloproteinase-dependent ectodomain shedding of mucin16/ CA-125 on ovarian cancer cells modulates adhesion and invasion of peritoneal mesothelium
- Homology model of human prothrombinase based on the crystal structure of Pseutarin C
- Specific targeting of human caspases using designed ankyrin repeat proteins
- Analysis of the evolution of granule associated serine proteases of immune defence (GASPIDs) suggests a revised nomenclature
Artikel in diesem Heft
- Frontmatter
- Guest Editorial
- Highlight: The protease web
- Angiotensin-I converting enzyme (ACE): structure, biological roles, and molecular basis for chloride ion dependence
- Non-B HIV-1 subtypes in sub-Saharan Africa: impact of subtype on protease inhibitor efficacy
- Inflammatory outcomes of apoptosis, necrosis and necroptosis
- Angiotensin-converting enzyme overexpression in myelocytes enhances the immune response
- The leader proteinase of foot-and-mouth disease virus: structure-function relationships in a proteolytic virulence factor
- Immune-modulating effects of alpha-1 antitrypsin
- Mammalian gamete fusion depends on the inhibition of ovastacin by fetuin-B
- The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length
- Membrane-type I matrix metalloproteinase-dependent ectodomain shedding of mucin16/ CA-125 on ovarian cancer cells modulates adhesion and invasion of peritoneal mesothelium
- Homology model of human prothrombinase based on the crystal structure of Pseutarin C
- Specific targeting of human caspases using designed ankyrin repeat proteins
- Analysis of the evolution of granule associated serine proteases of immune defence (GASPIDs) suggests a revised nomenclature