Modulatory effect of tropisetron in the liver of streptozotocin-induced diabetes in rats: biochemical and histological evidence
-
Roya Naderi
,
Bagher Pourheydar
Abstract
Objectives
There is an association between diabetes and liver disorders. Oxidative stress plays a crucial role in the pathology of hepatic abnormalities in diabetes. In this study, the effect of Tropisetron on the oxidative damage and histological alterations in the liver of type 1 diabetes mellitus (DM) were evaluated.
Methods
Thiry-five male Wistar rats were randomly divided into five experimental groups (n = 7): control (C), tropisetron (T), diabetes (D), diabetes + tropisetron (D + T) and diabetes + glibenclamide (D + G). A single injection of streptozotocin (STZ, 50 mg/kg; i.p) was used to induce diabetes. Tropisetron (3 mg/kg; i.p), as a 5-HT3 receptor antagonist and glibenclamide (1 mg/kg; i.p), as a positive control were given once daily for 2 weeks. Finally, animals were euthanized and liver samples were obtained for histopathological examination and biochemical measurements including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) levels.
Results
There is a significant increase in MDA (p < 0.001) level and a significant decrease (p < 0.001) in SOD and GPx contents in diabetic animals. Tropisetron attenuated MDA levels (p < 0.001) and enhanced SOD (p < 0.05) and GPx (p < 0.01) activities accompanied by histopathological improvement in the diabetes liver. Similar results were achieved in the rats treated with the standard drug, namely: glibenclamide.
Conclusions
Our findings indicate that tropisetron mitigates liver damage in the diabetes rats in part by attenuation of oxidative stress.
Research Funding: This study was supported by a grant from the Urmia University of Medical Science.
Competing Interest: The authors declare no conflict of interests.
Informed Consent: Not applicable.
Ethical Approval: In the present study, all experimental formalities were in accordance with the Urmia University of Medical Sciences guidelines for research on laboratory animals.
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- Modulatory effect of tropisetron in the liver of streptozotocin-induced diabetes in rats: biochemical and histological evidence
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Artikel in diesem Heft
- Special Section: "Update in the management of ovarian cancer"; Guest Editors: René Druckmann and Adolf E. Schindler
- Editorial
- Preface to special issue: update in the management of ovarian cancer
- Original Article
- Ovarian cancer screening in the general population
- Review Articles
- Non-surgical prevention strategies in women with hereditary breast and ovarian cancer syndromes
- Hyperthermic intraperitoneal chemotherapy in ovarian cancer: an update
- Genetic testing in ovarian cancer – clinical impact and current practices
- The place of secondary complete cytoreductive surgery in advanced ovarian cancer
- An update on preoperative assessment of the resectability of advanced ovarian cancer
- Impact of retroperitoneal lymph node dissection in ovarian cancer – time for paradigm shift?
- Minireviews
- Ultrasound screening of ovarian cancer
- How to manage BRCA mutation carriers?
- Regular Issue
- Original Articles
- Progestogen addition with low-dose levonorgestrel intrauterine system in menopausal hormone treatment gives less normal breast tissue proliferation than oral norethisterone acetate or medroxyprogesterone acetate
- The effectiveness of military physical exercise on irisin concentrations and oxidative stress among male healthy volunteers
- Periodontal status and bone metabolism in women in reproductive and postmenopausal periods
- Modulatory effect of tropisetron in the liver of streptozotocin-induced diabetes in rats: biochemical and histological evidence
- Celecoxib versus mefenamic acid in the treatment of primary dysmenorrhea
- The predictive role of amylase and lipase levels on pancreas injury diagnosis in patients with blunt abdominal trauma
- Case Report
- Low hormone levels during an attack of systemic capillary leak syndrome normalizing after treatment
