Periodontal status and bone metabolism in women in reproductive and postmenopausal periods

Iryna Mazur; Bassymbek Dilbarkhanov; Xeniya Kuracha; Volodymyr Novoshytskyy; Iryna Suprunovych; Kairat Zhakipbekov

doi:10.1515/hmbci-2020-0011

Article

Periodontal status and bone metabolism in women in reproductive and postmenopausal periods

Iryna Mazur , Bassymbek Dilbarkhanov , Xeniya Kuracha , Volodymyr Novoshytskyy , Iryna Suprunovych and Kairat Zhakipbekov

Published/Copyright: August 3, 2020

Published by

Become an author with De Gruyter Brill

Submit Manuscript Author Information

From the journal Hormone Molecular Biology and Clinical Investigation Volume 41 Issue 3

Abstract

Objectives

Chronic periodontitis is one of the most common diseases in the world. Periodontitis occurs more frequently in postmenopausal women due to hormonal changes and in patients with osteoporosis. Thus, the aim of our study was to compare levels of alveolar bone loss of mandible and maxilla and bone tissue remodeling markers in women of reproductive and postmenopausal periods.

Methods

Fifty-nine women aged 25–68 years were enrolled in a cross-sectional study and divided into two groups. Group I consisted of 42 women of reproductive age and Group II included 17 women in their postmenopausal period. The level of alveolar bone loss of mandible and maxilla was assessed using dental panoramic radiography, and the level of bone remodeling markers (Beta C-terminal telopeptide of type I collagen [β-CTx] and osteocalcin) was obtained in both groups.

Results

Women in the postmenopausal period have higher level of alveolar bone loss in mandible and maxilla than women of reproductive age. The level of ß-CTx and osteocalcin was significantly higher in Group II, compared to Group I (p=0.002 and p=0.005, respectively).

Conclusions

In postmenopausal women, on the background of significantly higher bone remodeling, an increase of alveolar bone loss of mandible and maxilla was observed.

Keywords: alveolar bone loss; bone metabolism; bone remodeling markers; chronic periodontitis; postmenopausal period

Corresponding author: Kairat Zhakipbekov, Department of Organization, Management and Economics of Pharmacy and Clinical Pharmacy, Asfendiyarov Kazakh National Medical University, 94 Tole Bi Str., Almaty, 050000, Kazakhstan, E-mail: zhakipbekov.aknmu@bk.ru

Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: This study was approved by the Ethics Commission Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine (Protocol of the meeting of the ethics committee of №1, 04.02.2019). The study was conducted according to the Declaration of Helsinki Principles.

References

1. Mazur, I, Novoshytskyy, V. The relationship between 25-hydroxyvitamin-d level and chronic periodontitis in young women. Visnyk Stomatolohiyi [Bulletin Dentistry] 2016;3:29–33.Search in Google Scholar

2. Holtfreter, B, Albandar, JM, Dietrich, T, Dye, BA, Eaton, KA, Eke, PI, et al. Standards for reporting chronic periodontitis prevalence and severity in epidemiologic studies. J Clin Periodontol 2015;42:407–12, https://doi.org/10.1111/jcpe.12392.Search in Google Scholar

3. Solomon, SM, Iovan, G, Pasarin, L, Sufaru, IG, Martu, I, Luchian, I, et al. Risk predictors in periodontal disease. Roman J Oral Rehabilitation 2017;9:89–96.Search in Google Scholar

4. Penoni, DC, Leão, ATT, Fernandes, TM, Torres, SR. Possíveis ligações entre a osteoporose e a doença periodontal. Rev Bras Reumatol 2017;57:270–3, https://doi.org/10.1016/j.rbr.2015.12.002.Search in Google Scholar

5. Lee, D-J, Wu, L, Shimono, M, Piao, Z, Green, DW, Lee, J-M, et al. Differential mechanism of periodontitis progression in postmenopause. Front Physiol 2018;9:1098, https://doi.org/10.3389/fphys.2018.01098.Search in Google Scholar

6. Singh, N, Grover, C, Grover, S, More, V. Crosstalk between hormones and oral health in the mid-life of women: a comprehensive review. J Int Soc Prev Community Dent 2014;4:5–10, https://doi.org/10.4103/2231-0762.144559.Search in Google Scholar

7. Martelli, ML, Brandi, ML, Martelli, M, Nobili, P, Medico, E, Martelli, F. Periodontal disease and women’s health. Curr Med Res Opin 2017;33:1005–15, https://doi.org/10.1080/03007995.2017.1297928.Search in Google Scholar

8. Prasanna, JS, Sumadhura, C, Karunakar, P. A comparative analysis of pre- and postmenopausal females with periodontitis and its response to a non-invasive clinical approach. J Menopausal Med 2017;23:202–9, https://doi.org/10.6118/jmm.2017.23.3.202.Search in Google Scholar

9. DeBaz, C, Shamia, H, Hahn, J, Mithani, S, Sadeghi, G, Palomo, L. Periodontitis impacts quality of life in postmenopausal women. Climacteric 2015;18:637–42, https://doi.org/10.3109/13697137.2014.996124.Search in Google Scholar

10. Suragimath, G, Mashalkar, V, Zope, S, Varma, S. A cross-sectional study to assess and correlate osteoporosis and periodontitis among postmenopausal women: a dual energy x-ray absorptiometry study. J Mid Life Health 2018;9:2–7, https://doi.org/10.4103/jmh.jmh_39_17.Search in Google Scholar

11. Passos, JS, Vianna, MIP, Gomes-Filho, IS, Cruz, SS, Barreto, ML, Adan, L, et al. Osteoporosis/osteopenia as an independent factor associated with periodontitis in postmenopausal women: a case-control study. Osteoporos Int 2012;24:1275–83, https://doi.org/10.1007/s00198-012-2130-7.Search in Google Scholar

12. Dodd, DZ, Rowe, DJ. The relationship between postmenopausal osteoporosis and periodontal disease. J Dent Hyg 2013;87:336–44.Search in Google Scholar

13. Armitage, GC. Development of a classification system for periodontal diseases and conditions. Northwest Dental 2000;79:31–5, https://doi.org/10.1902/annals.1999.4.1.1.Search in Google Scholar

14. Soules, MR, Sherman, S, Parrott, E, Rebar, R, Santoro, N, Utian, W, et al. Executive summary: stages of reproductive aging workshop (STRAW). Climacteric 2001;4:267–72, https://doi.org/10.1080/cmt.4.4.267.272.Search in Google Scholar

15. Silness, J, Löe, H. Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964;22:121–35, https://doi.org/10.3109/00016356408993968.Search in Google Scholar

16. Russell, AL. A system of classification and scoring for prevalence surveys of periodontal disease. J Dent Res 1956;35:350–9, https://doi.org/10.1177/00220345560350030401.Search in Google Scholar

17. Pereira, FMBG, Rodrigues, VP, de Oliveira, AEF, Brito, LMO, Lopes, FF. Association between periodontal changes and osteoporosis in postmenopausal women. Climacteric 2014;18:311–5, https://doi.org/10.3109/13697137.2014.966239.Search in Google Scholar

18. Gomes-Filho, IS, Oliveira, TJS, Passos, JS, Cerqueira Ede, M, da Cruz, MSS, Barreto, ML, et al. Effect of osteoporosis on periodontal therapy among post-menopausal women. Gerodontology 2012;30:40–8, https://doi.org/10.1111/j.1741-2358.2012.00643.x.Search in Google Scholar

19. Savić Pavičin, I, Dumančić, J, Jukić, T, Badel, T. The relationship between periodontal disease, tooth loss and decreased skeletal bone mineral density in ageing women. Gerodontology 2017;34:441–5, https://doi.org/10.1111/ger.12290.Search in Google Scholar

20. Kolte, RA, Kolte, AP, Potey, AM. Risk assessment of osteoporosis in pre- and postmenopausal periodontally healthy and chronic periodontitis women with digital panoramic radiographs. J Indian Soc Periodontol 2017;21:461–5, https://doi.org/10.4103/jisp.jisp-238-17.Search in Google Scholar

21. Richa, RY, Puranik, MP, Shrivastava, A. Association between osteoporosis and periodontal disease among postmenopausal Indian women. J Investig Clin Dent 2016;8:e12223, https://doi.org/10.1111/jicd.12223.Search in Google Scholar

22. Passos-Soares, JD, Vianna, MIP, Gomes-Filho, IS, Cruz, SS, Barreto, ML, Adan, LF, et al. Association between osteoporosis treatment and severe periodontitis in postmenopausal women. Menopause 2017;24:789–95, https://doi.org/10.1097/gme.0000000000000830.Search in Google Scholar

23. Juluri, R, Prashanth, E, Gopalakrishnan, D, Kathariya, R, Devanoorkar, A, Viswanathan, V, et al. Association of postmenopausal osteoporosis and periodontal disease: a double-blind case-control study. J Int Oral Health 2015;7:119–23.Search in Google Scholar

24. Alves, RC, Félix, SA, Rodriguez-Archilla, A, Oliveira, P, Brito, J, Dos Santos, JM. Relationship between menopause and periodontal disease: a cross-sectional study in a Portuguese population. Int J Clin Exp Med 2015;8:11412–9.Search in Google Scholar

25. Chandak, L, Lohe, V, Bhowate, R, Gandhi, K, Vyas, N. Correlation of periodontitis with mandibular radiomorphometric indices, serum calcium and serum estradiol in postmenopausal women: a case-control study. Indian J Dent Res 2017;28:388–99, https://doi.org/10.4103/ijdr.ijdr_532_16.Search in Google Scholar

26. Hernández-Vigueras, S, Martínez-Garriga, B, Sánchez, MC, Sanz, M, Estrugo-Devesa, A, Vinuesa, T, et al. Oral microbiota, periodontal status, and osteoporosis in postmenopausal females. J Periodontol 2016;87:124–33, https://doi.org/10.1902/jop.2015.150365.Search in Google Scholar

27. Yoshihara, A, Hayashi, Y, Miyazaki, H. Relationships among bone turnover, renal function and periodontal disease in elderly Japanese. J Periodontal Res 2011;46:491–6, https://doi.org/10.1111/j.1600-0765.2011.01365.x.Search in Google Scholar

28. Palomo, L, Chitguppi, R, Buencamino, M, Santos, D, Thacker, H. A need to educate postmenopausal women of their periodontal health. J Indian Soc Periodontol 2013;17:225–7, https://doi.org/10.4103/0972-124x.113082.Search in Google Scholar

Received: 2020-01-29

Accepted: 2020-06-14

Published Online: 2020-08-03

You are currently not able to access this content.

Articles in the same Issue

https://doi.org/10.1515/hmbci-2020-0011

Keywords for this article

alveolar bone loss; bone metabolism; bone remodeling markers; chronic periodontitis; postmenopausal period