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The serum levels of testosterone in coronary artery disease patients; relation to NO, eNOS, endothelin-1, and disease severity

  • Saeideh Akseh , Mohammad-Ali Karimi , Nasser Safaie , Amir Valizadeh , Dara Rahmanpour , Masoud Pezeshkian , Mohammad Nouri , Yousef Faridvand ORCID logo EMAIL logo and Ahmadreza Jodati ORCID logo EMAIL logo
Published/Copyright: September 9, 2021
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Hormone Molecular Biology and Clinical Investigation
From the journal Hormone Molecular Biology and Clinical Investigation Volume 43 Issue 1

Abstract

Objectives

The changes in testosterone level and its correlation with the endothelial nitric oxide systems balance in patients with coronary artery disease (CAD) remains uncertain. Therefore, in our study, we aimed to evaluate the levels of testosterone, endothelin-1 (ET-1), nitric oxide (NO), and endothelial NOS (eNOS) in CAD patients, and control group to find the relationship between these parameters and disease severity.

Methods

Forty-four patients as CAD group with significant (≥50%) stenosis confirmed by angiography was included in the study, and 40 healthy men were included as the control group. According to the number of vessels obstruction, CAD severity was determined. The serum indicated parameters were assessed to discriminate between patients and controls.

Results

It was found that testosterone levels in the CDA group were significantly lower than those of the control group (p<0.05). In addition, the level of ET-1 in the CAD group was higher than that in the control group, but levels of NO and eNOS in observation were significantly lower than those in the control group (p<0.05). The correlation analysis revealed that testosterone was passivity correlated with serum NO levels (r=0.550, p=0.001).

Conclusions

The current study reports that serum levels of testosterone are closely related to endothelial NO levels and might be of relevance to the pathogenesis of endothelial dysfunction and disease severity in CAD patients.

Keywords: coronary artery disease; eNOS; ET-1; NO; testosterone
Corresponding authors: Yousef Faridvand, Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; and Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran, E-mail: ; and Ahmadreza Jodati, Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, E-mail:

Funding source: Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Award Identifier / Grant number: 62625

  1. Research funding: This work was supported by the Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran (Award ID 62625).

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The study protocol was approved by the Local Ethical Committee of Tabriz Medical University.

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Received: 2021-03-19
Accepted: 2021-08-20
Published Online: 2021-09-09

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Letter to the Editor
  3. Is COVID-19 gender biased?
  4. Opinion Paper
  5. The probable mechanism of reduced androgen level in COVID-19 patients
  6. Original Articles
  7. Effect of Auraptene on angiogenesis in Xenograft model of breast cancer
  8. Zingiber officinale (Ginger) hydroalcoholic extract improved avoidance memory in rat model of streptozotocin-induced diabetes by regulating brain oxidative stress
  9. Role of N-terminal pro-B-type natriuretic peptide and troponin T in predicting right ventricular recovery in myocardial infarction
  10. Is there any role of interleukin-6 and high sensitive C-reactive protein in predicting IVF/ICSI success? A prospective cohort study
  11. Does serum TSH level act as a surrogate marker for psychological stress and cardio-metabolic risk among adolescent and young people?
  12. The effects of thyroid dysfunction on DNA damage and apoptosis in liver and heart tissues of rats
  13. The serum levels of testosterone in coronary artery disease patients; relation to NO, eNOS, endothelin-1, and disease severity
  14. Interaction of high-intensity endurance exercise and nandrolone on cardiac remodeling: role of adipo-cardiac axis
  15. Psoralidin exerts anti-tumor, anti-angiogenic, and immunostimulatory activities in 4T1 tumor‐bearing balb/c mice
  16. Short Communication
  17. COVID-19 pandemic and potential of artificial intelligence
  18. Case Report
  19. A positive urine pregnancy test with haemoperitoneum: misdiagnosed postpartum choriocarcinoma with uterine rupture mimicking ruptured ectopic pregnancy
  20. Review Articles
  21. COVID 19 vaccine in patients of hypercoagulable disorders: a clinical perspective
  22. Synopsis of symptoms of COVID-19 during second wave of the pandemic in India
  23. Clustered regularly interspaced short palindromic repeats, a glimpse – impacts in molecular biology, trends and highlights
https://doi.org/10.1515/hmbci-2021-0026
Keywords for this article
coronary artery disease; eNOS; ET-1; NO; testosterone

Articles in the same Issue

  1. Frontmatter
  2. Letter to the Editor
  3. Is COVID-19 gender biased?
  4. Opinion Paper
  5. The probable mechanism of reduced androgen level in COVID-19 patients
  6. Original Articles
  7. Effect of Auraptene on angiogenesis in Xenograft model of breast cancer
  8. Zingiber officinale (Ginger) hydroalcoholic extract improved avoidance memory in rat model of streptozotocin-induced diabetes by regulating brain oxidative stress
  9. Role of N-terminal pro-B-type natriuretic peptide and troponin T in predicting right ventricular recovery in myocardial infarction
  10. Is there any role of interleukin-6 and high sensitive C-reactive protein in predicting IVF/ICSI success? A prospective cohort study
  11. Does serum TSH level act as a surrogate marker for psychological stress and cardio-metabolic risk among adolescent and young people?
  12. The effects of thyroid dysfunction on DNA damage and apoptosis in liver and heart tissues of rats
  13. The serum levels of testosterone in coronary artery disease patients; relation to NO, eNOS, endothelin-1, and disease severity
  14. Interaction of high-intensity endurance exercise and nandrolone on cardiac remodeling: role of adipo-cardiac axis
  15. Psoralidin exerts anti-tumor, anti-angiogenic, and immunostimulatory activities in 4T1 tumor‐bearing balb/c mice
  16. Short Communication
  17. COVID-19 pandemic and potential of artificial intelligence
  18. Case Report
  19. A positive urine pregnancy test with haemoperitoneum: misdiagnosed postpartum choriocarcinoma with uterine rupture mimicking ruptured ectopic pregnancy
  20. Review Articles
  21. COVID 19 vaccine in patients of hypercoagulable disorders: a clinical perspective
  22. Synopsis of symptoms of COVID-19 during second wave of the pandemic in India
  23. Clustered regularly interspaced short palindromic repeats, a glimpse – impacts in molecular biology, trends and highlights
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