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Aligning the education of medical students to healthcare in the UK

  • Guangjie Chen ORCID logo and Peter J. Delves EMAIL logo
Published/Copyright: July 15, 2024

Abstract

How can universities improve their ability to cultivate high-quality and innovative medical talent? The Ministry of Education in China is in the process of implementing the ‘Six Excellent and One Top-Notch’ Plan 2.0 with the aim of substantially revising the teaching of medicine. The United Kingdom (UK) and other countries around the world are also continuously aiming to innovate their medical teaching. With respect to medical education in China, the primary goal is to develop a new medical talent training system that meets future needs, with an emphasis on integration, innovation and interdisciplinary approaches. Here we mainly discuss medical student education systems in the UK with an emphasis on teaching philosophy, objectives, curriculum, and the various types of teaching delivery and assessment that are used in UK medical schools. Through in-depth review of the current situation of medical education in the UK, we hope to provide reference for the reform of the medical education system in China.

Introduction

China’s higher education is entering a stage of popularization, and the development of medical education is entering a new era. Medical education accounts for 8.6 % of students in 13 subject categories. More than 500 colleges or universities in China provide clinical medical education, including 184 undergraduate level universities, constructing the world’s largest medical education system [1]. The Ministry of Education in China is in the process of implementing the ‘Six Excellent and One Top-Notch’ Plan 2.0 with the aim of substantially revising the teaching of engineering, medicine, humanities and agriculture. With respect to medical education, the primary goal is to develop a new medical talent training system that meets future needs, with an emphasis on integration, innovation and interdisciplinary approaches.

Unsurprisingly, given we live in a global world, this is very much the way that medical education in the United Kingdom (UK) and elsewhere is evolving. In the UK, approximately 45 medical schools provide pre-clinical and clinical medical student education. Medical education and healthcare in the UK have their own characteristics. This article will outline the current relationship of the education of medical students to the healthcare systems in the UK. Of comparable importance is the education and training of, for example, nurses, midwives, dentists, pharmacists and numerous allied health professionals but this article will focus on doctors.

Healthcare in the UK

Medical education in the UK needs to be considered against a background in which, like in many other countries throughout the world, healthcare is struggling to keep pace with demand [2]. Patients worry about being able to see a doctor or dentist, and to receive treatment in a timely manner. There is a general feeling that the health service is underfunded and understaffed. Increased funding of healthcare could lead to more beds, shorter waiting times, more clinics, more doctors, more nurses and more ancillary staff. In 2023, both junior doctors (equivalent to interns, residents and fellows in the US) and consultants (senior physicians) in the UK went on strike, an action that in itself raises ethical and moral questions [3] and has the potential to affect patient outcomes [4]. Hospital managers had to put in place strategies to ensure that urgent, emergency and time-critical hospital-based healthcare could continue. The strikes have had a major impact on healthcare delivery and the backlog created has caused considerable concern among many people in the UK.

Healthcare in the UK is delivered by two parallel systems, the National Health Service (NHS) and private healthcare.

The National Health Service Act of 1946 [5] led to the formation of the NHS in 1948. Historically, most of the UK population have been very proud of the NHS with a general feeling that the treatment received is usually of high quality. The NHS Constitution for England states that ‘The NHS belongs to the people’, that it provides ‘a comprehensive service available to all’, and that ‘access to NHS services is based on clinical need, not an individual’s ability to pay’ [6]. NHS treatment is free at the point of care to all who are ‘ordinarily resident’ (living lawfully and on a settled basis) in the UK and is funded by a combination of general taxation plus a ‘National Insurance’ (NI) contribution. NI is an additional tax paid by working people with a contribution from both the employer and the employee. Government income from a portion of general taxation, together with income from NI, is distributed to the NHS.

An indicator of the public’s affection for the NHS is that every week during the COVID-19 pandemic people would lean out of their window, go out onto their balcony or stand outside their front door and clap their hands to show appreciation for the doctors, nurses and all other staff who were having to look after patients affected by SARS-CoV-2 infection.

Whilst access to NHS services is based on clinical need, not an individual’s ability to pay, there are some aspects of NHS healthcare that do require payment; for example, a contribution towards the cost of drug prescriptions, eye care and dental care. However, there are a number of exemptions with reduced or no cost, for example people aged 60 or over, those on a low income, those with certain long-term medical conditions, and so forth. An important organization in the UK healthcare landscape is the National Institute for Health and Care Excellence (NICE) which assesses what the NHS can and cannot afford, for example in terms of new therapeutics.

About 11 % of the UK population have some form of medical insurance [7]. This is often included as part of an employment package in which the employer provides health care insurance. Alternatively, individuals can themselves pay to have private health care insurance. Every working UK citizen over 16 years of age, except those on a low income or of state pension age (currently 66), must pay NI even if they choose to only have private healthcare and not use the NHS at all.

People that do not have private healthcare insurance can, of course, also pay as and when they choose to have private rather than NHS healthcare. The NHS is often unable to keep up with demand, leading to longer waiting times for non-urgent appointments and for operations. For example, if a patient needs a knee replacement due to pain and/or difficulty in walking, this is clearly not an urgent operation compared to somebody that needs the removal of a malignant tumor mass. A knee replacement carried out by the NHS will be free and in theory the operation should be scheduled within 18 weeks of the referral from a primary care physician (general practitioner, GP) to a hospital [8]. However, this target is often not met and the average waiting times for knee replacement in one area of the UK (Swansea) in 2023 was over two years, with nearly half of the patients having to wait longer than this [9]. Furthermore, operations can be cancelled at the last minute. The aim in such cases is to reschedule within a further 28 days [10], but again this is a target which often is not achieved. It is not only the elderly whose quality of life may be greatly impaired. In any age group, extended waiting times can lead to increased physical strain on previously unaffected areas, for example the other knee or the hip, causing further trauma. These waits can therefore be stressful and affect both the patient’s physical and mental well-being. In contrast, if the patient decides to pay to have the operation done privately, they can have a knee replacement within one or two weeks, compared to potentially over two years using the NHS. Therefore, people without private health care insurance are increasingly using a mixture of the NHS for situations that are not urgent and paying for private healthcare if they want something treated quickly. However, private healthcare is expensive and most of the UK population cannot afford this luxury.

Employment and regulation of doctors in the UK

Fully qualified doctors in the UK can work either in the NHS or in private healthcare, or in both [11]. If working in private healthcare, doctors can potentially earn significantly more than if they only work in the NHS. Because the NHS does not collect data on the work that doctors undertake outside of the NHS, hard data is difficult to obtain. It is estimated that approximately 35%–50% of senior doctors do at least some private work. However, most of these spend the majority of their time working within the NHS and less than 10 % working exclusively in private healthcare [12].

Regulation of all doctors, both in the NHS and private sector, is by annual appraisal by their employer. In addition, the General Medical Council (GMC, a government-appointed body) validates doctors and then revalidates them every five years, certifying them to continue to practice [13]. The GMC decides which doctors are qualified to work in the UK and will take action to prevent a doctor from putting the safety of patients, or the public’s confidence in doctors, at risk.

UK medical schools

As of 2024, there are 45 medical schools in the UK. However, the number of medical graduates is insufficient for the needs of the NHS. Currently, there’s a UK government cap at approximately 9,500 students per year. Although this is an increase of 2,000 from 10 years ago, it’s still not sufficient to supply the UK’s need for doctors [14]. The head of every medical school is a member of an organization called the Medical Schools Council [15] which wants to expand the number of medical students in the UK to 14,000 per year. Even then, due to the aging population, more complex treatments, etc., the NHS would still need to recruit doctors from abroad [16]. The number of doctors per population actually varies quite a bit throughout the world. For example, in Sweden, there are 7.0 doctors per thousand people; in Germany, 4.5; in the USA, 3.6; in the UK, 3.1; in China, 2.4; and in India, 0.7 [17]. Although the effectiveness of healthcare is not solely related to such ratios (depending also on factors such as access to healthcare, quality of the healthcare and so on) there is a general consensus that the UK urgently needs more doctors.

So why doesn’t the UK train more doctors? There are a number of obstacles. Firstly, it’s very expensive to train a doctor [14]. Furthermore, qualified doctors are needed to train junior doctors and this in itself presents a potential barrier to expanding the number of medical students. Also, because there’s not enough doctors now, they don’t necessarily have the time to train junior doctors. Therefore, it’s a bit of a vicious circle.

The standard medical degree in the UK is five years, although in some medical schools it is six years. There are also some four-year accelerated programmes (in some medical schools five years) for graduate entry. Unlike in the USA for example, most UK students do not already possess an undergraduate degree when they start medical school. These students will need to obtain the required grades in their high school examinations, pass an entry examination and, for nearly all medical schools, an interview.

Some UK medical schools offer a preliminary one-year course, so that the medical degree takes six years instead of the standard five years, for students that obtained high grades at the end of school exams (A levels or equivalent) but did not take the required science subjects. This is different to the one-year gateway course mentioned in the next paragraph.

There is a major effort in the UK and elsewhere to widen participation by providing opportunities for students that traditionally would not have gone to medical school, for example, due to socioeconomic or educational barriers. The Medical Schools Council has stated that ‘an applicant’s chance of entering a medical degree programme should be dictated by factors such as academic ability, motivation and conscientiousness. Factors like wealth or cultural background should not present any barrier to studying medicine [15]. Not only does widening participation provide opportunities for students but it results in a medical profession that more accurately reflects the diversity of the population it serves. Some medical schools in the UK offer a medical degree with an additional one-year gateway for students that exhibit excellent potential but are from backgrounds where there have been barriers to their learning. There are also access courses available, which are not run by the medical schools, for mature learners that do not possess the qualifications required for standard entry to medicine. Thus, there are now a number of non-traditional routes into UK medical schools.

Four of the world’s top 10 medical schools are in the UK; University of Cambridge, University of Oxford, Imperial College London and University College London (UCL) [18]. Thus, the UK is clearly well-placed to provide high quality medical education. Of the 45 medical schools, five have a compulsory integrated/intercalated BSc (Cambridge, Edinburgh, Imperial, Oxford, and UCL), 30 have an optional, integrated/intercalated BSc and 10 do not offer the option of doing a BSc in addition to the medical degree. Upon graduation, newly qualified doctors undergo two years of foundation training. This is followed by three years of specialty training for junior doctors that are going to become GPs or between five and eight years for other specialties [19]. Junior doctors all work in the NHS initially but can take on private work after completing their specialty training.

Medical education in the UK

Philosophy

Each medical school teaches a little bit differently, and the content varies somewhat from one medical school to another. Thus, some medical schools use problem-based learning whilst others do not, some have a more integrated approach and others less integration of different subject areas, etc. However, when developing the curriculum for a new medical school, or aiming to update or ‘innovate’ the curriculum of an existing medical school, it is worth asking a very fundamental question; ‘What do we want from a doctor when we get ill, or when we need advice on how to prevent ourselves from becoming ill?’ At its most basic level one could propose just three attributes:

  1. A professional and caring attitude

    Doctors should be able to explain, at a level appropriate for an individual patient, the line of enquiry they are proposing and (following diagnosis) the treatment options. They need to be sensitive when breaking bad news, and patient safety must be their first priority. They also need to be constantly updating their knowledge, be aware of their own limitations, and proactively seek the opinion of expert colleagues when necessary.

  2. Be able to ascertain an accurate diagnosis

    Be able to ascertain an accurate diagnosis in the knowledge that patients with the ‘same’ disease may have quite different symptoms and that some patients may present atypically for a particular disease condition. They must be aware of non-obvious and rare conditions that the patient could potentially have.

  3. Develop a patient-specific treatment plan

    Having obtained a diagnosis, they need to develop a patient-specific treatment plan, and be alert to the fact that the treatment may need to be changed (for example, if the patient exhibits significant side effects from the treatment).

Professionalism, accurate diagnosis, and appropriate treatment: if we put ourselves in the place of a patient, and we are all patients sometimes, these are the three things that we all want from our doctor. Therefore, in terms of medical education, the curriculum needs to ensure that graduates fully fulfil these three requirements.

Focusing on the primary objectives

It is essential that junior doctors graduating from medical school have a sufficient level of scientific understanding to enable them to reach an accurate diagnosis and to understand the therapeutic approaches they can use. However, it is arguable that we often teach medical students too much basic science. If this is true, why do we teach immunology, endocrinology, neuroscience, etc., at such a great level of detail? There are potentially a number of reasons. Sometimes it is because there is a national curriculum, but this does not apply in the UK or in China. Sometimes it is simply because the Head of Department asked a colleague to give 12 lectures on adaptive immunity and provided them with a timetable and a list of the lectures. Therefore, it is imperative that the relevant senior staff, teaching committees, etc., can justify the number of teaching hours devoted to particular topics.

The question must arise; ‘are we really teaching the right content?’ Are there things in a lecture that were interesting to tell our students about but that we rarely assess them on? And if it is not worth examining, why did we teach it? Of course, teaching isn’t just about students passing their exams – although from the students’ perspective it often is. From an academic’s perspective, however, it is also about inspiring the future generation of clinician researchers and there will always be some students that fall into that category. But the majority of students probably just want to become excellent doctors rather than also becoming high-flying researchers. Therefore, one could certainly make an argument that we teach basic science in too much detail for the needs of the majority of medical students.

To pick just one example of something that an immunology teacher needs to consider; does a doctor really need to know or understand in any detail the signaling pathways from the T cell receptor in order to make an accurate diagnosis or decide an appropriate treatment plan? Do we care if our doctor knows this stuff? They do need to know, for example, that cyclosporine is a drug used to limit transplant rejection and to treat diseases such as psoriasis, rheumatoid arthritis and nephrotic syndrome and so on. They also need to know that cyclosporine is an immunosuppressive drug, to understand the different components of the immune response, to appreciate at a basic level why immunosuppression can be used to limit transplant rejection and treat autoimmune disease, and why using an immunosuppressive drug will potentially mean that the patient is more likely to get infections. But they probably don’t need to know that cyclosporine is a calcineurin inhibitor, a cytochrome P450 3A4 inhibitor, and a P-glycoprotein inhibitor. Indeed, they probably don’t even need to know that cyclosporine inhibits the synthesis of IL-2 required for the activation and differentiation of T cells.

As already mentioned, when a patient goes to the doctor, they want the doctor to be really good at communicating, tell them what’s wrong with them, and work out how they’re going to be treated. As long as they are able to do this, do we really care if they know that cyclosporine inhibits the synthesis of IL-2? So surely, as educators, we need to ask ourselves why we teach and assess students on this information? If we conclude that our students don’t need to know this level of detail, then a rather obvious question is ‘should medical degrees be shorter?’ Arguably, two years of basic science could probably be adequately covered in one year. Paradoxically, staff are often protective of their number of teaching hours even when in reality they would prefer to be spending more time on research. So, there’s often a tension which probably arises from the way that universities assess their staff. Indeed, academic staff often feel that there is an expectation that they need to excel at research, excel at teaching, and excel at administration. Even when the university does not in fact have this expectation, staff still feel that the pressure is there for them to be good at everything in order to get career progression. This has changed quite a bit in recent years but it is still a perceived issue in many institutions.

If the primary science component of a medical degree is shortened from two years to one year, would medical schools still be able to offer students the possibility of obtaining a BSc degree in addition to their medical degree? This could be easily achieved by allowing students at the end of year one to choose between continuing the core medical degree or, for those who are particularly inspired by the science in their first year, to take an additional two years of study before rejoining the core medical programme.

Styles of teaching

In the UK, every medical school has its own syllabus and regulations for their medical degree. The courses at each medical school have somewhat different content, use different methods of teaching, and different methods of assessment. Thus, UK medical schools have the freedom to teach and assess in any way they wish so long as graduates demonstrably meet the standards and learning outcomes that are set by the GMC [20]. One consequence of this is that it’s important that school students who are thinking of going to medical school appreciate the difference between different medical schools. They need to consider not only the location of the medical school and how ‘prestigious’ it is, but also whether the programme suits their learning style.

Is the traditional style of lecturing at all relevant anymore? At least some students enjoy traditional lectures, perhaps sometimes because they see attending lectures as a quick and easy way to gain the information they need to pass their exams. But it may not be the most effective way of learning. Hence, there have been more student-centered approaches such as problem-based learning [21]. However, it is by no means clear that approaches other than lectures necessarily aid understanding or memory retention [22]. The majority of students admit that they learn material to pass the exams and then forget much of it when they move on to the next subject. However, this perception regarding the loss of basic science knowledge has been questioned [23].

Regarding the structure of the curriculum, the medical degrees at the University of Oxford and at the University of Cambridge are quite traditional in their approach with distinct pre-clinical and then subsequently clinical courses. The students get a BSc during their pre-clinical phase. You could say they’re a bit ‘old fashioned’ but nonetheless they are extremely successful medical schools, ranking amongst the top 10 medical schools in the world and producing amongst the very best doctors internationally. The majority of medical schools in the UK, however, have integrated/systems-based courses with some of these using a predominantly problem-based learning approach.

The science for the ‘New Medical Sciences’ in China emphasizes integration, innovation and interdisciplinary approaches. This is also an objective in UK medical schools. With regard to integration, there are various levels and types of integration: integration of basic science with clinical aspects, interdisciplinary approaches (integration of endocrinology with immunology, for example), and so on. Innovation is an overused word, used everywhere by everybody, but what is really important is that innovation is evidence-based [24]. There’s little point in innovating unless it’s likely to improve on what came before. Evidence is needed to suggest that the changes to be made are likely to prove advantageous in the setting where they will be applied. In addition to evidence-based innovation in teaching and assessment, there is also a need to teach the subject of innovation. Most academics are not experts in innovation, rather they are experts in their own subject area. However, there are individuals in many universities who are experts in innovation and they should be consulted before any proposed changes are undertaken.

Large universities such as Shanghai Jiao Tong University or UCL have expertise distributed throughout the university. Quite often it’s hard to link into that expertise but opening up lines of communication with other specialists is crucial. An interdisciplinary approach can be facilitated by joint teaching with two teachers in the classroom, or online, at the same time. For example, a neuroscientist and a biochemist, a cardiologist and an engineer, or an oncologist and a statistician. This needs to be managed carefully because it can end up as a dialogue between the two teachers who might almost disregard that there are students in the room. However, it can work very well if managed properly. An alternative to ‘teaching’ could simply be a discussion between two experts, talking at a level of expertise that is accessible to students, followed by a Q&A session at the end. If carried out remotely, this can even involve experts from different countries.

Assessment

Ultimately the most important aspect of medical education is to ensure that there is robust, valid and authentic assessment of students [25]. This is key to ensuring that medical graduates will be competent and safe doctors. Individual medical schools in the UK employ a range of different assessment types [26], mapped against the learning outcomes at each stage. Assessments are also mapped to the entire curriculum and appropriately sequenced to match the progression through education and training pathways. The primary assessment requirement of medical schools in the UK is to comply with the GMC standards. Furthermore, the GMC requires that assessments are carried out by someone with appropriate expertise in the area being assessed, and who has been appropriately selected, supported and appraised [20].

Regulating UK medical education

As already discussed, the GMC sets the standards that must be met when teaching, assessing and providing learning opportunities for UK medical students [20]. Graduates ‘must demonstrate professional values and behaviors, professional skills, and professional knowledge’. These encompass ‘professional ethical and legal responsibilities, patient safety and quality improvement, dealing with complexity and uncertainty, safeguarding vulnerable patients, leadership and team working, communication and interpersonal skills, diagnosis and medical management, prescribing medications safely, and using information effectively and safely’. Students also need to be aware of the similarities and differences between the healthcare systems in the four administrative regions of England, Scotland, Wales and Northern Ireland which collectively constitute the UK because although they are all part of the NHS, the way that healthcare is delivered does vary slightly [27]. If doctors have been trained in England and then, for example, go to work in Scotland, they need to be aware of any differences in healthcare management and delivery.

Other components of the GMC standards relate to applying biomedical scientific principles, psychological principles, social science principles, health promotion and illness prevention, and clinical research and scholarship. Newly qualified doctors must be able to apply biomedical scientific principles to their practice and integrate these principles into patient care. The GMC states that this includes principles and knowledge relating to anatomy, biochemistry, cell biology, genetics, genomics, and personalized medicine, immunology, microbiology, molecular biology, nutrition, pathology, pharmacology, and clinical pharmacology, and physiology. Newly qualified doctors must be able to:

  1. Explain human structure, function, physiological processes in health and disease, including in infants, children, pregnancy, childbirth and the elderly

  2. Explain relevant scientific processes underlying common and important disease processes

  3. Justify the selection of appropriate investigations for common clinical conditions and diseases

  4. Select appropriate forms of management for common diseases

  5. Select ways of preventing common diseases

  6. Explain modes of action of common disease, and their risks from first principles

  7. Describe therapeutics, pharmacokinetics, side effects and interactions

  8. Describe pharmacogenomics

  9. Describe antimicrobial stewardship

  10. Analyze clinical phenomena

  11. Conduct appropriate critical appraisal and analysis of clinical data

  12. Explain clinical reasoning in action and how to formulate a differential diagnosis and management plan

Whilst the GMC standards listed above provide clear guidance on what should be taught to medical students, and certainly these are attributes that one would want in one’s own doctor, it does leave open the question as to what level of detail each of these areas needs to be taught? Above all, the duties of a doctor registered with the GMC once they are qualified is to make the care of their patients their first concern, provide a good standard of practice and care, keep their professional knowledge and skills up to date, and work within the limits of their competence. It is really important that we instill in our medical students the fact that they’ll never know everything and that, on occasion, they will need to consult with colleagues. Safety and quality, communication, partnership, teamwork and maintaining trust are all important aspects of working within competence limits.

It is also important to consider how to measure the ‘success’ of a medical school. Whilst various rankings exist which place one medical school above another, it is fundamentally important that every single medical school produces doctors that are safe and effective. How do medical schools ensure that they are actually doing what they intend to be doing? There are of course a variety of ways in which relevant data can be gathered. These include student feedback, student outcomes, internal review and external review. In the UK, there is a GMC annual self-assessment questionnaire which is checked against data and intelligence, and medical school management has to meet every year with the GMC quality assurance team to ensure that, despite their diverse curricula, teaching styles and assessments, all UK medical schools can demonstrate that they comply with the GMC standards and learning outcomes for medical education.

Employer feedback can also be extremely helpful. When healthcare systems are employing doctors from a particular medical school, how do senior doctors and managers feel those doctors compare to other doctors who trained in other medical schools? Are there any gaps in knowledge or in attitudes and professional behaviors that might need addressing when updating the curriculum?

Summarizing and looking ahead

Medical education bears the important mission of cultivating high-quality health talent, and its fundamental task is to address the demand for individuals with professional qualities, practical abilities and innovative spirit. By providing healthcare staff that are aligned to technological achievement and social service, medical schools contribute to comprehensive societal progress and development of the health industry.

Chinese medical education follows the direction of modern medical integration development, emphasizing the integration of clinical treatment and disease prevention, basic and clinical integration, clinical and pharmaceutical integration, and the integration of medicine and humanities in the process of talent cultivation. Chinese medical education has gradually formed its own characteristics, and its international competitiveness has also significantly improved [1].

Medical education in the UK is considered amongst the best in the world. Both domestic and international students are able to gain a comprehensive knowledge of all aspects of medicine. In addition, students’ practical abilities are cultivated by provision of practical medical experience through clinical internships and internship arrangements. The medical curriculum and quality in the UK must comply with GMC standards. There are certain differences between medical education in the UK and China in terms of educational objectives, teaching models, and evaluation methods. This article summarized the characteristics of medical education in the UK, which has certain reference significance for improving the quality of medical education in China and generating high-quality medical talent.

The new era of medical education has arrived. Artificial intelligence (AI) is changing both medical education and the work of doctors [28]. Currently, medical school curricula and assessments are designed by humans but in the future, they may well be designed by AI. Nevertheless, academics and clinicians will need to ensure that AI-developed curricula and assessments are appropriate. We also need to teach our students how to optimally utilize AI, both during their time in medical school and in their future work. One of many current approaches is to ask students to use AI to write an essay on a particular topic and then have the students critique the essay produced by the AI. Could they have produced a better essay themselves, either without using AI at all or by using AI as one of several sources? Clearly, there are ways to capitalize upon the fact that students use AI rather than seeing it as a threat to academic rigor. It is imperative that teachers in medical schools collaborate with colleagues in their own universities, or in other universities, who are computer scientists with expertise in AI. For example, the membership of teaching committees should include someone who is an expert in AI. There is a brave new world out there that medical schools and curriculum committees need to fully embrace.


Corresponding author: Peter J. Delves, Division of Infection and Immunity, Faculty of Medical Sciences, University College London, London, WC1E 6BT, UK, E-mail: 

Funding source: Curriculum Construction Teaching Project of Shanghai Jiao Tong University, School of Medicine

Award Identifier / Grant number: Grant No. YW202301

  1. Research ethics: Not applicable.

  2. Author contributions: Guangjie Chen and Peter J. Delves authored this manuscript. The authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: The authors state no conflict of interest.

  4. Research funding: This research was funded by Curriculum Construction Teaching Project of Shanghai Jiao Tong University, School of Medicine (grant number YW202301).

  5. Data availability: Not applicable.

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Received: 2024-03-18
Accepted: 2024-05-20
Published Online: 2024-07-15

© 2024 the author(s), published by De Gruyter on behalf of the Shanghai Jiao Tong University and the Shanghai Jiao Tong University School of Medicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

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