Startseite Medizin Endoscopic imaging using surface-enhanced Raman scattering
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Endoscopic imaging using surface-enhanced Raman scattering

  • Yong-il Kim

    Yong-il Kim is Assistant Professor of Nuclear Medicine at CHA Bundang Medical Center, CHA University. He obtained his MD degree (2008) and PhD degree (2016) from Seoul National University. He fulfilled a 4-years’ residency program at the Department of Nuclear Medicine, Seoul National University Hospital and obtained Nuclear Medicine Board Certification (2013). He won Young Investigator Awards at the 2015 Asia Oceania Congress of Nuclear Medicine and Biology, the 2015 Japanese Society of Nuclear Medicine meeting, and the 2016 Society of Nuclear Medicine and Molecular Imaging meeting, and in 2017 he received the Alavi-Mandell Publication Award. His research interests focus on the nuclear oncology and theranostics of cancer.

         , Sinyoung Jeong

    Sinyoung Jeong is a research Fellow at Massachusetts General Hospital and Harvard Medical School. He received his PhD in Physical Chemistry from Seoul National University in 2016, under the supervision of Prof. Dae Hong Jeong. He received his BS (2010) and MS (2012) from the Department of Chemistry Education at Seoul National University. He has mainly studied Raman spectroscopy for bio-application. His PhD research was focused on developing surface enhanced Raman scattering-based in vivo and in vitro multi-modal bio-imaging system for multiplexed molecular diagnosis using endoscopy and microscopy, in conjugation with multifunctional optical nanomaterials having specific targeting moiety. Since he has joined the MGH/HMS, he has extended his research into plasmonic nanoparticle-based immunoassays and advanced imaging including coherent anti-stokes Raman scattering, stimulated Raman scattering, two-photon fluorescence and transient absorption imaging.

         , Bong-Hyun Jun

    Bong-Hyun Jun is currently an Associate Professor at Konkuk University, Republic of Korea. He received his PhD degree at the School of Chemical and Biological Engineering, Seoul National University in 2009. He worked at the Seoul National University (2009–2012) and at the University of California, Berkeley (2011–2012). He joined the Konkuk University in 2013, and is working on the design and fabrication of functional materials, as well as their applications for biosensors and bio-imaging. He has served as a member of the board of directors of the Korean Society of Industrial and Engineering Chemistry (2015–current), as well as a member of the board of directors of the Korean Peptide and Protein Society (2013 to date).

         , Yun-Sang Lee

    Yun-Sang Lee is the Brain Korea 21 plus (BK21 plus) Associate Professor in the Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology at Seoul National University. He received his BS and MS from the Department of Chemistry, College of Sciences at Kyunghee University, Korea in 1996 and 1998, and his PhD from the Department of Pharmaceutical Manufacturing Chemistry, College of Pharmacy at Seoul National University, Korea in 2006. He is interested in the field of development and implementation of new methods for radiolabeling chemistry and development of new diagnostic or therapeutic radiopharmaceuticals, and also, the development of new methods for the surface modification or radiolabeling of nano-materials, especially radionanomedicine, and their uses for diagnosis/therapy or theranostics.

         , Yoon-Sik Lee

    Yoon-Sik Lee is a Professor at the School of Chemical and Biological Engineering (1993–2017) at Seoul National University. He obtained his PhD degree (1982) at the Department of Chemistry, Rutgers University. He has served as the President of the Korean Society of Industrial and Engineering Chemistry (2011) and the President of the Korean Peptide and Protein Society (2010–2011). Professor Lee’s work has been focused on bioorganic chemistry, especially in developing solid-phase peptide chemistry. He has developed nanoparticle sensors, especially SERS nano tags and probes for peptide library synthesis and multiplex detection of biomarkers

         , Dae Hong Jeong

    Dae Hong Jeong received his PhD at Seoul National University in 1999, and then worked as a postdoctoral researcher at the Korea Research Institute of Standards and Science, Yonsei University, and at the University of California in Santa Barbara until 2003. From 2003 to date he has been working as a Professor in the Department of Chemistry Education at Seoul National University. His research expertise is Raman spectroscopy including resonance Raman spectroscopy, time-resolved Raman spectroscopy, and surface-enhanced Raman spectroscopy, and during the last decade his research interest has been focused on SERS-based bio-molecular detections, especially multiplexed imaging and immunoassay.

     EMAIL logo     und Dong Soo Lee

    Dong Soo Lee is Professor of Nuclear Medicine at the Seoul National University College of Medicine and Professor of Molecular Medicine and Biopharmaceutical Sciences. He majored in Nuclear Medicine (Neurology and Cardiology), Molecular Imaging and Radionanomedicine. He has served as President of the Korean Society for Nanomedicine and President of the Korean Society of Nuclear Medicine. Currently, he is the Editor-in-Chief of nuclear medicine and molecular imaging, Vice-president of the International Society for Nanomedicine, Editorial Board member of journal of nuclear medicine, european journal of nuclear medicine and molecular imaging. He is also serving as President-elect of the World Federation of Nuclear Medicine and Biology (WFNMB).

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Veröffentlicht/Copyright: 11. September 2017
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European Journal of Nanomedicine
Aus der Zeitschrift European Journal of Nanomedicine Band 9 Heft 3-4

Abstract

In this review, we assessed endoscopic imaging using surface-enhanced Raman scattering (SERS). As white-light endoscopy, the current standard for gastrointestinal endoscopy, is limited to morphology, Raman endoscopy using surface-enhanced Raman scattering nanoparticles (SERS endoscopy) was introduced as one of the novel functional modalities. SERS endoscopy has multiplex capability and high sensitivity with low autofluorescence and photobleaching. As a result, multiple molecular characteristics of the lesion can be accurately evaluated in real time while performing endoscopy using SERS probes and appropriate instrumentation. Especially, recently developed dual modality of fluorescence and SERS endoscopy offers easy localization with identification of multiple target molecules. For clinical use of SERS endoscopy in the future, problems of limited field of view and cytotoxicity should be addressed by fusion imaging, topical administration, and non-toxic coating of nanoparticles. We expect SERS endoscopic imaging would be an essential endoscopic technique for diagnosis of cancerous lesions, assessment of resection margins and evaluation of therapeutic responses.

Keywords: endoscopy; nanoparticles; Raman spectroscopy; surface-enhanced Raman scattering

About the authors

Yong-il Kim

Yong-il Kim is Assistant Professor of Nuclear Medicine at CHA Bundang Medical Center, CHA University. He obtained his MD degree (2008) and PhD degree (2016) from Seoul National University. He fulfilled a 4-years’ residency program at the Department of Nuclear Medicine, Seoul National University Hospital and obtained Nuclear Medicine Board Certification (2013). He won Young Investigator Awards at the 2015 Asia Oceania Congress of Nuclear Medicine and Biology, the 2015 Japanese Society of Nuclear Medicine meeting, and the 2016 Society of Nuclear Medicine and Molecular Imaging meeting, and in 2017 he received the Alavi-Mandell Publication Award. His research interests focus on the nuclear oncology and theranostics of cancer.

Sinyoung Jeong

Sinyoung Jeong is a research Fellow at Massachusetts General Hospital and Harvard Medical School. He received his PhD in Physical Chemistry from Seoul National University in 2016, under the supervision of Prof. Dae Hong Jeong. He received his BS (2010) and MS (2012) from the Department of Chemistry Education at Seoul National University. He has mainly studied Raman spectroscopy for bio-application. His PhD research was focused on developing surface enhanced Raman scattering-based in vivo and in vitro multi-modal bio-imaging system for multiplexed molecular diagnosis using endoscopy and microscopy, in conjugation with multifunctional optical nanomaterials having specific targeting moiety. Since he has joined the MGH/HMS, he has extended his research into plasmonic nanoparticle-based immunoassays and advanced imaging including coherent anti-stokes Raman scattering, stimulated Raman scattering, two-photon fluorescence and transient absorption imaging.

Bong-Hyun Jun

Bong-Hyun Jun is currently an Associate Professor at Konkuk University, Republic of Korea. He received his PhD degree at the School of Chemical and Biological Engineering, Seoul National University in 2009. He worked at the Seoul National University (2009–2012) and at the University of California, Berkeley (2011–2012). He joined the Konkuk University in 2013, and is working on the design and fabrication of functional materials, as well as their applications for biosensors and bio-imaging. He has served as a member of the board of directors of the Korean Society of Industrial and Engineering Chemistry (2015–current), as well as a member of the board of directors of the Korean Peptide and Protein Society (2013 to date).

Yun-Sang Lee

Yun-Sang Lee is the Brain Korea 21 plus (BK21 plus) Associate Professor in the Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology at Seoul National University. He received his BS and MS from the Department of Chemistry, College of Sciences at Kyunghee University, Korea in 1996 and 1998, and his PhD from the Department of Pharmaceutical Manufacturing Chemistry, College of Pharmacy at Seoul National University, Korea in 2006. He is interested in the field of development and implementation of new methods for radiolabeling chemistry and development of new diagnostic or therapeutic radiopharmaceuticals, and also, the development of new methods for the surface modification or radiolabeling of nano-materials, especially radionanomedicine, and their uses for diagnosis/therapy or theranostics.

Yoon-Sik Lee

Yoon-Sik Lee is a Professor at the School of Chemical and Biological Engineering (1993–2017) at Seoul National University. He obtained his PhD degree (1982) at the Department of Chemistry, Rutgers University. He has served as the President of the Korean Society of Industrial and Engineering Chemistry (2011) and the President of the Korean Peptide and Protein Society (2010–2011). Professor Lee’s work has been focused on bioorganic chemistry, especially in developing solid-phase peptide chemistry. He has developed nanoparticle sensors, especially SERS nano tags and probes for peptide library synthesis and multiplex detection of biomarkers

Dae Hong Jeong

Dae Hong Jeong received his PhD at Seoul National University in 1999, and then worked as a postdoctoral researcher at the Korea Research Institute of Standards and Science, Yonsei University, and at the University of California in Santa Barbara until 2003. From 2003 to date he has been working as a Professor in the Department of Chemistry Education at Seoul National University. His research expertise is Raman spectroscopy including resonance Raman spectroscopy, time-resolved Raman spectroscopy, and surface-enhanced Raman spectroscopy, and during the last decade his research interest has been focused on SERS-based bio-molecular detections, especially multiplexed imaging and immunoassay.

Dong Soo Lee

Dong Soo Lee is Professor of Nuclear Medicine at the Seoul National University College of Medicine and Professor of Molecular Medicine and Biopharmaceutical Sciences. He majored in Nuclear Medicine (Neurology and Cardiology), Molecular Imaging and Radionanomedicine. He has served as President of the Korean Society for Nanomedicine and President of the Korean Society of Nuclear Medicine. Currently, he is the Editor-in-Chief of nuclear medicine and molecular imaging, Vice-president of the International Society for Nanomedicine, Editorial Board member of journal of nuclear medicine, european journal of nuclear medicine and molecular imaging. He is also serving as President-elect of the World Federation of Nuclear Medicine and Biology (WFNMB).

  1. Conflict of interest statement: Authors state no conflict of interest. All authors have read the journal’s publication ethics and publication malpractice statement available at the journal’s website and hereby confirm that they comply with all its parts applicable to the present scientific work.

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Received: 2016-12-30
Accepted: 2017-7-26
Published Online: 2017-9-11
Published in Print: 2017-10-26

©2017 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. In this issue
  3. Review
  4. Endoscopic imaging using surface-enhanced Raman scattering
  5. Original Articles
  6. Sodium alginate nanoparticles as a new transdermal vehicle of glucosamine sulfate for treatment of osteoarthritis
  7. Tailor-made mucoadhesive lipid nanogel improves oromucosal antimycotic activity of encapsulated miconazole nitrate
  8. Disulfiram and disulfiram-loaded poly-[lactide-co-glycolic acid] nanoparticles modulate metastatic markers and proteasomal activity in hepatocarcinoma Hep3b cell line
https://doi.org/10.1515/ejnm-2017-0005
Schlagwörter für diesen Artikel
endoscopy; nanoparticles; Raman spectroscopy; surface-enhanced Raman scattering

Artikel in diesem Heft

  1. Frontmatter
  2. In this issue
  3. Review
  4. Endoscopic imaging using surface-enhanced Raman scattering
  5. Original Articles
  6. Sodium alginate nanoparticles as a new transdermal vehicle of glucosamine sulfate for treatment of osteoarthritis
  7. Tailor-made mucoadhesive lipid nanogel improves oromucosal antimycotic activity of encapsulated miconazole nitrate
  8. Disulfiram and disulfiram-loaded poly-[lactide-co-glycolic acid] nanoparticles modulate metastatic markers and proteasomal activity in hepatocarcinoma Hep3b cell line
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