Non-surgical prevention strategies in women with hereditary breast and ovarian cancer syndromes
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Christian F. Singer
Abstract
Objectives
To review non-surgical prevention strategies in women with hereditary breast and ovarian cancer syndromes.
Content
Women with a gBRCA1 or 2 mutations face a high cumulative breast and ovarian cancer risk. While bilateral mastectomy (PBM) and bilateral salpingo-oophrectomy (PBSO) profoundly reduce the respective cancer risks, they are also associated with considerable side effects. There is therefore an urgent need for alternative and non-surgical risk reduction options. Tamoxifen and aromatase inhibitors have both been evaluated in secondary prevention, but their benefit in primary prevention is currently unknown in BRCA mutation carriers. In addition, their use is compromised by their side effect profile which makes them less appealing for a use in chemoprevention.
Summary and outlook
Denosumab is a well-tolerated osteoprotective drug, which has been demonstrated to have a potential preventive effect particularly in BRCA1-deficient models in vitro. The prospectively randomized double-blind BRCA-P trial is currently investigating the preventative effect of denosumab in healthy BRCA1 germ line mutation carriers.
Research funding: None declared.
Conflict of interest: None declared.
Informed consent: Not applicable.
Ethical approval: Not applicable.
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Special Section: "Update in the management of ovarian cancer"; Guest Editors: René Druckmann and Adolf E. Schindler
- Editorial
- Preface to special issue: update in the management of ovarian cancer
- Original Article
- Ovarian cancer screening in the general population
- Review Articles
- Non-surgical prevention strategies in women with hereditary breast and ovarian cancer syndromes
- Hyperthermic intraperitoneal chemotherapy in ovarian cancer: an update
- Genetic testing in ovarian cancer – clinical impact and current practices
- The place of secondary complete cytoreductive surgery in advanced ovarian cancer
- An update on preoperative assessment of the resectability of advanced ovarian cancer
- Impact of retroperitoneal lymph node dissection in ovarian cancer – time for paradigm shift?
- Minireviews
- Ultrasound screening of ovarian cancer
- How to manage BRCA mutation carriers?
- Regular Issue
- Original Articles
- Progestogen addition with low-dose levonorgestrel intrauterine system in menopausal hormone treatment gives less normal breast tissue proliferation than oral norethisterone acetate or medroxyprogesterone acetate
- The effectiveness of military physical exercise on irisin concentrations and oxidative stress among male healthy volunteers
- Periodontal status and bone metabolism in women in reproductive and postmenopausal periods
- Modulatory effect of tropisetron in the liver of streptozotocin-induced diabetes in rats: biochemical and histological evidence
- Celecoxib versus mefenamic acid in the treatment of primary dysmenorrhea
- The predictive role of amylase and lipase levels on pancreas injury diagnosis in patients with blunt abdominal trauma
- Case Report
- Low hormone levels during an attack of systemic capillary leak syndrome normalizing after treatment
Articles in the same Issue
- Special Section: "Update in the management of ovarian cancer"; Guest Editors: René Druckmann and Adolf E. Schindler
- Editorial
- Preface to special issue: update in the management of ovarian cancer
- Original Article
- Ovarian cancer screening in the general population
- Review Articles
- Non-surgical prevention strategies in women with hereditary breast and ovarian cancer syndromes
- Hyperthermic intraperitoneal chemotherapy in ovarian cancer: an update
- Genetic testing in ovarian cancer – clinical impact and current practices
- The place of secondary complete cytoreductive surgery in advanced ovarian cancer
- An update on preoperative assessment of the resectability of advanced ovarian cancer
- Impact of retroperitoneal lymph node dissection in ovarian cancer – time for paradigm shift?
- Minireviews
- Ultrasound screening of ovarian cancer
- How to manage BRCA mutation carriers?
- Regular Issue
- Original Articles
- Progestogen addition with low-dose levonorgestrel intrauterine system in menopausal hormone treatment gives less normal breast tissue proliferation than oral norethisterone acetate or medroxyprogesterone acetate
- The effectiveness of military physical exercise on irisin concentrations and oxidative stress among male healthy volunteers
- Periodontal status and bone metabolism in women in reproductive and postmenopausal periods
- Modulatory effect of tropisetron in the liver of streptozotocin-induced diabetes in rats: biochemical and histological evidence
- Celecoxib versus mefenamic acid in the treatment of primary dysmenorrhea
- The predictive role of amylase and lipase levels on pancreas injury diagnosis in patients with blunt abdominal trauma
- Case Report
- Low hormone levels during an attack of systemic capillary leak syndrome normalizing after treatment
