Sodium alginate nanoparticles as a new transdermal vehicle of glucosamine sulfate for treatment of osteoarthritis
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Asmaa S. El-Houssiny
Asmaa S. El-Houssiny obtained her BSc in Special Biophysics at the Faculty of Science, Cairo University, in 2007. She joined the National Research Center, Egypt, in 2008 and has been working there until now (2017). She earned an MSc in Molecular Biophysics at Cairo University in 2012. In 2017, she received her PhD in Molecular Biophysics at Cairo University, entitled “Preparation and characterization of biopolymeric nanoparticles as transdermal drug carriers for treatment of osteoarthritis on experimental animals”. Her research interests are in the fields of polymers, nanotechnology and drug delivery. She attended several conferences and workshops in Egypt. She had the chance to participate in training at the center of carbon and polymeric material in Poland, 2016. In 2017, she furthermore had the chance to participate in the 9th HOPE Meeting with Nobel Laureates in Tokyo, Japan. She published three international papers and applied for two patents at the Academy of Scientific Research and Technology, Egypt.
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Azza A. Ward
Azza A. Ward obtained her BSc degree from the Physics Department, Faculty of Science, at El Monoufia University, Egypt, in 1990. She joined the National Research Centre team in Egypt in 1991. She earned an MSc degree in Physics at the Faculty of Science at El Monoufia University in 1997. Her PhD degree was obtained in Physics at the Faculty of Science, Cairo University, through the DAAD Channel Program in Germany 1999–2002. She was granted the degree of Professor of Physics in 2015. She is interested in the fields of polymers, liquid crystal, experimental physics, power storage applications and dielectric spectroscopy. She shared in about eight in-house research projects and supervised two MSc and five PhD theses. She published nearly 52 national and international articles, with others running. She had the chance to attend several international conferences in Egypt and Germany and joined many workshops and scientific societies.
Dina M. Mostafa received her BSc degree in Pharmaceutical Sciences at the College of Pharmacy, Cairo University, in 1990. She has worked as a research scientist since 1990 until now (2017) at NRC, Egypt. She was granted the degree of Professor of Pharmaceutics in April 2016. She shared in about 10 in-house research projects and supervised 13 MSc and PhD theses. She cooperated in about eight patents, with one accepted in 2004. She published nearly 31 national and international articles, with others running. She shared in writing a book chapter with colleagues. She joined international conferences and scientific societies and reviewed articles for international journals.
Salwa L. Abd-El-Messieh studied at Ain Shams University where she obtained her BSc in Physics in 1984. In 1989, she received her MSc from Cairo University in Experimental Physics. She was granted a PhD degree from Cairo University in Experimental physics in 1994. Her research work began in 1984 up until now at the National Research Center, Egypt. She was granted the degree of Professor of Physics in April 2004. Her fields of research are experimental physics in general and electrical insulators and dielectric phenomena in particular. She has published nearly 80 national and international articles, with others running. She has engaged in a number of research projects and supervised eight MSc and PhD theses. She had the chance to attend several conferences and fellowships in Egypt, England, Germany, Poland, Washington and Italy.
Kamal N. Abdel-Nour studied at Cairo University where he obtained his BSc in “Physics and Chemistry” in 1962. In 1966, he was granted his MSc in “Absorption and scattering of microwave in media”. His PhD degree was obtained in 1970 from Cairo University and conducted in cooperation with Princeton University, USA. He was granted the degree of Professor of Physics in 1983. He has published 110 papers in national and international journals in the field of electrical properties and applications of microwaves in molecular physics. Under his supervision, several MSc (11) and PhD (9) degrees have been granted. He has engaged in a number of research projects and had the chance to attend several conferences and scholarships in USA, China, Spain, Poland, England, Iraq and Egypt.
Mirhane M. Darwish was granted her BSc in Biophysics at the Faculty of Science, Cairo University, in 2005. She was employed as Demonstrator of Biophysics at the Faculty of Science, Cairo University, in 2006. In 2009, she gained her MSc in Biophysics at Cairo University. She earned her PhD in Biophysics at Cairo University in 2012 entitled “Characterization and Optimization of alginate-chitosan nanoparticles as an insulin carrier”. She has worked as a lecturer of Biophysics at the Faculty of Science, Cairo University, from 2012 till now. She attended several conferences and workshops in Egypt. She published five international papers and supervised three MSc and two PhD theses. Her fields of research lie in biophysics, liposome, nanotechnology and drug delivery.
Wafaa A. Khalil was granted the degree of BSc in Physics at the Faculty of Science, Cairo University, in 1969. In 1974, she gained her MSc at the Faculty of Science, Cairo University. She was granted the PhD degree at Cairo University in 1980. Since 1994, she occupies the position of Professor of Biophysics at the Faculty of Science, Cairo University. She is part of one of the scientific groups that established the Biophysics Department at the Faculty of Science, Cairo University. She has supervised a large number of MSc (32) and PhD (27) theses in physics, biophysics and related fields. Her research interests are in the fields of health physics application of drug carriers and nanoparticles in medicine, nuclear medicine and radiotherapy. She is a member of several national scientific committees in Egypt.
Abstract
Glucosamine sulfate (GS) has been used orally for the treatment of osteoarthritis (OA). However, it may be susceptible to the liver first pass phenomenon, which greatly affects its bioavailability, in addition to its side effects on the gastrointestinal tract. Alginate nanoparticles (Alg NPs) were investigated as a new drug carrier for transdermal delivery of GS to improve its effectiveness and reduce side effects. GS-Alg NPs were characterized by encapsulation efficiency, NP yield, particle size and surface charge properties. The in vitro release studies of GS and the ex vivo permeability through rat skin were determined using a UV-Vis spectrophotometer. GS-Alg NPs are within the nanometer range of size. High negative surface charge values are obtained and indicate the high suspension stability of the prepared formulation. The in vitro release studies showed that GS is released from Alg NPs in a sustained and prolonged manner. The ex vivo permeability of GS through rat skin is enhanced significantly after encapsulation in the negatively charged Alg NPs. We successfully reported a highly stable nanoparticlulate system using Alg NPs that permits the encapsulation of GS for topical administration, overcoming the disadvantages of oral administration.
About the authors
Asmaa S. El-Houssiny obtained her BSc in Special Biophysics at the Faculty of Science, Cairo University, in 2007. She joined the National Research Center, Egypt, in 2008 and has been working there until now (2017). She earned an MSc in Molecular Biophysics at Cairo University in 2012. In 2017, she received her PhD in Molecular Biophysics at Cairo University, entitled “Preparation and characterization of biopolymeric nanoparticles as transdermal drug carriers for treatment of osteoarthritis on experimental animals”. Her research interests are in the fields of polymers, nanotechnology and drug delivery. She attended several conferences and workshops in Egypt. She had the chance to participate in training at the center of carbon and polymeric material in Poland, 2016. In 2017, she furthermore had the chance to participate in the 9th HOPE Meeting with Nobel Laureates in Tokyo, Japan. She published three international papers and applied for two patents at the Academy of Scientific Research and Technology, Egypt.
Azza A. Ward obtained her BSc degree from the Physics Department, Faculty of Science, at El Monoufia University, Egypt, in 1990. She joined the National Research Centre team in Egypt in 1991. She earned an MSc degree in Physics at the Faculty of Science at El Monoufia University in 1997. Her PhD degree was obtained in Physics at the Faculty of Science, Cairo University, through the DAAD Channel Program in Germany 1999–2002. She was granted the degree of Professor of Physics in 2015. She is interested in the fields of polymers, liquid crystal, experimental physics, power storage applications and dielectric spectroscopy. She shared in about eight in-house research projects and supervised two MSc and five PhD theses. She published nearly 52 national and international articles, with others running. She had the chance to attend several international conferences in Egypt and Germany and joined many workshops and scientific societies.
Dina M. Mostafa received her BSc degree in Pharmaceutical Sciences at the College of Pharmacy, Cairo University, in 1990. She has worked as a research scientist since 1990 until now (2017) at NRC, Egypt. She was granted the degree of Professor of Pharmaceutics in April 2016. She shared in about 10 in-house research projects and supervised 13 MSc and PhD theses. She cooperated in about eight patents, with one accepted in 2004. She published nearly 31 national and international articles, with others running. She shared in writing a book chapter with colleagues. She joined international conferences and scientific societies and reviewed articles for international journals.
Salwa L. Abd-El-Messieh studied at Ain Shams University where she obtained her BSc in Physics in 1984. In 1989, she received her MSc from Cairo University in Experimental Physics. She was granted a PhD degree from Cairo University in Experimental physics in 1994. Her research work began in 1984 up until now at the National Research Center, Egypt. She was granted the degree of Professor of Physics in April 2004. Her fields of research are experimental physics in general and electrical insulators and dielectric phenomena in particular. She has published nearly 80 national and international articles, with others running. She has engaged in a number of research projects and supervised eight MSc and PhD theses. She had the chance to attend several conferences and fellowships in Egypt, England, Germany, Poland, Washington and Italy.
Kamal N. Abdel-Nour studied at Cairo University where he obtained his BSc in “Physics and Chemistry” in 1962. In 1966, he was granted his MSc in “Absorption and scattering of microwave in media”. His PhD degree was obtained in 1970 from Cairo University and conducted in cooperation with Princeton University, USA. He was granted the degree of Professor of Physics in 1983. He has published 110 papers in national and international journals in the field of electrical properties and applications of microwaves in molecular physics. Under his supervision, several MSc (11) and PhD (9) degrees have been granted. He has engaged in a number of research projects and had the chance to attend several conferences and scholarships in USA, China, Spain, Poland, England, Iraq and Egypt.
Mirhane M. Darwish was granted her BSc in Biophysics at the Faculty of Science, Cairo University, in 2005. She was employed as Demonstrator of Biophysics at the Faculty of Science, Cairo University, in 2006. In 2009, she gained her MSc in Biophysics at Cairo University. She earned her PhD in Biophysics at Cairo University in 2012 entitled “Characterization and Optimization of alginate-chitosan nanoparticles as an insulin carrier”. She has worked as a lecturer of Biophysics at the Faculty of Science, Cairo University, from 2012 till now. She attended several conferences and workshops in Egypt. She published five international papers and supervised three MSc and two PhD theses. Her fields of research lie in biophysics, liposome, nanotechnology and drug delivery.
Wafaa A. Khalil was granted the degree of BSc in Physics at the Faculty of Science, Cairo University, in 1969. In 1974, she gained her MSc at the Faculty of Science, Cairo University. She was granted the PhD degree at Cairo University in 1980. Since 1994, she occupies the position of Professor of Biophysics at the Faculty of Science, Cairo University. She is part of one of the scientific groups that established the Biophysics Department at the Faculty of Science, Cairo University. She has supervised a large number of MSc (32) and PhD (27) theses in physics, biophysics and related fields. Her research interests are in the fields of health physics application of drug carriers and nanoparticles in medicine, nuclear medicine and radiotherapy. She is a member of several national scientific committees in Egypt.
Conflict of interest statement: Authors state no conflict of interest. All authors have read the journal’s publication ethics and publication malpractice statement available at the journal’s website and hereby confirm that they comply with all its parts applicable to the present scientific work.
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©2017 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- In this issue
- Review
- Endoscopic imaging using surface-enhanced Raman scattering
- Original Articles
- Sodium alginate nanoparticles as a new transdermal vehicle of glucosamine sulfate for treatment of osteoarthritis
- Tailor-made mucoadhesive lipid nanogel improves oromucosal antimycotic activity of encapsulated miconazole nitrate
- Disulfiram and disulfiram-loaded poly-[lactide-co-glycolic acid] nanoparticles modulate metastatic markers and proteasomal activity in hepatocarcinoma Hep3b cell line
Artikel in diesem Heft
- Frontmatter
- In this issue
- Review
- Endoscopic imaging using surface-enhanced Raman scattering
- Original Articles
- Sodium alginate nanoparticles as a new transdermal vehicle of glucosamine sulfate for treatment of osteoarthritis
- Tailor-made mucoadhesive lipid nanogel improves oromucosal antimycotic activity of encapsulated miconazole nitrate
- Disulfiram and disulfiram-loaded poly-[lactide-co-glycolic acid] nanoparticles modulate metastatic markers and proteasomal activity in hepatocarcinoma Hep3b cell line
