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Hypoglycemic, hypolipidemic and hepatoprotective effects of Alpinia officinarum on nicotinamide/streptozotocin induced type II diabetic rats

  • Hamid Heidari , Azam Khalaj , Sima Khani , Maasoume Abdollahi , Hamid Farahani and Samira Khani ORCID logo EMAIL logo
Published/Copyright: May 2, 2022
Hormone Molecular Biology and Clinical Investigation
From the journal Hormone Molecular Biology and Clinical Investigation Volume 43 Issue 3

Abstract

Objectives

Alpinia officinarum Hance, commonly known as lesser galangal, is a member of the ginger family (Zingiberaceae) traditionally used for many decades to treat inflammation, pain, stomach ache and cold. In the present study, the antidiabetic and hypolipidemic potentials of the hydroalcoholic extract of A. officinarum (AO) were investigated in the nicotinamide/streptozotocin induced type II diabetic rats.

Methods

Male Wistar rats were divided into following six groups: Group I was normal control rats. Group II: normal diabetic control, Group III: Diabetic rats treated with glibenclamide (0.25 mg/kg), IV, V and VI: Diabetic rats treated with 100, 200 and 500 mg/kg AO hydroalcoholic extract by daily gavage for 28 days, respectively. At the end of treatment, biochemical analysis, histological study, phytochemical analysis and acute toxicity tests were carried out.

Results

The results show significant reduction in blood glucose, serum lipid profiles, and liver enzyme levels in diabetic rats compared with diabetic control in AO treated group.

Conclusions

In conclusion, the present study demonstrated that AO extract had significant (p<0.05) antidiabetic and anti-hyperlipidemia effects in addition to hepatoprotective effect in type II diabetic rats.

Keywords: Alpinia officinarum ; antidiabetic; hypolipidemic; streptozotocin
Corresponding author: Samira Khani, Neuroscience Research Center, Qom University of Medical Sciences, Shahid-Beheshti Blvd., Qom, Iran, Phone: 02531971033, E-mail:

Acknowledgment

The authors acknowledge the technicians of Cellular and Molecular Research Center, Qom University of Medical Sciences for their valuable assistance.

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: The protocols used have received approval from the Medical Research Ethics Commission of Qom University of Medical Sciences (Code: MUQ.REC.1395.127).

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Received: 2021-06-11
Accepted: 2022-03-12
Published Online: 2022-05-02

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Letter to the Editor
  3. Continuing medical education in Covid-19 pandemic
  4. Original Articles
  5. Reduced irisin levels in patients with acromegaly
  6. Clinical investigation of lipoprotein (a) levels in type 2 diabetics for cardiovascular diseases prediction and prognosis
  7. Exploring the relationship between vitamin D and leptin hormones in type 2 diabetes mellitus patients from Kuwait
  8. Serum 25(OH) vitamin D level in Relapsing-Remitting Multiple Sclerosis and clinically isolated syndrome groups
  9. Hypoglycemic, hypolipidemic and hepatoprotective effects of Alpinia officinarum on nicotinamide/streptozotocin induced type II diabetic rats
  10. Association of obesity in T2DM with differential polymorphism of ghrelin, growth hormone secretagogue receptor-1 and telomeres maintenance genes
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  12. Biological reference interval of nitric oxide in health and disease
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  14. A study on serum homocysteine and oxidized LDL as markers of cardiovascular risk in patients with overt hypothyroidism
  15. The study of serum hsCRP, ferritin, IL-6 and plasma D-dimer in COVID-19: a retrospective study
  16. Swimming exercise improves SIRT1, NF-κB, and IL–1β protein levels and pancreatic tissue injury in ovariectomized diabetic rats
  17. Short Communications
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  19. A study on lipoprotein-a and PAI-1 in women with polycystic ovary syndrome
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https://doi.org/10.1515/hmbci-2021-0050
Keywords for this article
Alpinia officinarum; antidiabetic; hypolipidemic; streptozotocin

Articles in the same Issue

  1. Frontmatter
  2. Letter to the Editor
  3. Continuing medical education in Covid-19 pandemic
  4. Original Articles
  5. Reduced irisin levels in patients with acromegaly
  6. Clinical investigation of lipoprotein (a) levels in type 2 diabetics for cardiovascular diseases prediction and prognosis
  7. Exploring the relationship between vitamin D and leptin hormones in type 2 diabetes mellitus patients from Kuwait
  8. Serum 25(OH) vitamin D level in Relapsing-Remitting Multiple Sclerosis and clinically isolated syndrome groups
  9. Hypoglycemic, hypolipidemic and hepatoprotective effects of Alpinia officinarum on nicotinamide/streptozotocin induced type II diabetic rats
  10. Association of obesity in T2DM with differential polymorphism of ghrelin, growth hormone secretagogue receptor-1 and telomeres maintenance genes
  11. Effect of different dietary fats on inflammation and glucose intolerance in high fructose and high fat fed experimental animals
  12. Biological reference interval of nitric oxide in health and disease
  13. Maternal hypothyroidism prolongs gestation period and impairs glucose tolerance in offspring of Wistar rats
  14. A study on serum homocysteine and oxidized LDL as markers of cardiovascular risk in patients with overt hypothyroidism
  15. The study of serum hsCRP, ferritin, IL-6 and plasma D-dimer in COVID-19: a retrospective study
  16. Swimming exercise improves SIRT1, NF-κB, and IL–1β protein levels and pancreatic tissue injury in ovariectomized diabetic rats
  17. Short Communications
  18. The second wave of COVID-19 results in outbreak of mucormycosis: diabetes and immunological perspective
  19. A study on lipoprotein-a and PAI-1 in women with polycystic ovary syndrome
  20. Review Articles
  21. Oxytocin, the panacea for long-COVID? a review
  22. COVID-19 infection in pregnancy: a review of existing knowledge
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