Comparison of the effects of zinc oxide and zinc oxide nanoparticles on the expression of hepcidin gene in rat liver
-
Pirouz Pourmohammad
,
Reza Alipanah-Moghadam
,
Ali Nemati
Abstract
Objectives
Nanoparticles have special properties, such as increased intestinal absorption, permeability, and so on. Zinc oxide (ZnO) nanoparticles have medical applications such as using in drug production. Studies of ZnO nanoparticles have shown the role of these particles in reducing or increasing the genes expression. Given the important role of hepcidin in the development of anemia and iron overload diseases, this study investigated the effect of ZnO nanoparticles on the hepatic expression of the hepcidin gene to help find a way to treat these diseases.
Methods
In this experimental study, 24 male Westar rats were divided into three groups: control, ZnO treating group and ZnO nanoparticle treating group. Both ZnO and ZnO nanoparticles were injected with 50 mg/kg body weight for 14 days. At the end, serums were collected and iron, ferritin and IL-6 levels were measured. Expression of the hepcidin gene was done by Real Time PCR.
Results
ZnO and the ZnO nanoparticle significantly increased the expression of the hepcidin gene relative to the control group. The increase in expression of the hepcidin gene in ZnO nanoparticles was more significant than in the ZnO.
Conclusion
ZnO nanoparticles led to significant increase in expression of the hepcidin gene.
Research funding: This work was financially supported by the Ardabil University of Medical Sciences, Faculty of Medicine. We are grateful to the Ardabil University of Medical Sciences for financial support.
Author Contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: None declared.
Informed consent: Not applicable
Ethical approval: This research has been approved by the Ethics Committee of Ardabil University of Medical Sciences (ID: IR.ARUMS.REC.1395.132) in terms of animal study ethical standards.
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Letter to the Editor
- Kerala model for combating COVID-19 pandemic
- Original Articles
- Evaluation of the potential anticancer activity of different vitamin D metabolites on colorectal and breast cancer cell lines
- Relationship between the levels of serum fibroblast growth factor 19 and metabolic factors in obese and normal weight subjects with and without type 2 diabetes mellitus: a case-control study
- Early-life stress altered pancreatic Krebs cycle-related enzyme activities in response to young adulthood physical and psychological stress in male rat offspring
- Effect of short-term and long-term traffic noise exposure on the thyroid gland in adult rats: a sexual dimorphic study
- The effect of thyroid dysfunction and treatment on adropin, asprosin and preptin levels in rats
- Comparison of the effects of zinc oxide and zinc oxide nanoparticles on the expression of hepcidin gene in rat liver
- Comparison between Iberet Folic® and Zincofer® in treatment of iron deficiency anaemia in pregnancy
- Mini Review
- COVID-19 and pregnancy: are they friends or enemies?
- Review Articles
- COVID-19: a review on SARS-CoV-2 origin, epidemiology, virology, clinical manifestations and complications with special emphasis on adverse outcome in Bhopal Gas Tragedy survivor
- COVID-19 and neurology perspective
- COVID-19 and nutritional deficiency: a review of existing knowledge
- COVID-19 and geriatric population: from pathophysiology to clinical perspectives
- COVID-19 and cardiovascular disease: a review of current knowledge
- How do different histologic components of mixed endometrial carcinomas affect prognosis? Does it really matter?
Artikel in diesem Heft
- Frontmatter
- Letter to the Editor
- Kerala model for combating COVID-19 pandemic
- Original Articles
- Evaluation of the potential anticancer activity of different vitamin D metabolites on colorectal and breast cancer cell lines
- Relationship between the levels of serum fibroblast growth factor 19 and metabolic factors in obese and normal weight subjects with and without type 2 diabetes mellitus: a case-control study
- Early-life stress altered pancreatic Krebs cycle-related enzyme activities in response to young adulthood physical and psychological stress in male rat offspring
- Effect of short-term and long-term traffic noise exposure on the thyroid gland in adult rats: a sexual dimorphic study
- The effect of thyroid dysfunction and treatment on adropin, asprosin and preptin levels in rats
- Comparison of the effects of zinc oxide and zinc oxide nanoparticles on the expression of hepcidin gene in rat liver
- Comparison between Iberet Folic® and Zincofer® in treatment of iron deficiency anaemia in pregnancy
- Mini Review
- COVID-19 and pregnancy: are they friends or enemies?
- Review Articles
- COVID-19: a review on SARS-CoV-2 origin, epidemiology, virology, clinical manifestations and complications with special emphasis on adverse outcome in Bhopal Gas Tragedy survivor
- COVID-19 and neurology perspective
- COVID-19 and nutritional deficiency: a review of existing knowledge
- COVID-19 and geriatric population: from pathophysiology to clinical perspectives
- COVID-19 and cardiovascular disease: a review of current knowledge
- How do different histologic components of mixed endometrial carcinomas affect prognosis? Does it really matter?
