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The globin superfamily: functions in nitric oxide formation and decay

  • Jesús Tejero und Mark T. Gladwin EMAIL logo
Veröffentlicht/Copyright: 30. Januar 2014
Biological Chemistry
Aus der Zeitschrift Biological Chemistry Band 395 Heft 6

Abstract

Globin proteins are ubiquitous in living organisms and carry out a variety of functions related to the ability of their prosthetic heme group to bind gaseous ligands, such as oxygen, nitric oxide (NO), and CO. Moreover, they catalyze important reactions with nitrogen oxide species, such as NO dioxygenation and nitrite reduction. The formation of NO from nitrite is a reaction catalyzed by globins that has received increasing attention due to its potential as a hypoxic NO signaling mechanism. In this review, we revisit the current knowledge about the role of globins in NO formation and its physiological implications.

Keywords: cytoglobin; globin; neuroglobin; nitric oxide; nitric oxide dioxygenation; nitrite
Corresponding author: Mark T. Gladwin, Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA; and Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, E1244 BST, 200 Lothrop Street, Pittsburgh, PA 15213, USA, e-mail:

Acknowledgments

This work was supported by National Institutes of Health Grants HL098032, HL096973, DK085852 and funding from the Institute for Transfusion Medicine and the Hemophilia Center of Western Pennsylvania (to M.T.G), and by funding from the Competitive Medical Research Fund of the UPMC Health System (to J.T.).

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Received: 2013-12-3
Accepted: 2014-1-27
Published Online: 2014-1-30
Published in Print: 2014-6-1

©2014 by Walter de Gruyter Berlin/Boston

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https://doi.org/10.1515/hsz-2013-0289
Schlagwörter für diesen Artikel
cytoglobin; globin; neuroglobin; nitric oxide; nitric oxide dioxygenation; nitrite

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. The top skin-associated genes: a comparative analysis of human and mouse skin transcriptomes
  4. Human dyskerin: beyond telomeres
  5. Assembly and function of small RNA – Argonaute protein complexes
  6. Minireview
  7. The globin superfamily: functions in nitric oxide formation and decay
  8. Research Articles/Short Communications
  9. Protein Structure and Function
  10. N-homocysteinylation of apolipoprotein A-I impairs the protein’s antioxidant ability but not its cholesterol efflux capacity
  11. Lucimycin, an antifungal peptide from the therapeutic maggot of the common green bottle fly Lucilia sericata
  12. A lysine-methionine exchange in a coronavirus surface protein transforms a retention motif into an endocytosis signal
  13. Cell Biology and Signaling
  14. Upregulation of the thioredoxin-dependent redox system during differentiation of 3T3-L1 cells to adipocytes
  15. Novel Techniques
  16. Shortening distance of forward and reverse primers for nucleic acid isothermal amplification
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