Maternal hypothyroidism prolongs gestation period and impairs glucose tolerance in offspring of Wistar rats
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Ubong Edem David
and
Adesoji Adedipe Fasanmade
Abstract
Objectives
Pregnancy is a critical period keenly regulated by both maternal and foetal factors and a shift in these factors could result in severe complications manifesting in foetal and adult life. However, maternal hypothyroidism before and/or during pregnancy is a critical factor. This study investigated the effect of maternal hypothyroidism on glucose tolerance and thyroid function in male and female offspring.
Methods
Fifteen adult female Wistar rats were divided into three groups: Group 1 (sham-control), Group 2 (thyrodectomized) and Group 3 (thyroidectomised + L-thyroxine treated). Blood thyroxine (T4) level was measured on the day 10 after thyroidectomy in Groups 1 and 2, and day 35 in Group 3. Males were introduced to the female rats after T4 measurement. At PND-112, T4 levels of their offspring were measured. Oral Glucose Tolerance Test (OGTT) was measured in offspring at PND-133.
Results
Thyroxine reduced significantly in Group 2 and their offspring (male and female) compared to Group 3 while gestation period was prolonged significantly in Group 2 compared to Group 1. Hypothyroid male offspring showed depressed glucose tolerance, however, no effect was observed in female offspring.
Conclusions
This study suggests that maternal hypothyroidism prolonged gestation period, induced foetal hypothyroidism in both genders and depressed glucose tolerance in male offspring.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: The local Institutional Review Board deemed the study exempt from review.
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
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- Letter to the Editor
- Continuing medical education in Covid-19 pandemic
- Original Articles
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- Clinical investigation of lipoprotein (a) levels in type 2 diabetics for cardiovascular diseases prediction and prognosis
- Exploring the relationship between vitamin D and leptin hormones in type 2 diabetes mellitus patients from Kuwait
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- Association of obesity in T2DM with differential polymorphism of ghrelin, growth hormone secretagogue receptor-1 and telomeres maintenance genes
- Effect of different dietary fats on inflammation and glucose intolerance in high fructose and high fat fed experimental animals
- Biological reference interval of nitric oxide in health and disease
- Maternal hypothyroidism prolongs gestation period and impairs glucose tolerance in offspring of Wistar rats
- A study on serum homocysteine and oxidized LDL as markers of cardiovascular risk in patients with overt hypothyroidism
- The study of serum hsCRP, ferritin, IL-6 and plasma D-dimer in COVID-19: a retrospective study
- Swimming exercise improves SIRT1, NF-κB, and IL–1β protein levels and pancreatic tissue injury in ovariectomized diabetic rats
- Short Communications
- The second wave of COVID-19 results in outbreak of mucormycosis: diabetes and immunological perspective
- A study on lipoprotein-a and PAI-1 in women with polycystic ovary syndrome
- Review Articles
- Oxytocin, the panacea for long-COVID? a review
- COVID-19 infection in pregnancy: a review of existing knowledge
Articles in the same Issue
- Frontmatter
- Letter to the Editor
- Continuing medical education in Covid-19 pandemic
- Original Articles
- Reduced irisin levels in patients with acromegaly
- Clinical investigation of lipoprotein (a) levels in type 2 diabetics for cardiovascular diseases prediction and prognosis
- Exploring the relationship between vitamin D and leptin hormones in type 2 diabetes mellitus patients from Kuwait
- Serum 25(OH) vitamin D level in Relapsing-Remitting Multiple Sclerosis and clinically isolated syndrome groups
- Hypoglycemic, hypolipidemic and hepatoprotective effects of Alpinia officinarum on nicotinamide/streptozotocin induced type II diabetic rats
- Association of obesity in T2DM with differential polymorphism of ghrelin, growth hormone secretagogue receptor-1 and telomeres maintenance genes
- Effect of different dietary fats on inflammation and glucose intolerance in high fructose and high fat fed experimental animals
- Biological reference interval of nitric oxide in health and disease
- Maternal hypothyroidism prolongs gestation period and impairs glucose tolerance in offspring of Wistar rats
- A study on serum homocysteine and oxidized LDL as markers of cardiovascular risk in patients with overt hypothyroidism
- The study of serum hsCRP, ferritin, IL-6 and plasma D-dimer in COVID-19: a retrospective study
- Swimming exercise improves SIRT1, NF-κB, and IL–1β protein levels and pancreatic tissue injury in ovariectomized diabetic rats
- Short Communications
- The second wave of COVID-19 results in outbreak of mucormycosis: diabetes and immunological perspective
- A study on lipoprotein-a and PAI-1 in women with polycystic ovary syndrome
- Review Articles
- Oxytocin, the panacea for long-COVID? a review
- COVID-19 infection in pregnancy: a review of existing knowledge
