Abstract
Ovarian cancer has a high mortality rate. The most common serous type spreads rapidly throughout the peritoneal cavity when 5-year survival is 10%. If diagnosed in earlier stages where the cancer is still confined to the ovary, this survival rate is about 90%. This is the reason to be interested in screening at earlier stages in the average-risk general population. Thus, annual transvaginal ultrasound (TVS) alone or as a multimodal screening test following serum carbohydrate antigen 125 (CA125) has been investigated. Ultrasound lacks sensitivity and specificity; new contrast-enhanced approaches might improve these. When the serum marker is combined with ultrasound and interpreted by a rise in the level rather than by a fixed cut-off, improved sensitivity and specificity and a late but not significant reduction in mortality are observed. Further investigations could highlight the interest of a shorter than annual screening, of a long-term follow-up and new contrast-enhanced ultrasound techniques.
Author statement
Research funding: Authors state no funding involved.
Conflict of interest: Authors state no conflict of interest.
Informed consent: Not applicable.
Ethical approval: Not applicable.
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© 2019 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Special Section: "Update in the management of ovarian cancer"; Guest Editors: René Druckmann and Adolf E. Schindler
- Editorial
- Preface to special issue: update in the management of ovarian cancer
- Original Article
- Ovarian cancer screening in the general population
- Review Articles
- Non-surgical prevention strategies in women with hereditary breast and ovarian cancer syndromes
- Hyperthermic intraperitoneal chemotherapy in ovarian cancer: an update
- Genetic testing in ovarian cancer – clinical impact and current practices
- The place of secondary complete cytoreductive surgery in advanced ovarian cancer
- An update on preoperative assessment of the resectability of advanced ovarian cancer
- Impact of retroperitoneal lymph node dissection in ovarian cancer – time for paradigm shift?
- Minireviews
- Ultrasound screening of ovarian cancer
- How to manage BRCA mutation carriers?
- Regular Issue
- Original Articles
- Progestogen addition with low-dose levonorgestrel intrauterine system in menopausal hormone treatment gives less normal breast tissue proliferation than oral norethisterone acetate or medroxyprogesterone acetate
- The effectiveness of military physical exercise on irisin concentrations and oxidative stress among male healthy volunteers
- Periodontal status and bone metabolism in women in reproductive and postmenopausal periods
- Modulatory effect of tropisetron in the liver of streptozotocin-induced diabetes in rats: biochemical and histological evidence
- Celecoxib versus mefenamic acid in the treatment of primary dysmenorrhea
- The predictive role of amylase and lipase levels on pancreas injury diagnosis in patients with blunt abdominal trauma
- Case Report
- Low hormone levels during an attack of systemic capillary leak syndrome normalizing after treatment
Articles in the same Issue
- Special Section: "Update in the management of ovarian cancer"; Guest Editors: René Druckmann and Adolf E. Schindler
- Editorial
- Preface to special issue: update in the management of ovarian cancer
- Original Article
- Ovarian cancer screening in the general population
- Review Articles
- Non-surgical prevention strategies in women with hereditary breast and ovarian cancer syndromes
- Hyperthermic intraperitoneal chemotherapy in ovarian cancer: an update
- Genetic testing in ovarian cancer – clinical impact and current practices
- The place of secondary complete cytoreductive surgery in advanced ovarian cancer
- An update on preoperative assessment of the resectability of advanced ovarian cancer
- Impact of retroperitoneal lymph node dissection in ovarian cancer – time for paradigm shift?
- Minireviews
- Ultrasound screening of ovarian cancer
- How to manage BRCA mutation carriers?
- Regular Issue
- Original Articles
- Progestogen addition with low-dose levonorgestrel intrauterine system in menopausal hormone treatment gives less normal breast tissue proliferation than oral norethisterone acetate or medroxyprogesterone acetate
- The effectiveness of military physical exercise on irisin concentrations and oxidative stress among male healthy volunteers
- Periodontal status and bone metabolism in women in reproductive and postmenopausal periods
- Modulatory effect of tropisetron in the liver of streptozotocin-induced diabetes in rats: biochemical and histological evidence
- Celecoxib versus mefenamic acid in the treatment of primary dysmenorrhea
- The predictive role of amylase and lipase levels on pancreas injury diagnosis in patients with blunt abdominal trauma
- Case Report
- Low hormone levels during an attack of systemic capillary leak syndrome normalizing after treatment