Lignan glycosides from the stems of Viburnum melanocarpum and their α-glucosidase inhibitory activity
-
Chunchao Zhao
,
Jia Chen
Abstract
Two new lignan glycosides (1, 2) and four known lignan glycosides (3–6) have been isolated from the ethanolic extract of the stems of Viburnum melanocarpum through repeated column chromatography. Their structures including absolute configurations were confirmed by spectroscopic data [one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectra (HRESIMS), optical rotatory dispersion (ORD) and circular dichroism (CD)] and chemical methods. Additionally, the α-glucosidase inhibitory activity of these compounds was tested in vitro. Compound 1 exhibited the strongest inhibitory activity against α-glucosidase with a half-maximal inhibitory concentration (IC50) value of 10.3 μM.
Acknowledgments
We are grateful to the Analytical Detective Center, Yangzhou University, for recording the UV, IR, CD, MS and NMR spectra.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: This work was supported by the National Natural Science Foundation of China (no. 31201563, Funder Id: http://dx.doi.org/10.13039/501100001809).
Employment or leadership: None declared.
Honorarium: None declared.
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Supplementary Material
The online version of this article offers supplementary material (https://doi.org/10.1515/hf-2019-0159).
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Artikel in diesem Heft
- 10.1515/hf-2020-frontmatter1
- Original Articles
- Genotypic variation in the basic density, dynamic modulus of elasticity and tracheid traits of Pinus elliottii in three progeny trials in southern China
- Moisture-dependent orthotropic viscoelastic properties of Chinese fir wood during quenching in the temperature range of 20 to −120°C
- Comparison of whole-tree wood property maps based on near-infrared spectroscopic calibrations utilizing data at different spatial resolutions
- Variation and serial correlation of modulus of elasticity between and within European oak boards (Quercus robur and Q. petraea)
- Natural durability of subfossil oak: wood chemical composition changes through the ages
- Thermo-vacuum treatment of poplar (Populus spp.) plywood
- Dynamic moisture sorption and dimensional stability of furfurylated wood with low lignin content
- From hollow lignin microsphere preparation to simultaneous preparation of urea encapsulation for controlled release using industrial kraft lignin via slow and exhaustive acetone-water evaporation
- Short Note
- Lignan glycosides from the stems of Viburnum melanocarpum and their α-glucosidase inhibitory activity
